Abstract Macrophages and polymorphonuclear leukocytes are key elements of the repair response following tissue injury. However, their role in skin repair and homeostasis is... Read More
Structure and function of microfibrillar and filamentous suprastructures in the dermis Extracellular microfibrillar and filamentous suprastructures control tissue integrity and cell fate. We will... Read More
Genetic analysis of epidermal development and homeostasis in zebrafish Using zebrafish genetics, we have identified a p53/p63-Notch-Caspase 3 pathway regulating epidermal renewal by promoting... Read More
Phosphorylation-dependent regulation of AATF controls p53-dependent apoptosis in the UV-induced DNA damage response of the skin We identified AATF as a regulator of the... Read More
Abstract Mammalian mtDNA is packaged in DNA-protein complexes denoted mitochondrial nucleoids. The organization of the nucleoid is a very fundamental question in mitochondrial biology... Read More
The central office was and is the communication and administrative centre of the CRC 829. The office has two main aims: (1) represent the... Read More
Regulation of skin inflammation by epidermal keratinocytes We have found that the activity of NFkB in the epidermis determines the strength of inflammatory reactions... Read More
Ameur A, Stewart JB, Freyer C, Hagström E, Ingman M, Larsson NG, Gyllensten U PLoS Genet. 2011 Mar;7(3):e1002028 PMID: 21455489 Abstract Somatic mutations of... Read More
Abstract The specific functions of the prodomains of TGFβ superfamily members are largely unknown. Interactions are known between prodomains of TGFβ-1-3 and latent TGFβ-binding... Read More
Abstract There is compelling evidence demonstrating a key role for autophagy in host defense against microbial infections. Induction and regulation of autophagy involves... Read More
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