Abstract The lifelong self-renewal of the epidermis is driven by a progenitor cell population with high proliferative potential. To date, the upstream signals that... Read More
Abstract Upon barrier disturbance, adult CD44 knockout (KO) mice show delayed recovery of epidermal barrier function. This correlates with the loss of apical polarization... Read More
Abstract The disintegrin and metalloproteinase Adam10 has been implicated in the regulation of key signaling pathways that determine skin morphogenesis and homeostasis. To address... Read More
Abstract Cadherin shedding affects migration and occurs in development and cancer progression. By examining the in vivo biological function of the extracellular cadherin domain... Read More
Abstract In recent years several seminal breakthroughs have revealed that tight junctions not only regulate barrier properties of simple epithelial cells but also play... Read More
Abstract Intestinal immune homeostasis depends on a tightly regulated cross talk between commensal bacteria, mucosal immune cells and intestinal epithelial cells (IECs). Epithelial barrier... Read More
Abstract Tissue stem cells, as well as germ line or embryonic stem cells, were shown to have reduced oxidative metabolism, which was proposed to... Read More
An important aspect of the CRC 829 remains the generation and careful cell biological and ultrastructural analysis of mouse and cell culture models that... Read More
Abstract We recently found that incidence of ulcerative dermatitis is markedly reduced in mice deficient for the insulin receptor substrate (IRS)-1 gene. These mice... Read More
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