Role of MMP-14 in connective tissue homeostasis and tumour invasion Based on the results of the previous funding period we now want to understand...   Read More

Role of collagen-binding integrin receptors for cellular communication and homeostasis in the skin This project aims at establishing whether and by which mechanisms integrin-mediated...   Read More

Regulation of epidermal stratification and homeostasis through contractility and density sensing How the complex but stereotyped tissue structure of the mammalian epidermis is formed,...   Read More

Mammalian polarity proteins in skin homeostasis and disease How cell morphology is coordinated in the context of an entire organ is an intriguing question...   Read More

Regulation of epidermal morphogenesis and barrier function by intercellular junctions We have demonstrated that classical cadherins through regulation of intercellular junctions, the cytoskeleton and...   Read More

Epithelial TNFR1 signalling in skin homeostasis and inflammation TNF is a critical pathogenic factor in psoriasis and other chronic inflammatory diseases, but the mechanisms...   Read More

Hedgehog-Gli signalling in skin homeostasis and tumour formation Indian Hedgehog (Ihh) controls proliferation and differentiation of keratinocytes and prevents tumour progression and metastasis. Mechanistically,...   Read More