Epidermal insulin/IGF-1 signalling control interfollicular morphogenesis and proliferative potential through Rac activation

July 24, 2008A5 BRÜNING/NIESSEN

Stachelscheid H, Ibrahim H, Koch L, Schmitz A, Tscharntke M, Wunderlich FT, Scott J, Michels C, Wickenhauser C, Haase I, Brüning JC, Niessen CM... Read More

Targeting of bone morphogenetic protein growth factor complexes to fibrillin

May 16, 2008B12 SENGLE Sengle, G., Charbonneau, N.L., Ono, R.N., Sasaki, T., Alvarez, J., Keene, D.R., Bächinger H.P., and Sakai, L.Y., J Biol Chem. 2008 May 16;283(20):13874-88. doi: 10.1074/jbc.M707820200. Epub 2008 Mar 13.

Abstract Both latent transforming growth factor-beta (TGF-beta)-binding proteins fibrillins are components of microfibril networks, and both interact with members of the TGF-beta family of... Read More

Conserved mycobacterial lipoglycoproteins activate TLR2 but also require glycosylation for MHC class II-restricted T cell activation

May 1, 2008B13 FABRISieling, P.A., Hill, P.J., Dobos, K.M., Brookman, K., Kuhlman, A.M., Fabri, M., Krutzik, S.R., Rea, T.H., Heaslip, D.G., Belisle, J.T., et al., J Immunol. 2008 May 1;180(9):5833-42.

Abstract CD4(+) T cell clones derived from a leprosy lesion and patient blood were used to monitor the isolation and identification of an Ag... Read More

Integrin-linked kinase stabilizes myotendinous junctions and protects muscle from stress-induced damage

March 10, 2008A11 WICKSTRÖMWang, H.V., Chang, L.W., Brixius, K., Wickström, S.A, Montanez, E., Thievessen, I., Schwander, M., Müller, U., Bloch, W., Mayer, U., Fässler, R., J Cell Biol. 2008 Mar 10;180(5):1037-49. doi: 10.1083/jcb.200707175

Abstract Skeletal muscle expresses high levels of integrin-linked kinase (ILK), predominantly at myotendinous junctions (MTJs) and costameres. ILK binds the cytoplasmic domain of beta1... Read More

Broken hearts, woolly hair, and tattered skin: when desmosomal adhesion goes awry

November 5, 2007A12 BAZZI

Bazzi H, Christiano AM Curr. Opin. Cell Biol. 2007 Oct;19(5):515-20 PMID: 17951043 Abstract Desmosomal cadherins constitute the adhesive core of desmosomes. Different desmosomal cadherins... Read More

Inactivation of serine protease Matriptase1a by its inhibitor Hai1 is required for epithelial integrity of the zebrafish epidermis

September 10, 2007A9 HAMMERSCHMIDT

Carney TJ, von der Hardt S, Sonntag C, Amsterdam A, Topczewski J, Hopkins N, Hammerschmidt M Development 2007 Oct;134(19):3461-71 PMID: 17728346 Abstract Epithelial integrity... Read More

A calcium-gated lid and a large beta-roll sandwich are revealed by the crystal structure of extracellular lipase from Serratia marcescens (2007)

August 28, 2007B11 BAUMANN/SENGLEMeier, R., Drepper, T., Svensson, V.E., Jaeger, K-E. and Baumann, U., J Biol Chem. 2007 Oct 26;282(43):31477-83. Epub 2007 Aug 28.

Abstract Lipase LipA from Serratia marcescens is a 613-amino acid enzyme belonging to family I.3 of lipolytic enzymes that has an important biotechnological application... Read More

JAM-C regulates tight junctions and integrin-mediated cell adhesion and migration

August 13, 2007A10 IDENMandicourt, G., Iden, S., Ebnet, K., Aurrand-Lions, M., Imhof, B.A., J Biol Chem. 2007 Jan 19;282(3):1830-7. Epub 2006 Nov 12.

Abstract Junctional Adhesion Molecules (JAMs) have been described as major components of tight junctions in endothelial and epithelial cells. Tight junctions are crucial... Read More

The Wnt inhibitor, Dickkopf 4, is induced by canonical Wnt signaling during ectodermal appendage morphogenesis

May 7, 2007A12 BAZZI

Bazzi H, Fantauzzo KA, Richardson GD, Jahoda CA, Christiano AM Dev. Biol. 2007 May;305(2):498-507 PMID: 17397822 Abstract Ectodermal appendage morphogenesis requires continuous epithelial-mesenchymal cross-talk... Read More

Transcriptional profiling of developing mouse epidermis reveals novel patterns of coordinated gene expression

April 30, 2007A12 BAZZI

Bazzi H, Fantauzzo KA, Richardson GD, Jahoda CA, Christiano AM Dev. Dyn. 2007 Apr;236(4):961-70 PMID: 17330888 Abstract The mammalian epidermis is the first line... Read More

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