Niemann C, Owens DM, Schettina P, Watt FM Cancer Res. 2007 Apr;67(7):2916-21 PMID: 17409394 Abstract The NH(2) terminus of LEF1 is frequently mutated in... Read More
Abstract A cell polarity complex consisting of partitioning defective 3 (PAR-3), atypical protein kinase C (aPKC) and PAR-6 has a central role in the... Read More
Abstract Junctional adhesion molecule (JAM)-A is an integral membrane protein at tight junctions of epithelial cells which associates with the cell polarity protein... Read More
Abstract The ATP-dependent integral membrane protease FtsH is universally conserved in bacteria. Orthologs exist in chloroplasts and mitochondria, where in humans the loss... Read More
Rentzsch F, Zhang J, Kramer C, Sebald W, Hammerschmidt M Development 2006 Mar;133(5):801-11 PMID: 16439480 Abstract Signaling by bone morphogenetic proteins (Bmps) plays a... Read More
Abstract The N-terminal NC4 domain of collagen IX is a globular structure projecting away from the surface of the cartilage collagen fibril. Several interactions... Read More
Abstract We have introduced a pseudoachondroplasia-associated mutation (His(587)–>Arg) into the C-terminal collagen-binding domain of COMP (cartilage oligomeric matrix protein) and recombinantly expressed the full-length... Read More
Niemann C, Unden AB, Lyle S, Zouboulis ChC, Toftgård R, Watt FM Proc. Natl. Acad. Sci. U.S.A. 2003 Sep;100 Suppl 1:11873-80 PMID: 12917489 Abstract... Read More
Abstract Pseudoachondroplasia is a dominantly inherited chondrodysplasia associated with mutations in cartilage oligomeric matrix protein (COMP). Investigations into the pathogenesis of pseudoachondroplasia are hampered... Read More
Bakkers J, Hild M, Kramer C, Furutani-Seiki M, Hammerschmidt M Dev. Cell 2002 May;2(5):617-27 PMID: 12015969 Abstract Bone morphogenetic proteins (Bmps) promote ventral specification... Read More
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