publications

MPK-1/ERK pathway regulates DNA damage response during development through DAF-16/FOXO

Bianco JN, Schumacher B Nucleic Acids Res. 2018 Jul;46(12):6129-6139 PMID: 29788264 Abstract Ultraviolet (UV) induces distorting lesions to the DNA that can lead to...   Read More

Maintenance of Proteostasis by P Body-Mediated Regulation of eIF4E Availability during Aging in Caenorhabditis elegans

Rieckher M, Markaki M, Princz A, Schumacher B, Tavernarakis N Cell Rep 2018 Oct;25(1):199-211.e6 PMID: 30282029 Abstract Aging is accompanied by a pervasive collapse...   Read More

The Cdkn1a Mouse as a Tool to Study p53-Mediated Tumor Suppression

Torgovnick A, Heger JM, Liaki V, Isensee J, Schmitt A, Knittel G, Riabinska A, Beleggia F, Laurien L, Leeser U, Jüngst C, Siedek F,...   Read More

Fibrillin microfibrils and proteases, key integrators of fibrotic pathways

Zigrino P, Sengle G Adv. Drug Deliv. Rev. 2018 Apr; PMID: 29709492 Abstract Supramolecular networks composed of multi-domain ECM proteins represent intricate cellular microenvironments...   Read More

Odd skipped-related 1 identifies a population of embryonic fibro-adipogenic progenitors regulating myogenesis during limb development

Vallecillo-García P, Orgeur M, Vom Hofe-Schneider S, Stumm J, Kappert V, Ibrahim DM, Börno ST, Hayashi S, Relaix F, Hildebrandt K, Sengle G, Koch...   Read More

A homozygous missense variant in VWA2, encoding an interactor of the Fraser-complex, in a patient with vesicoureteral reflux

van der Ven AT, Kobbe B, Kohl S, Shril S, Pogoda HM, Imhof T, Ityel H, Vivante A, Chen J, Hwang DY, Connaughton DM,...   Read More

Adhesion forces and cortical tension couple cell proliferation and differentiation to drive epidermal stratification

Miroshnikova YA, Le HQ, Schneider D, Thalheim T, Rübsam M, Bremicker N, Polleux J, Kamprad N, Tarantola M, Wang I, Balland M, Niessen CM,...   Read More

The cartilage-specific lectin C-type lectin domain family 3 member A (CLEC3A) enhances tissue plasminogen activator-mediated plasminogen activation

Lau D, Elezagic D, Hermes G, Mörgelin M, Wohl AP, Koch M, Hartmann U, Höllriegl S, Wagener R, Paulsson M, Streichert T, Klatt AR...   Read More

TGFB1 is secreted through an unconventional pathway dependent on the autophagic machinery and cytoskeletal regulators

Nüchel J, Ghatak S, Zuk AV, Illerhaus A, Mörgelin M, Schönborn K, Blumbach K, Wickström SA, Krieg T, Sengle G, Plomann M, Eckes B...   Read More

Omics Approaches for Identifying Physiological Adaptations to Genome Instability in Aging

Edifizi D, Schumacher B Int J Mol Sci 2017 Nov;18(11) PMID: 29113067 Abstract DNA damage causally contributes to aging and age-related diseases. The declining...   Read More

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