Involvement of global genome repair, transcription coupled repair, and chromatin remodeling in UV DNA damage response changes during development (2010)

August 24, 2011A7 SCHUMACHER B15 HOEIJMAKERS Lans H, Marteijn JA, Schumacher B, Hoeijmakers JH, Jansen G, Vermeulen W., PLoS Genet. 2010 May 6;6:e1000941.

Abstract: Nucleotide Excision Repair (NER), which removes a variety of helix-distorting lesions from DNA, is initiated by two distinct DNA damage-sensing mechanisms. Transcription Coupled... Read More

Next Generation Sequencing of miRNAs – Strategies, Resources and Methods (2010)

August 24, 2011A7 SCHUMACHER Motameny S, Wolters S, Nürnberg P, Schumacher B., Genes. 2010; 1(1):70-84.

Abstract: miRNAs constitute a family of small RNA species that have been demonstrated to play a central role in regulating gene expression in many... Read More

Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity (2010)

August 24, 2011A7 SCHUMACHER Schwer B, Schumacher B, Lombard DB, Xiao C, Kurtev MV, Gao J, Schneider JI, Chai H, Bronson RT, Tsai LH, Deng CX, Alt FW. Proc Natl Acad Sci U S A. 2010 Nov 22.

Abstract: In yeast, Sir2 family proteins (sirtuins) regulate gene silencing, recombination, DNA repair, and aging via histone deacetylation. Most of the seven mammalian sirtuins... Read More

Annexin-A5 assembled into two-dimensional arrays promotes cell membrane repair (2011)

August 23, 2011publications Bouter A, Gounou C, Bérat R, Tan S, Gallois B, Granier T, d'Estaintot BL, Pöschl E, Brachvogel B, Brisson AR. Nat Commun. 2011;2:270.

Abstract: Eukaryotic cells possess a universal repair machinery that ensures rapid resealing of plasma membrane disruptions. Before resealing, the torn membrane is submitted to... Read More

The mitochondrial electron transport chain is dispensable for proliferation and differentiation of epidermal progenitor cells

August 22, 2011A14 WIESNER B3 ECKES KRIEG

Baris OR, Klose A, Kloepper JE, Weiland D, Neuhaus JF, Schauen M, Wille A, Müller A, Merkwirth C, Langer T, Larsson NG, Krieg T,... Read More

Constitutive IKK2 activation in intestinal epithelial cells induces intestinal tumors in mice

August 19, 2011A4 PASPARAKIS Vlantis K, Wullaert A, Sasaki Y, Schmidt-Supprian M, Rajewsky K, Roskams T, Pasparakis M., J Clin Invest. 2011, 121(7):2781-93

Abstract Many cancers display increased NF-κB activity, and NF-κB inhibition is known to diminish tumor development in multiple mouse models, supporting an important role... Read More

Collagen XXVIII is a distinctive component of the peripheral nervous system nodes of ranvier and surrounds nonmyelinating glial cells (2010)

August 18, 2011B2 WAGENER/ PAULSSON Grimal, S., Puech, S., Wagener, R., Ventéo, S., Carroll, P., Fichard-Carroll A. 2010. Glia. 58, 1977-87.

Abstract: Growing evidence indicates that collagens perform crucial functions during the development and organization of the nervous system. Collagen XXVIII is a recently discovered... Read More

Differential and restricted expression of novel collagen VI chains in mouse (2011)

August 18, 2011B2 WAGENER/ PAULSSON Gara, S.K., Grumati, P., Squarzoni, S., Sabatelli, P., Urciuolo, A., Bonaldo, P., Paulsson, M., Wagener, R., Matrix Biol. 30, 248-57

Abstract: Recently, three novel collagen VI chains, α4, α5 and α6, were identified. These are thought to substitute for the collagen VI α3 chain,... Read More

Ucmaa (Grp-2) is required for zebrafish skeletal development. Evidence for a functional role of its glutamate ?-carboxylation (2011)

August 18, 2011B2 WAGENER/ PAULSSON Neacsu, C.D., Grosch, M., Tejada, M., Winterpacht, A., Paulsson, M., Wagener, R., Tagariello, A. 2011. Matrix Biol. Aug 2011 [Epub ahead of print]

Abstract: UCMA (alternatively named GRP) is a novel member of the family of γ-carboxyglutamate (Gla) containing proteins that is mainly expressed in cartilage. We... Read More

Migration of epithelial cells on laminins: RhoA antagonizes directionally persistent migration (2011)

August 15, 2011B4 ZIGRINO MAUCH Zhang Z, Chometon G, Wen T, Qu H, Mauch C, Krieg T, Aumailley M. Eur J Cell Biol. Jan;90(1):1-12, 2011.

Abstract Spatial and temporal expression of laminin isoforms is assumed to provide specific local information to neighboring cells. Here, we report the remarkably selective... Read More

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