Tropism-modified AAV vectors overcome barriers to successful cutaneous therapy

January 28, 2014A1 NIESSENSallach J, Di Pasquale G, Larcher F, Niehoff N, Rübsam M, Huber A, Chiorini J, Almarza D, Eming SA, Ulus H, Nishimura S, Hacker UT, Hallek M, Niessen CM, Büning H; Mol Ther. 2014 May;22(5):929-39. doi: 10.1038/mt.2014.14. Epub 2014 Jan 28.

Abstract Autologous human keratinocytes (HK) forming sheet grafts are approved as skin substitutes. Genetic engineering of HK represents a promising technique to improve engraftment... Read More

Systemic DNA damage responses: organismal adaptations to genome instability

January 15, 2014A7 SCHUMACHERErmolaeva MA, Schumacher B; Trends Genet. 2014 Mar;30(3):95-102. doi: 10.1016/j.tig.2013.12.001. Epub 2014 Jan 15.

Abstract DNA damage checkpoints are important tumor-suppressor mechanisms that halt cell cycle progression to allow time for DNA repair, or induce senescence and apoptosis... Read More

Loss of Caenorhabditis elegans BRCA1 promotes genome stability during replication in smc-5 mutants

January 14, 2014A7 SCHUMACHERWolters S, Ermolaeva MA, Bickel JS, Fingerhut JM, Khanikar J, Chan RC, Schumacher B; Genetics. 2014 Apr;196(4):985-99. doi: 10.1534/genetics.113.158295. Epub 2014 Jan 14.

Abstract DNA damage by ultraviolet (UV) light poses a risk for mutagenesis and a potential hindrance for cell cycle progression. Cells cope with UV-induced... Read More

p53 and TAp63 promote keratinocyte proliferation and differentiation in breeding tubercles of the zebrafish

January 9, 2014A9 HAMMERSCHMIDT Fischer B, Metzger M, Richardson R, Knyphausen P, Ramezani T, Franzen R, Schmelzer E, Bloch W, Carney TJ, Hammerschmidt M; PLoS Genet. 2014 Jan;10(1):e1004048. doi: 10.1371/journal.pgen.1004048. Epub 2014 Jan 9.

Abstract p63 is a multi-isoform member of the p53 family of transcription factors. There is compelling genetic evidence that ΔNp63 isoforms are needed for... Read More

Loss of LRPPRC causes ATP synthase deficiency

January 6, 2014publications Mourier A, Ruzzenente B, Brandt T, Kühlbrandt W, Larsson NG; Hum Mol Genet. 2014 May 15;23(10):2580-92. doi: 10.1093/hmg/ddt652. Epub 2014 Jan 6.

Abstract Defects of the oxidative phosphorylation system, in particular of cytochrome-c oxidase (COX, respiratory chain complex IV), are common causes of Leigh syndrome (LS),... Read More

Reduced inflammatory threshold indicates skin barrier defect in transglutaminase 3 knockout mice

January 2, 2014B2 WAGENER/ PAULSSON Bognar P, Nemeth I, Mayer B, Haluszka D, Wikonkal N, Ostorhazi E, John S, Paulsson M, Smyth N, Pasztoi M, Buzas EI, Szipocs R, Kolonics A, Temesvari E, Karpati S; J Invest Dermatol. 2014 Jan;134(1):105-11. doi: 10.1038/jid.2013.307. Epub 2013 Jul 24.

Abstract Recently, a transglutaminase 3 knockout (TGM3/KO) mouse was generated that showed impaired hair development, but no gross defects in the epidermal barrier,... Read More

Structural elucidation of full-length nidogen and the laminin-nidogen complex in solution

January 1, 2014publicationsPatel TR, Bernards C, Meier M, McEleney K, Winzor DJ, Koch M, Stetefeld J; Matrix Biol. 2014 Jan;33:60-7. doi: 10.1016/j.matbio.2013.07.009. Epub 2013 Aug 12.

Abstract Nidogen-1 is a key basement membrane protein that is required for many biological activities. It is one of the central elements in organizing... Read More

The innate immune system as mediator of systemic DNA damage responses

November 13, 2013A7 SCHUMACHERErmolaeva M, Schumacher B; Commun Integr Biol. 2013 Nov 13;6(6):e26926. doi: 10.4161/cib.26926. eCollection 2013.

Abstract DNA damage causally contributes to cancer development and tissue degeneration with aging.(1) Cellular DNA damage responses (DDR) mediate cell cycle arrest to allow... Read More

Tumor necrosis factor receptor signaling in keratinocytes triggers interleukin-24-dependent psoriasis-like skin inflammation in mice

November 7, 2013A4 PASPARAKIS Kumari S, Bonnet MC, Ulvmar MH, Wolk K, Karagianni N, Witte E, Uthoff-Hachenberg C, Renauld JC, Kollias G, Toftgard R, Sabat R, Pasparakis M, Haase I; Immunity. 2013 Nov 14;39(5):899-911. doi: 10.1016/j.immuni.2013.10.009. Epub 2013 Nov 7.

Abstract Psoriasis is a common chronic inflammatory skin disease with a prevalence of about 2% in the Caucasian population. Tumor necrosis factor (TNF) plays... Read More

SFB 829 PhD student & Postdoc Retreat 2013 with Matthias Schäfer (ETH Zürich, Switzerland) and Sandra Iden (SFB 829 PI)

October 24, 2013Annual Retreat

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