Epidermal Insulin/IGF-1 signaling control interfollicular morphogenesis and proliferative potential via Rac activation (2008)

A5 BRÜNING/NIESSEN Stachelscheid. H.*, Ibrahim, H.*, Koch, L., Schmitz, A., Tscharntke, M., Wunderlich F.T., Scott, J. Michels, C., Haase I., Wickenhauser, C., Brüning, J and Niessen C.M. EMBO J. 27:2091-101.

Abstract The lifelong self-renewal of the epidermis is driven by a progenitor cell population with high proliferative potential. To date, the upstream signals that...   Read More

CD44 regulates tight junction assembly and barier function (2011)

A1 NIESSEN Kirschner,, N, Haftek, M, Niessen, C.M., Behne, M.J., Furuse, M., Moll, I. and Brandner J.M. J. Invest. Derm 2011 Apr;131(4):932-43

Abstract Upon barrier disturbance, adult CD44 knockout (KO) mice show delayed recovery of epidermal barrier function. This correlates with the loss of apical polarization...   Read More

The disintegrin/metalloproteinase ADAM10 is essential for the Notch -mediated development and integrity of the epidermis (2011 )

A1 NIESSEN Weber, S., Niessen, M, Prox, J. , Luellmann-Rauch, ,Schmitz, A., Schwanbeck, R., Blobel, C.P., de Strooper, B., Niessen, C.M.+ and Saftig, P.+ Development 138(3):495-505.

Abstract The disintegrin and metalloproteinase Adam10 has been implicated in the regulation of key signaling pathways that determine skin morphogenesis and homeostasis. To address...   Read More

An adhesion independent, aPKC dependent function for cadherins in morphogenetic movements (2009)

A1 NIESSEN Seifert, K., Ibrahim H., Winklbauer R. and Niessen C.M. J. Cell Sci.122: 2514-23.

Abstract Cadherin shedding affects migration and occurs in development and cancer progression. By examining the in vivo biological function of the extracellular cadherin domain...   Read More

Cadherin mediated regulation of tight junctions in stratifying epithelia (2009)

A1 NIESSEN Michels, C., Yadranji, S. and Niessen C.M., N Y Acad Sci. 1165:163-8.

Abstract In recent years several seminal breakthroughs have revealed that tight junctions not only regulate barrier properties of simple epithelial cells but also play...   Read More

Classical cadherins regulate desmosome formation (2009)

A1 NIESSEN Michels, C., Buchta T., Bloch W., Krieg, T, and Niessen C.M. J. Invest. Derm. 129:2072-5


FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation

A4 PASPARAKIS Welz PS, Wullaert A, Vlantis K, Kondylis V, Fernández-Majada V, Ermolaeva M, Kirsch P, Sterner-Kock A, van Loo G, Pasparakis M., Nature. 2011 Jul 31. doi: 10.1038/nature10273

Abstract Intestinal immune homeostasis depends on a tightly regulated cross talk between commensal bacteria, mucosal immune cells and intestinal epithelial cells (IECs). Epithelial barrier...   Read More

The Mitochondrial Electron Transport Chain is Dispensable for Proliferation and Differentiation of Epidermal Progenitor Cells

publications Baris OR, Klose A, Kloepper JE, Weiland D, Neuhaus JF, Schauen M, Wille A, Müller A, Merkwirth C, Langer T, Larsson NG, Krieg T, Tobin DJ, Paus R, Wiesner RJ. Stem Cells. 2011 Jul 20.

Abstract Tissue stem cells, as well as germ line or embryonic stem cells, were shown to have reduced oxidative metabolism, which was proposed to...   Read More

Z2 Bloch & Niessen

An important aspect of the CRC 829 remains the generation and careful cell biological and ultrastructural analysis of mouse and cell culture models that...   Read More

B9 Partridge & Krieg

Abstract We recently found that incidence of ulcerative dermatitis is markedly reduced in mice deficient for the insulin receptor substrate (IRS)-1 gene. These mice...   Read More

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