Archives

B7 Eming

Abstract Macrophages and polymorphonuclear leukocytes are key elements of the repair response following tissue injury. However, their role in skin repair and homeostasis is...   Read More

B2 Wagener Paulsson

Structure and function of microfibrillar and filamentous suprastructures in the dermis Extracellular microfibrillar and filamentous suprastructures control tissue integrity and cell fate. We will...   Read More

A9 Hammerschmidt

Genetic analysis of epidermal development and homeostasis in zebrafish Using zebrafish genetics, we have identified a p53/p63-Notch-Caspase 3 pathway regulating epidermal renewal by promoting...   Read More

A6 Benzing …

Phosphorylation-dependent regulation of AATF controls p53-dependent apoptosis in the UV-induced DNA damage response of the skin We identified AATF as a regulator of the...   Read More

MTERF4 Regulates Translation by Targeting the Methyltransferase NSUN4 to the Mammalian Mitochondrial Ribosome

publications Cámara Y, Asin-Cayuela J, Park CB, Metodiev MD, Shi Y, Ruzzenente B, Kukat C, Habermann B, Wibom R, Hultenby K, Franz T, Erdjument-Bromage H, Tempst P, Hallberg BM, Gustafsson CM, Larsson NG. Cell Metab. 2011 May 4;13(5):527-39.

Abstract Mammalian mtDNA is packaged in DNA-protein complexes denoted mitochondrial nucleoids. The organization of the nucleoid is a very fundamental question in mitochondrial biology...   Read More

Z1 Niessen

The central office was and is the communication and administrative centre of the CRC 829. The office has two main aims: (1) represent the...   Read More

B10 Haase

Regulation of skin inflammation by epidermal keratinocytes We have found that the activity of NFkB in the epidermis determines the strength of inflammatory reactions...   Read More

Ultra-deep sequencing of mouse mitochondrial DNA: mutational patterns and their origins

Ameur A, Stewart JB, Freyer C, Hagström E, Ingman M, Larsson NG, Gyllensten U PLoS Genet. 2011 Mar;7(3):e1002028 PMID: 21455489 Abstract Somatic mutations of...   Read More

Prodomains of transforming growth factor beta (TGFbeta) superfamily members specify different functions: extracellular matrix interactions and growth factor bioavailability

B12 SENGLESengle, G., Ono, R.N., Sasaki, T., and Sakai, L.Y., J Biol Chem. 2011 Feb 18;286(7):5087-99. doi: 10.1074/jbc.M110.188615. Epub 2010 Dec 6.

Abstract The specific functions of the prodomains of TGFβ superfamily members are largely unknown. Interactions are known between prodomains of TGFβ-1-3 and latent TGFβ-binding...   Read More

Role of autophagy in the host response to microbial infection and potential for therapy

B13 FABRIFabri, M., Realegeno, S.E., Jo, E.K., and Modlin, R.L., Curr Opin Immunol. 2011 Feb;23(1):65-70. doi: 10.1016/j.coi.2010.10.010. Epub 2010 Nov 9

Abstract   There is compelling evidence demonstrating a key role for autophagy in host defense against microbial infections. Induction and regulation of autophagy involves...   Read More

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