Catecholamine Metabolism Induces Mitochondrial DNA Deletions and Leads to Severe Adrenal Degeneration during Aging

February 19, 2016A14 WIESNER

Neuhaus JF, Baris OR, Kittelmann A, Becker K, Rothschild MA, Wiesner RJ Neuroendocrinology 2017;104(1):72-84 PMID: 26895241 Abstract BACKGROUND: Aging is a multifactorial process characterized... Read More

Structural characterization of twisted gastrulation provides insights into opposing functions on the BMP signalling pathway

February 9, 2016B12 SENGLE

Troilo H, Barrett AL, Zuk AV, Lockhart-Cairns MP, Wohl AP, Bayley CP, Dajani R, Tunnicliffe RB, Green L, Jowitt TA, Sengle G, Baldock C... Read More

The fibronectin/α3β1 integrin axis serves as molecular basis for keratinocyte invasion induced by βHPV

January 28, 2016B4 ZIGRINO MAUCH

Heuser S, Hufbauer M, Steiger J, Marshall J, Sterner-Kock A, Mauch C, Zigrino P, Akgül B Oncogene 2016 Jan; PMID: 26804167 Abstract Organ-transplant-recipients exhibit... Read More

Systemic DNA damage responses in aging and diseases

January 17, 2016A7 SCHUMACHER

Ribezzo F, Shiloh Y, Schumacher B Semin. Cancer Biol. 2016 Jan; PMID: 26773346 Abstract The genome is constantly attacked by a variety of genotoxic... Read More

Characterization of Microfibrillar-associated Protein 4 (MFAP4) as a Tropoelastin- and Fibrillin-binding Protein Involved in Elastic Fiber Formation

January 16, 2016B12 SENGLE

Pilecki B, Holm AT, Schlosser A, Moeller JB, Wohl AP, Zuk AV, Heumüller SE, Wallis R, Moestrup SK, Sengle G, Holmskov U, Sorensen GL... Read More

Foxd3 Promotes Exit from Naive Pluripotency through Enhancer Decommissioning and Inhibits Germline Specification

January 11, 2016A13 RADA-IGLESIAS

Respuela P, Nikolić M, Tan M, Frommolt P, Zhao Y, Wysocka J, Rada-Iglesias A Cell Stem Cell 2016 Jan;18(1):118-33 PMID: 26748758 Abstract Following implantation,... Read More

The actin-binding protein EPS8 binds VE-cadherin and modulates YAP localization and signaling

December 23, 2015A1 NIESSEN

Giampietro C, Disanza A, Bravi L, Barrios-Rodiles M, Corada M, Frittoli E, Savorani C, Lampugnani MG, Boggetti B, Niessen C, Wrana JL, Scita G,... Read More

PhD/Postdoc-Retreat 2015 at Kürten with Prof. Gian-Paolo Dotto

December 11, 2015Annual Retreat Good To Know

The 7th Graduate Retreat of the SFB 829 „Molecular Mechanisms Regulating Skin Homeostasis“ took place in December 2015 in Kürten-Hungenbach. We are very pleased that... Read More

Longevity through DNA damage tolerance

December 7, 2015A7 SCHUMACHERCastells-Roca L, Mueller MM, Schumacher B; Cell Cycle. 2015;14(4):467-8. doi: 10.1080/15384101.2015.1006543.

Pubmed

Myeloid Cell-Restricted Insulin/IGF-1 Receptor Deficiency Protects against Skin Inflammation

December 7, 2015A5 BRÜNING/NIESSEN B7 EMINGKnuever J, Willenborg S, Ding X, Akyüz MD, Partridge L, Niessen CM, Brüning JC, Eming SA; J Immunol. 2015 Dec 1;195(11):5296-308. doi: 10.4049/jimmunol.1501237. Epub 2015 Oct 30.

Abstract Myeloid cells are key regulators of tissue homeostasis and disease. Alterations in cell-autonomous insulin/IGF-1 signaling in myeloid cells have recently been implicated in... Read More

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