Dual role of inactivating Lef1 mutations in epidermis: tumor promotion and specification of tumor type

April 5, 2007A3 NIEMANN

Niemann C, Owens DM, Schettina P, Watt FM Cancer Res. 2007 Apr;67(7):2916-21 PMID: 17409394 Abstract The NH(2) terminus of LEF1 is frequently mutated in... Read More

A distinct PAR complex associates physically with VE-cadherin in vertebrate endothelial cells (2006)

October 20, 2006A10 IDENIden, S., Rehder, D., August, B., Suzuki, A., Noda, K., Nagafuchi, A., Wolburg-Buchholz, K., Wolburg, H., Ohno, S., Behrens, J., Vestweber, D., Ebnet, K., EMBO Rep. 2006 Dec;7(12):1239-46. Epub 2006 Oct 20.

Abstract A cell polarity complex consisting of partitioning defective 3 (PAR-3), atypical protein kinase C (aPKC) and PAR-6 has a central role in the... Read More

Junctional adhesion molecule-a participates in the formation of apico-basal polarity through different domains

August 13, 2006A10 IDENRehder, D., Iden, S., Nasdala, I., Wegener, J., Brickwedde, M.K., Vestweber, D., Ebnet, K., Exp Cell Res. 2006 Oct 15;312(17):3389-403. Epub 2006 Jul 21

Abstract Junctional adhesion molecule (JAM)-A is an integral membrane protein at tight junctions of epithelial cells which associates with the cell polarity protein... Read More

The molecular architecture of the metalloprotease FtsH

February 28, 2006B11 BAUMANN/SENGLEBieniossek, C., Schalch, T., Bumann, M., Meister, M., Meier, R., and Baumann, U., Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3066-71. Epub 2006 Feb 16.

Abstract The ATP-dependent integral membrane protease FtsH is universally conserved in bacteria. Orthologs exist in chloroplasts and mitochondria, where in humans the loss... Read More

Crossveinless 2 is an essential positive feedback regulator of Bmp signaling during zebrafish gastrulation

February 10, 2006A9 HAMMERSCHMIDT

Rentzsch F, Zhang J, Kramer C, Sebald W, Hammerschmidt M Development 2006 Mar;133(5):801-11 PMID: 16439480 Abstract Signaling by bone morphogenetic proteins (Bmps) plays a... Read More

Characterization of recombinant amino-terminal NC4 domain of human collagen IX: interaction with glycosaminoglycans and cartilage oligomeric matrix protein

June 4, 2004B11 BAUMANN/SENGLEPihlajamaa, T., Lankinen, H., Ylöstalo, J., Valmu, L., Jäälinoja, J., Zaucke, F., Spitznagel, L., Gösling, S., Puustinen, A., Mörgelin, M., Peränen, J., Maurer, P., Ala-Kokko, L., and Kilpeläinen, I., J Biol Chem. 2004 Jun 4;279(23):24265-73. Epub 2004 Mar 26.

Abstract The N-terminal NC4 domain of collagen IX is a globular structure projecting away from the surface of the cartilage collagen fibril. Several interactions... Read More

Characterization of a pseudoachondroplasia-associated mutation (His587–>Arg) in the C-terminal, collagen-binding domain of cartilage oligomeric matrix protein (COMP)

January 15, 2004B11 BAUMANN/SENGLE Spitznagel, L., Nitsche, D.P., Paulsson, M., Maurer, P., and Zaucke, F., Biochem J. 2004 Jan 15;377(Pt 2):479-87.

Abstract We have introduced a pseudoachondroplasia-associated mutation (His(587)–>Arg) into the C-terminal collagen-binding domain of COMP (cartilage oligomeric matrix protein) and recombinantly expressed the full-length... Read More

Indian hedgehog and beta-catenin signaling: role in the sebaceous lineage of normal and neoplastic mammalian epidermis

October 1, 2003A3 NIEMANN

Niemann C, Unden AB, Lyle S, Zouboulis ChC, Toftgård R, Watt FM Proc. Natl. Acad. Sci. U.S.A. 2003 Sep;100 Suppl 1:11873-80 PMID: 12917489 Abstract... Read More

Pseudoachondroplasia is caused through both intra- and extracellular pathogenic pathways

August 15, 2002B11 BAUMANN/SENGLEDinser, R., Zaucke, F., Kreppel, F., Hultenby, K., Kochanek, S., Paulsson, M., Maurer, P,. J Clin Invest. 2002 Aug;110(4):505-13.

Abstract Pseudoachondroplasia is a dominantly inherited chondrodysplasia associated with mutations in cartilage oligomeric matrix protein (COMP). Investigations into the pathogenesis of pseudoachondroplasia are hampered... Read More

Zebrafish DeltaNp63 is a direct target of Bmp signaling and encodes a transcriptional repressor blocking neural specification in the ventral ectoderm

May 17, 2002A9 HAMMERSCHMIDT

Bakkers J, Hild M, Kramer C, Furutani-Seiki M, Hammerschmidt M Dev. Cell 2002 May;2(5):617-27 PMID: 12015969 Abstract Bone morphogenetic proteins (Bmps) promote ventral specification... Read More

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