Impact of the Prolymphangiogenic Crosstalk in the Tumor Microenvironment on Lymphatic Cancer Metastasis

September 1, 2014A10 IDENSchlereth S, Refaian N, Iden S, Cursiefen C, Heindl; BioMed Research International. 2014:639058. Epub 2014 Sep 1

Abstract Lymphangiogenesis is a very early step in lymphatic metastasis. It is regulated and promoted not only by the tumor cells themselves, but also... Read More

Col6a1 null mice as a model to study skin phenotypes in patients with collagen VI related myopathies: expression of classical and novel collagen VI variants during wound healing

August 26, 2014B2 WAGENER/ PAULSSON B7 EMINGLettmann S, Bloch W, Maaß T, Niehoff A, Schulz JN, Eckes B, Eming SA, Bonaldo P, Paulsson M, Wagener R; PLoS One. 2014 Aug 26;9(8):e105686. doi: 10.1371/journal.pone.0105686. eCollection 2014.

Abstract Patients suffering from collagen VI related myopathies caused by mutations in COL6A1, COL6A2 and COL6A3 often also display skin abnormalities, like formation of... Read More

Molecular and cellular basis of scleroderma

August 14, 2014B12 SENGLE B3 ECKES KRIEG

Eckes B, Moinzadeh P, Sengle G, Hunzelmann N, Krieg T J. Mol. Med. 2014 Sep;92(9):913-24 PMID: 25030650 Abstract Systemic sclerosis (scleroderma) is a chronic... Read More

Making proteins in the powerhouse

July 31, 2014publicationsHällberg BM, Larsson NG; Cell Metab. 2014 Aug 5;20(2):226-40. doi: 10.1016/j.cmet.2014.07.001. Epub 2014 Jul 31.

Abstract Understanding regulation of mitochondrial DNA (mtDNA) expression is of considerable interest given that mitochondrial dysfunction is important in human pathology and aging. Similar... Read More

Genetic ablation of mast cells redefines the role of mast cells in skin wound healing and bleomycin-induced fibrosis

July 27, 2014B7 EMINGWillenborg S, Eckes B, Brinckmann J, Krieg T, Waisman A, Hartmann K, Roers A, Eming SA; J Invest Dermatol. 2014 Jul;134(7):2005-15. doi: 10.1038/jid.2014.12. Epub 2014 Jan 9.

Abstract Conclusive evidence for the impact of mast cells (MCs) in skin repair is still lacking. Studies in mice examining the role of MC... Read More

Role of integrin signalling through integrin-linked kinase in skin physiology and pathology

July 21, 2014A11 WICKSTRÖM B3 ECKES KRIEG

Eckes B, Krieg T, Wickström SA Exp. Dermatol. 2014 Jul;23(7):453-6 PMID: 24773528 Abstract Cell-matrix adhesions provide structural stability to the tissue and regulate intracellular... Read More

Epidermal p65/NF-κB signalling is essential for skin carcinogenesis

July 4, 2014A4 PASPARAKIS

Kim C, Pasparakis M EMBO Mol Med 2014 Jul;6(7):970-83 PMID: 24952939 Abstract The nuclear factor kappa B (NF-κB) signalling pathway exhibits both tumour-promoting and... Read More

Understanding nucleotide excision repair and its roles in cancer and ageing

June 23, 2014B15 HOEIJMAKERS

Marteijn JA, Lans H, Vermeulen W, Hoeijmakers JH Nat. Rev. Mol. Cell Biol. 2014 Jul;15(7):465-81 PMID: 24954209 Abstract Nucleotide excision repair (NER) eliminates various... Read More

Epidermal RelA Specifically Restricts Contact Allergen-Induced Inflammation and Apoptosis in Skin (2014)

June 17, 2014publicationsKumari S, Herzberg B, Pofahl R, Krieg T, Haase I; J Invest Dermatol. 2014 Apr 16. doi: 10.1038/jid.2014.193. [Epub ahead of print]

Abstract Strong inhibition of NF-κB signaling in the epidermis results in spontaneous skin inflammation in mice and men. As there is evidence for... Read More

Enhanced deposition of cartilage oligomeric matrix protein is a common feature in fibrotic skin pathologies

June 2, 2014publications Agarwal P, Schulz JN, Blumbach K, Andreasson K, Heinegård D, Paulsson M, Mauch C, Eming SA, Eckes B, Krieg T; Matrix Biol. 2013 Aug 8;32(6):325-31. doi: 10.1016/j.matbio.2013.02.010. Epub 2013 Mar 15.

Abstract Skin fibrosis is characterized by activated fibroblasts and an altered architecture of the extracellular matrix. Excessive deposition of extracellular matrix proteins and... Read More

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