Vascular endothelial insulin/IGF-1 signaling controls skin wound vascularization

April 4, 2012A1 NIESSEN A5 BRÜNING/NIESSEN Aghdam SY, Eming SA, Willenborg S, Neuhaus B, Niessen CM, Partridge L, Krieg T, Bruning JC, Biochem Biophys Res Commun. 2012 May 4;421(2):197-202. doi: 10.1016/j.bbrc.2012.03.134. Epub 2012 Apr 4.

Abstract Type 2 diabetes mellitus affects 6% of western populations and represents a major risk factor for the development of skin complications, of which... Read More

Cell polarity proteins and cancer

March 23, 2012A10 IDENEllenbroek, S.I.J., Iden, S., Collard, J.G., Semin Cancer Biol. 2012 Jun;22(3):208-15. doi: 10.1016/j.semcancer.2012.02.012. Epub 2012 Mar 23.

Abstract Cell polarity is essential in many biological processes and required for development as well as maintenance of tissue integrity. Loss of polarity... Read More

Nonsense mutations in the COX1 subunit impair the stability of respiratory chain complexes rather than their assembly

March 7, 2012A14 WIESNER

Hornig-Do HT, Tatsuta T, Buckermann A, Bust M, Kollberg G, Rötig A, Hellmich M, Nijtmans L, Wiesner RJ EMBO J. 2012 Mar;31(5):1293-307 PMID: 22252130... Read More

aPKC phosphorylates JAM-A at Ser285 to promote cell contact maturation and tight junction formation

March 5, 2012A10 IDENIden, S., Misselwitz, S., Peddibhotla, S., Tuncay, H., Rehder, D., Gerke, V., Robenek, H., Suzuki, A., Ebnet, K., J Cell Biol. 2012 Mar 5;196(5):623-39. doi: 10.1083/jcb.201104143. Epub 2012 Feb 27

Abstract The PAR-3-atypical protein kinase C (aPKC)-PAR-6 complex has been implicated in the development of apicobasal polarity and the formation of tight junctions... Read More

The p53 network: cellular and systemic DNA damage responses in aging and cancer

March 3, 2012A7 SCHUMACHER Reinhardt HC, Schumacher B. Trends Genet. 2012 Mar;28(3):128-36.

Abstract Genome instability contributes to cancer development and accelerates age-related pathologies as evidenced by a variety of congenital cancer susceptibility and progeroid syndromes that... Read More

Stem cell dynamics in sebaceous gland morphogenesis in mouse skin

March 1, 2012A3 NIEMANNFrances, D., and Niemann. C., Dev Biol. 2012 Mar 1;363(1):138-46. doi: 10.1016/j.ydbio.2011.12.028. Epub 2011 Dec 27.

Abstract The hair follicle (HF) and the sebaceous gland (SG) constitute the two integral parts of the pilosebaceous unit and significantly contribute to the... Read More

Role of NF-κB in epithelial biology

March 1, 2012A4 PASPARAKISPasparakis, M., Immunol Rev. 2012 Mar;246(1):346-58. doi: 10.1111/j.1600-065X.2012.01109.x.

Abstract Since its discovery, nuclear factor-κB (NF-κB) has been recognized as a critical regulator of immune responses. While early studies focused on studying the... Read More

Dwarfism in mice lacking collagen-binding integrins α2β1 and α11β1 is caused by severely diminished IGF-1 levels

February 24, 2012A5 BRÜNING/NIESSEN B3 ECKES KRIEGBlumbach, K., Niehoff, A., Belgardt, B.F., Ehlen, H.W., Schmitz, M., Hallinger, R., Schulz, J.N., Brüning, J.C., Krieg, T., Schubert, M., Gullberg, D., and Eckes, B., J Biol Chem. 2012 Feb 24;287(9):6431-40. doi: 10.1074/jbc.M111.283119. Epub 2011 Dec 30.

Abstract Mice with a combined deficiency in the α2β1 and α11β1 integrins lack the major receptors for collagen I. These mutants are born with... Read More

TCF/Lef1-mediated control of lipid metabolism regulates skin barrier function

February 1, 2012A1 NIESSENFehrenschild, D., Galli, U., Breiden, B., Bloch, W., Schettina, P., Brodesser, S., Michels, C., Günschmann, C., Sandhoff, K., Niessen, C.M., and Niemann, C., J Invest Dermatol. 2012 Feb;132(2):337-45. doi: 10.1038/jid.2011.301. Epub 2011 Sep 22.

Abstract Defects in the function of the skin barrier are associated with a wide variety of skin diseases, many of which are not well... Read More

A function for Rac1 in the terminal differentiation and pigmentation of hair

January 24, 2012A3 NIEMANN A5 BRÜNING/NIESSEN Behrendt K, Klatte J, Pofahl R, Bloch W, Smyth N, Tscharntke M, Krieg T, Paus R, Niessen CM, Niemann C, Brakebusch C, Haase I; J Cell Sci. 2012 Feb 15;125(Pt 4):896-905. doi: 10.1242/jcs.091868. Epub 2012 Jan 24.

Abstract The small GTPase Rac1 is ubiquitously expressed in proliferating and differentiating layers of the epidermis and hair follicles. Previously, Rac1 was shown to... Read More

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