Ceramide synthase 4 regulates stem cell homeostasis and hair follicle cycling

May 12, 2015A1 NIESSEN A5 BRÜNING/NIESSEN

Peters F, Vorhagen S, Brodesser S, Jakobshagen K, Brüning JC, Niessen CM, Krönke M J. Invest. Dermatol. 2015 Jun;135(6):1501-9 PMID: 25705848 Abstract Ceramides are... Read More

Reduced granulation tissue and wound strength in the absence of α11β1 integrin

May 11, 2015B3 ECKES KRIEGSchulz JN, Zeltz C, Sørensen IW, Barczyk M, Carracedo S, Hallinger R, Niehoff A, Eckes B, Gullberg D; J Invest Dermatol. 2015 May;135(5):1435-44. doi: 10.1038/jid.2015.24. Epub 2015 Jan 29.

Abstract Previous wound healing studies have failed to define a role for either α1β1 or α2β1 integrin in fibroblast-mediated wound contraction, suggesting the involvement... Read More

Mosaic Deficiency in Mitochondrial Oxidative Metabolism Promotes Cardiac Arrhythmia during Aging

May 9, 2015A14 WIESNER

Baris OR, Ederer S, Neuhaus JF, von Kleist-Retzow JC, Wunderlich CM, Pal M, Wunderlich FT, Peeva V, Zsurka G, Kunz WS, Hickethier T, Bunck... Read More

Mic10 Oligomerization Pinches off Mitochondrial Cristae

May 5, 2015publicationsMilenkovic D, Larsson NG; Cell Metab. 2015 May 5;21(5):660-1. doi: 10.1016/j.cmet.2015.04.020.

Abstract The mitochondrial contact site and cristae organizing system (MICOS) complex is essential for normal mitochondria biogenesis and morphology. In this issue, Bohnert et al.... Read More

Vitamin D controls apoptosis and proliferation of cutaneous T-cell lymphoma cells

May 2, 2015B13 FABRIMrotzek C, Felcht M, Sommer A, Schrader A, Klemke CD, Herling M, Schlaak M, Fabri M; Exp Dermatol. 2015 May 2. doi: 10.1111/exd.12746. [Epub ahead of print]

Modeling autosomal recessive cutis laxa type 1C in mice reveals distinct functions for Ltbp-4 isoforms

April 27, 2015B12 SENGLEBultmann-Mellin I, Conradi A, Maul AC, Dinger K, Wempe F, Wohl AP, Imhof T, Wunderlich FT, Bunck AC, Nakamura T, Koli K, Bloch W, Ghanem A, Heinz A, von Melchner H, Sengle G, Sterner-Kock A; Dis Model Mech. 2015 Apr;8(4):403-15. doi: 10.1242/dmm.018960. Epub 2015 Feb 20.

Abstract Recent studies have revealed an important role for LTBP-4 in elastogenesis. Its mutational inactivation in humans causes autosomal recessive cutis laxa type 1C... Read More

DNA repair mechanisms in cancer development and therapy

April 23, 2015A7 SCHUMACHERTorgovnick A, Schumacher B; Front Genet. 2015 Apr 23;6:157. doi: 10.3389/fgene.2015.00157. eCollection 2015.

Abstract: DNA damage has been long recognized as causal factor for cancer development. When erroneous DNA repair leads to mutations or chromosomal aberrations affecting... Read More

Vitamin D-dependent induction of cathelicidin in human macrophages results in cytotoxicity against high-grade B cell lymphoma

April 8, 2015B13 FABRIBruns H, Büttner M, Fabri M, Mougiakakos D, Bittenbring JT, Hoffmann MH, Beier F, Pasemann S, Jitschin R, Hofmann AD, Neumann F, Daniel C, Maurberger A, Kempkes B, Amann K, Mackensen A, Gerbitz A; Sci Transl Med. 2015 Apr 8;7(282):282ra47. doi: 10.1126/scitranslmed.aaa3230.

Abstract Infiltration by macrophages represents a characteristic morphological hallmark in high-grade lymphatic malignancies such as Burkitt’s lymphoma (BL). Although macrophages can, in principle, target... Read More

Wormpath: searching for molecular interaction networks in Caenorhabditis elegans

April 2, 2015A7 SCHUMACHERFrommolt P, Schumacher B; Source Code Biol Med. 2015 Apr 2;10:5. doi: 10.1186/s13029-015-0034-6. eCollection 2015.

Abstract Background: High-throughput transcriptional profiling using Next-Generation Sequencing (RNA-Seq) or microarray technology have become standard tools in molecular biology. Successful investigations of gene regulatory... Read More

NK cells link obesity-induced adipose stress to inflammation and insulin resistance

April 1, 2015A5 BRÜNING/NIESSENWensveen FM, Jelen?i? V, Valenti? S, Šestan M, Wensveen TT, Theurich S, Glasner A, Mendrila D, Štimac D, Wunderlich FT, Brüning JC, Mandelboim O, Poli? B; Nat Immunol. 2015 Apr;16(4):376-85. doi: 10.1038/ni.3120. Epub 2015 Mar 2.

Abstract An important cause of obesity-induced insulin resistance is chronic systemic inflammation originating in visceral adipose tissue (VAT). VAT inflammation is associated with the... Read More

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