Abstract Type 2 diabetes mellitus affects 6% of western populations and represents a major risk factor for the development of skin complications, of which... Read More
Abstract Cell polarity is essential in many biological processes and required for development as well as maintenance of tissue integrity. Loss of polarity... Read More
Hornig-Do HT, Tatsuta T, Buckermann A, Bust M, Kollberg G, Rötig A, Hellmich M, Nijtmans L, Wiesner RJ EMBO J. 2012 Mar;31(5):1293-307 PMID: 22252130... Read More
Abstract The PAR-3-atypical protein kinase C (aPKC)-PAR-6 complex has been implicated in the development of apicobasal polarity and the formation of tight junctions... Read More
Abstract Genome instability contributes to cancer development and accelerates age-related pathologies as evidenced by a variety of congenital cancer susceptibility and progeroid syndromes that... Read More
Abstract The hair follicle (HF) and the sebaceous gland (SG) constitute the two integral parts of the pilosebaceous unit and significantly contribute to the... Read More
Abstract Since its discovery, nuclear factor-κB (NF-κB) has been recognized as a critical regulator of immune responses. While early studies focused on studying the... Read More
Abstract Mice with a combined deficiency in the α2β1 and α11β1 integrins lack the major receptors for collagen I. These mutants are born with... Read More
Abstract Defects in the function of the skin barrier are associated with a wide variety of skin diseases, many of which are not well... Read More
Abstract The small GTPase Rac1 is ubiquitously expressed in proliferating and differentiating layers of the epidermis and hair follicles. Previously, Rac1 was shown to... Read More
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