A1 NIESSEN

The epidermal polarity protein Par3 is a non-cell autonomous suppressor of malignant melanoma

Mescher M, Jeong P, Knapp SK, Rübsam M, Saynisch M, Kranen M, Landsberg J, Schlaak M, Mauch C, Tüting T, Niessen CM, Iden S...   Read More

Epithelial barriers in murine skin during herpes simplex virus 1 infection: The role of tight junction formation

Rahn E, Thier K, Petermann P, Rübsam M, Staeheli P, Iden S, Niessen CM, Knebel-Mörsdorf D J. Invest. Dermatol. 2016 Dec; PMID: 27939379 Abstract...   Read More

Mechanical regulation of transcription controls Polycomb-mediated gene silencing during lineage commitment

Le HQ, Ghatak S, Yeung CY, Tellkamp F, Günschmann C, Dieterich C, Yeroslaviz A, Habermann B, Pombo A, Niessen CM, Wickström SA Nat. Cell...   Read More

Growth Retardation, Loss of Desmosomal Adhesion, and Impaired Tight Junction Function Identify a Unique Role of Plakophilin 1 In Vivo

Rietscher K, Wolf A, Hause G, Rother A, Keil R, Magin TM, Glass M, Niessen CM, Hatzfeld M J. Invest. Dermatol. 2016 Mar; PMID:...   Read More

The actin-binding protein EPS8 binds VE-cadherin and modulates YAP localization and signaling

Giampietro C, Disanza A, Bravi L, Barrios-Rodiles M, Corada M, Frittoli E, Savorani C, Lampugnani MG, Boggetti B, Niessen C, Wrana JL, Scita G,...   Read More

Ceramide synthase 4 regulates stem cell homeostasis and hair follicle cycling

Peters F, Vorhagen S, Brodesser S, Jakobshagen K, Brüning JC, Niessen CM, Krönke M J. Invest. Dermatol. 2015 Jun;135(6):1501-9 PMID: 25705848 Abstract Ceramides are...   Read More

Pathological implications of cadherin zonation in mouse liver

A1 NIESSENpublicationsHempel M, Schmitz A, Winkler S, Kucukoglu O, Brückner S, Niessen C, Christ B; Cell Mol Life Sci. 2015 Jul;72(13):2599-612. doi: 10.1007/s00018-015-1861-y. Epub 2015 Feb 17.

Abstract Both acute and chronic liver diseases are associated with ample re-modeling of the liver parenchyma leading to functional impairment, which is thus obviously...   Read More

Epidermal polarity genes in health and disease

Tellkamp F, Vorhagen S, Niessen CM Cold Spring Harb Perspect Med 2014 Dec;4(12):a015255 PMID: 25452423 Abstract The epidermis of the skin is a highly...   Read More

Mammalian aPKC/Par polarity complex mediated regulation of epithelial division orientation and cell fate

Vorhagen S, Niessen CM Exp. Cell Res. 2014 Nov;328(2):296-302 PMID: 25128813 Abstract Oriented cell division is a key regulator of tissue architecture and crucial...   Read More

Tropism-modified AAV vectors overcome barriers to successful cutaneous therapy

A1 NIESSENpublicationsSallach J, Di Pasquale G, Larcher F, Niehoff N, Rübsam M, Huber A, Chiorini J, Almarza D, Eming SA, Ulus H, Nishimura S, Hacker UT, Hallek M, Niessen CM, Büning H; Mol Ther. 2014 May;22(5):929-39. doi: 10.1038/mt.2014.14. Epub 2014 Jan 28.

Abstract Autologous human keratinocytes (HK) forming sheet grafts are approved as skin substitutes. Genetic engineering of HK represents a promising technique to improve engraftment...   Read More

  • Upcoming Events

    1. SFB Minisymposium – New Technologies for Dermatology

      August 29 @ 1:00 pm - 6:00 pm
    2. 4th German-French DNA Repair Meeting Cologne 2017

      September 21 - September 23
    3. Klenk Symposium 2017 – Tissue regeneration, wound healing and fibrosis: Translating basic concepts into regenerative therapy

      Oktober 15 - Oktober 17

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