A unique chromatin signature uncovers early developmental enhancers in humans

Rada-Iglesias A, Bajpai R, Swigut T, Brugmann SA, Flynn RA, Wysocka J Nature 2011 Feb;470(7333):279-83 PMID: 21160473 Abstract Cell-fate transitions involve the integration of...   Read More

Genetic analyses of integrin signaling

A11 WICKSTRÖMWickström, S., Radovanac, K., Fässler, R., Cold Spring Harb Perspect Biol. 2011 Feb 1;3(2). pii: a005116. doi: 10.1101/cshperspect.a005116

Abstract   The development of multicellular organisms, as well as maintenance of organ architecture and function, requires robust regulation of cell fates. This is...   Read More

A secreted variant of cartilage oligomeric matrix protein carrying a chondrodysplasia-causing mutation (p.H587R) disrupts collagen fibrillogenesis

B11 BAUMANN/SENGLEHansen, U., Platz, N., Becker, A., Bruckner, P., Paulsson, M., and Zaucke ,F., Arthritis Rheum. 2011 Jan;63(1):159-67. doi: 10.1002/art.30073

Abstract OBJECTIVE: Mutations in human cartilage oligomeric matrix protein (COMP) cause multiple epiphyseal dysplasia or pseudoachondroplasia. Electron microscopic analyses of patient biopsy tissue have...   Read More

T-cell cytokines differentially control human monocyte antimicrobial responses by regulating vitamin D metabolism

B13 FABRI Edfeldt, K., Liu, P.T., Chun, R., Fabri, M., Schenk, M., Wheelwright, M., Keegan, C., Krutzik, S.R., Adams, J.S., Hewison, M., et al., Proc Natl Acad Sci U S A. 2010 Dec 28;107(52):22593-8. doi: 10.1073/pnas.1011624108. Epub 2010 Dec 13.

Abstract We investigated the mechanisms by which T-cell cytokines are able to influence the Toll-like receptor (TLR)-induced, vitamin D-dependent antimicrobial pathway in human monocytes....   Read More

T-cadherin is critical for adiponectin-mediated cardioprotection in mice

Denzel MS, Scimia MC, Zumstein PM, Walsh K, Ruiz-Lozano P, Ranscht B J. Clin. Invest. 2010 Dec;120(12):4342-52 PMID: 21041950 Abstract The circulating, adipocyte-secreted hormone...   Read More

Nesprin-2 interacts with {alpha}-catenin and regulates Wnt signaling at the nuclear envelope

B7 EMING Neumann S, Schneider M, Daugherty RL, Gottardi CJ, Eming SA, Beijer A, Noegel AA, Karakesisoglou I, J Biol Chem. 2010 Nov 5;285(45):34932-8.

Abstract: Nesprins and emerin are structural nuclear envelope proteins that tether nuclei to the cytoskeleton. In this work, we identified the cytoskeleton-associated α-N/E-catenins as...   Read More

Integrin-linked kinase controls microtubule dynamics required for plasma membrane targeting of caveolae

A11 WICKSTRÖMWickström, S.A.*, Lange, A., Hess, M.J. Polleux, J., Spatz, J.P., Krüger, M., Pfaller, K., Lambacher, A., Bloch, W., Mann, M., Huber, L.A., and Fässler, R., Dev Cell. 2010 Oct 19;19(4):574-88. doi: 10.1016/j.devcel.2010.09.007.

Abstract Caveolae are specialized compartments of the plasma membrane that are involved in signaling, endocytosis, and cholesterol transport. Their formation requires the transport of...   Read More

DNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilization

publicationsReinhardt, H.C., Hasskamp, P., Schmedding, I., Morandell, S., van Vugt, M., Wang, X., Linding, R., Ong, S.E., Weaver, D., Carr, S.A., Yaffe, M.B., Mol Cell. 2010 Oct 8;40(1):34-49. doi: 10.1016/j.molcel.2010.09.018.

Abstract Following genotoxic stress, cells activate a complex kinase-based signaling network to arrest the cell cycle and initiate DNA repair. p53-defective tumor cells rewire...   Read More

Fibrillin-1 and -2 differentially modulate endogenous TGF-? and BMP bioavailability during bone formation

B12 SENGLENistala, H., Lee-Arteaga, S., Smaldone, S., Siciliano, G., Carta, L., Ono, R., Sengle, G., Arteaga- Solis, E., Levasseur, R., Ducy, P., Sakai, L., Karsenty, and G., Ramirez, F., J Cell Biol. 2010 Sep 20;190(6):1107-21. doi: 10.1083/jcb.201003089.

Abstract Extracellular regulation of signaling by transforming growth factor (TGF)-β family members is emerging as a key aspect of organ formation and tissue remodeling....   Read More

Integrin α2-deficient mice provide insights into specific functions of collagen receptors in the kidney

B3 ECKES KRIEG Girgert R, Martin M, Kruegel J, Miosge N, Temme J, Eckes B, Muller GA, Gross O., Fibrogenesis & Tissue Repair 2010, 3:19.

Background Integrins are important cellular receptors for collagens. Within the glomerulus, podocytes regulate the integrity of the glomerular basement membrane (GBM) by sensing the...   Read More

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