The adapter protein FADD protects epidermal keratinocytes from necroptosis in vivo and prevents skin inflammation

October 28, 2011A4 PASPARAKISBonnet MC, Preukschat D, Welz PS, van Loo G, Ermolaeva M, Bloch W, Haase I, Pasparakis M (2011) Immunity ,2011 Oct 28;35(4):572-82. Epub 2011 Oct 13.

Abstract Epidermal keratinocytes provide an essential structural and immunological barrier forming the first line of defense against potentially pathogenic microorganisms. Mechanisms regulating barrier integrity... Read More

Vitamin D is required for IFN-gamma-mediated antimicrobial activity of human macrophages

October 12, 2011B13 FABRIFabri, M., Stenger, S., Shin, D.M., Yuk, J.M., Liu, P.T., Realegeno, S., Lee, H.M., Krutzik, S.R., Schenk, M., Sieling, P.A., et al., Sci Transl Med. 2011 Oct 12;3(104):104ra102. doi: 10.1126/scitranslmed.3003045.

Abstract Control of tuberculosis worldwide depends on our understanding of human immune mechanisms, which combat the infection. Acquired T cell responses are critical for... Read More

Basement membrane diseases in zebrafish

October 5, 2011A9 HAMMERSCHMIDT Feitosa, N., Richardson, R., Bloch, W. and Hammerschmidt, M; Methods Cell Biol. 105, 191-222

Abstract Basement membranes (BMs) are a complex, sheet-like network of specialized extracellular matrix that underlies epithelial cells and surrounds muscle cells. They provide adherence... Read More

The loss of α2β1 integrin suppresses joint inflammation and cartilage destruction in mouse models of rheumatoid arthritis

September 28, 2011B3 ECKES KRIEG Peters MA, Wendholt D, Strietholt S, Frank S, Pundt N, Korb A, Joosten LAB, van den Berg WB, Kollias G, Eckes B, Pap T. , Arthritis Rheum 2011; accepted 16 September

Abstract OBJECTIVE: Integrin α2β1 functions as a major receptor for type I collagen on different cell types, including fibroblasts and inflammatory cells. Although in... Read More

TCF/Lef1 activity controls establishment of diverse stem and progenitor cell compartments in mouse epidermis

September 27, 2011A3 NIEMANN Petersson M, Brylka H, Kraus A, John S, Rappl G, Schettina P, and Niemann C. (2011) EMBO J. 30: 3004-3018.

Abstract Mammalian epidermis consists of the interfollicular epidermis, hair follicles (HFs) and associated sebaceous glands (SGs). It is constantly renewed by stem and progenitor... Read More

CF/Lef1 mediated control of lipid metabolism regulates skin barrier function

September 27, 2011A3 NIEMANN Fehrenschild D, Galli U, Breiden B, Bloch W, Schettina P, Brodesser, S, Michels C, Günschmann, C, Sandhoff K, Niessen C, and Niemann C. J Invest Dermatol. Sept 2011.

Abstract Defects in the function of the skin barrier are associated with a wide variety of skin diseases, many of which are not well... Read More

Laminin-332 coordinates mechanotransduction and growth cone bifurcation in sensory neurons

September 12, 2011publications Chiang, LY., J. Hu, K. Poole, B.E. Oliveira, N. Duarte, A.B. Sierra, L. Bruckner-Tuderman, M. Koch, and G.R. Lewin. 2011. Nat. Neurosci 14, 993–1000

Abstract: Laminin-332 is a major component of the dermo-epidermal skin basement membrane and maintains skin integrity. The transduction of mechanical force into electrical signals... Read More

Extracellular matrix in angiogenesis: dynamic structures with translational potential (2011)

August 24, 2011B7 EMING Eming SA, Hubbell JA, Exp Dermatol 20(7):605-1.

Abstract: The vascular network is an integral component of most organs. Beyond assuring an adequate supply of oxygen and nutrients for normal tissue function,... Read More

Sealing the gap between nuclear DNA damage and longevity (2009)

August 24, 2011A7 SCHUMACHER B15 HOEIJMAKERS Schumacher B, Hoeijmakers JH, Garinis GA, Mol Cell Endocrinol. 2009 Feb 5;299(1):112-7. Epub 2008 Nov 5.

Abstract: A number of progeroid syndromes with defects in the cellular response to DNA damage suggest that progressive genome instability represents an important aspect... Read More

Persistent transcription-blocking DNA lesions trigger somatic growth attenuation associated with longevity (2009)

August 24, 2011A5 BRÜNING/NIESSEN A7 SCHUMACHER B15 HOEIJMAKERS Garinis GA, Uittenboogaard LM, Stachelscheid H, Fousteri M, van Ijcken W, Breit TM, van Steeg H, Mullenders LHF, van der Horst GTJ, Brüning JC, Niessen CM, Hoeijmakers JHJ and Schumacher B, Nature Cell Biol. 2009 May;11(5):604-15.

Abstract: The accumulation of stochastic DNA damage throughout an organism’s lifespan is thought to contribute to ageing. Conversely, ageing seems to be phenotypically reproducible... Read More

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