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The weakest link: a new paradigm for stabilizing the integrin-actin connection

Morgner J, Wickström SA Cell Cycle 2013 Sep;12(18):2929-30 PMID: 23974089 Abstract

Doxycycline-induced expression of transgenic human tumor necrosis factor α in adult mice results in psoriasis-like arthritis

Retser E, Schied T, Skryabin BV, Vogl T, Kanczler JM, Hamann N, Niehoff A, Hermann S, Eisenblätter M, Wachsmuth L, Pap T, van Lent...   Read More

Age-related bone deterioration is diminished by disrupted collagen sensing in integrin α2β1 deficient mice

B3 ECKES KRIEGStange R, Kronenberg D, Timmen M, Everding J, Hidding H, Eckes B, Hansen U, Holtkamp M, Karst U, Pap T, Raschke MJ; Bone. 2013 Sep;56(1):48-54. doi: 10.1016/j.bone.2013.05.003. Epub 2013 May 13.

Abstract Collagen binding integrins are of essential importance in the crosstalk between cells and the extracellular matrix. Integrin α2β1 is a major receptor for...   Read More

CD49b-dependent establishment of T helper cell memory

B3 ECKES KRIEGHanazawa A, Hayashizaki K, Shinoda K, Yagita H, Okumura K, Löhning M, Hara T, Tani-ichi S, Ikuta K, Eckes B, Radbruch A, Tokoyoda K, Nakayama T; Immunol Cell Biol. 2013 Sep;91(8):524-31. doi: 10.1038/icb.2013.36. Epub 2013 Jul 30.

Abstract CD4 T cells play a key role in immunological memory. We have demonstrated that professional memory CD4 T cells reside and rest in...   Read More

Systemic sclerosis with multiple nodules: characterization of the extracellular matrix

B3 ECKES KRIEGMoinzadeh P, Agarwal P, Bloch W, Orteu C, Hunzelmann N, Eckes B, Krieg T; Arch Dermatol Res. 2013 Sep;305(7):645-52. doi: 10.1007/s00403-013-1383-0. Epub 2013 Jul 9.

Abstract Systemic sclerosis (SSc) is still an enigmatic disease of unknown etiology, although the pathophysiology is thought to be based on vascular alterations as...   Read More

DNA damage in germ cells induces an innate immune response that triggers systemic stress resistance

A7 SCHUMACHERErmolaeva MA, Segref A, Dakhovnik A, Ou HL, Schneider JI, Utermöhlen O, Hoppe T, Schumacher B.

Abstract DNA damage responses have been well characterized with regard to their cell-autonomous checkpoint functions leading to cell cycle arrest, senescence and apoptosis. In...   Read More

aPKCλ controls epidermal homeostasis and stem cell fate through regulation of division orientation

A1 NIESSENNiessen MT, Scott J, Zielinski JG, Vorhagen S, Sotiropoulou PA, Blanpain C, Leitges M, Niessen CM; J Cell Biol. 2013 Sep 16;202(6):887-900. doi: 10.1083/jcb.201307001. Epub 2013 Sep 9.

PMID: 24019538 Abstract The atypical protein kinase C (aPKC) is a key regulator of polarity and cell fate in lower organisms. However, whether mammalian...   Read More

Gremlin-1 associates with fibrillin microfibrils in vivo and regulates mesothelioma cell survival through transcription factor slug

B12 SENGLE Tamminen JA, Parviainen V, Rönty M, Wohl AP, Murray L, Joenväärä S, Varjosalo M, Leppäranta O, Ritvos O, Sengle G, Renkonen R, Myllärniemi M, Koli K; Oncogenesis. 2013 Aug 26;2:e66. doi: 10.1038/oncsis.2013.29.

Abstract Malignant mesothelioma is a form of cancer that is highly resistant to conventional cancer therapy for which no major therapeutic advances have been...   Read More

T-cadherin is essential for adiponectin-mediated revascularization

Parker-Duffen JL, Nakamura K, Silver M, Kikuchi R, Tigges U, Yoshida S, Denzel MS, Ranscht B, Walsh K J. Biol. Chem. 2013 Aug;288(34):24886-97 PMID:...   Read More

Absence of the basement membrane component nidogen 2, but not of nidogen 1, results in increased lung metastasis in mice (2012)

publicationsMokkapati, S., Bechtel, M., Reibetanz, M., Miosge, N., and Nischt, R., J Histochem Cytochem. 2012 Apr;60(4):280-9. doi: 10.1369/0022155412436586. Epub 2012 Jan 19.

Abstract Nidogen 1 and 2 are ubiquitous basement membrane (BM) components. They show a divergent expression pattern in certain adult tissues with a prominent...   Read More

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