Epidermal polarity genes in health and disease

Tellkamp F, Vorhagen S, Niessen CM Cold Spring Harb Perspect Med 2014 Dec;4(12):a015255 PMID: 25452423 Abstract The epidermis of the skin is a highly...   Read More

Mammalian aPKC/Par polarity complex mediated regulation of epithelial division orientation and cell fate

Vorhagen S, Niessen CM Exp. Cell Res. 2014 Nov;328(2):296-302 PMID: 25128813 Abstract Oriented cell division is a key regulator of tissue architecture and crucial...   Read More

Tropism-modified AAV vectors overcome barriers to successful cutaneous therapy

A1 NIESSENpublicationsSallach J, Di Pasquale G, Larcher F, Niehoff N, Rübsam M, Huber A, Chiorini J, Almarza D, Eming SA, Ulus H, Nishimura S, Hacker UT, Hallek M, Niessen CM, Büning H; Mol Ther. 2014 May;22(5):929-39. doi: 10.1038/mt.2014.14. Epub 2014 Jan 28.

Abstract Autologous human keratinocytes (HK) forming sheet grafts are approved as skin substitutes. Genetic engineering of HK represents a promising technique to improve engraftment...   Read More

aPKCλ controls epidermal homeostasis and stem cell fate through regulation of division orientation

A1 NIESSENpublicationsNiessen MT, Scott J, Zielinski JG, Vorhagen S, Sotiropoulou PA, Blanpain C, Leitges M, Niessen CM; J Cell Biol. 2013 Sep 16;202(6):887-900. doi: 10.1083/jcb.201307001. Epub 2013 Sep 9.

PMID: 24019538   Abstract The atypical protein kinase C (aPKC) is a key regulator of polarity and cell fate in lower organisms. However, whether...   Read More

Montagna Symposium 2012: Keeping it all together–adhesion, the cytoskeleton, and signaling in morphogenesis and tissue function

A1 NIESSENA5 BRÜNING/NIESSENpublicationsGreen KJ, Niessen CM, Godsel LM, Kulesz-Martin MF; J Invest Dermatol. 2013 May;133(5):1124-8. doi: 10.1038/jid.2013.59.


Analysis of bulge stem cells from the epidermis using flow cytometry

Villani RM, Akyuz MD, Niessen MT, Niessen CM Methods Mol. Biol. 2013;989:33-43 PMID: 23483385 Abstract The epidermis is a multilayered epithelium consisting of multiple...   Read More

Cadherin-based intercellular adhesions organize epithelial cell-matrix traction forces

A1 NIESSENpublicationsMertz AF, Che Y, Banerjee S, Goldstein JM, Rosowski KA, Revilla SF, Niessen CM, Marchetti MC, Dufresne ER, Horsley V; Proc Natl Acad Sci U S A. 2013 Jan 15;110(3):842-7. doi: 10.1073/pnas.1217279110. Epub 2012 Dec 31.

Abstract Cell-cell and cell-matrix adhesions play essential roles in the function of tissues. There is growing evidence for the importance of cross talk between...   Read More

Experimental analysis of risk factors for ulcerative dermatitis in mice

A1 NIESSENA5 BRÜNING/NIESSENpublicationsNeuhaus, B., Niessen C.M., Mesaros A., Withers D.J., Krieg T. and Partridge L., Exp Dermatol. 2012 Sep;21(9):712-3. doi: 10.1111/j.1600-0625.2012.01558.x.

Abstract Ulcerative dermatitis (UD) is a severe inflammatory skin disorder with an unknown aetiology. Recently, insulin receptor substrate 1 KO mice were shown to...   Read More

The in vivo function of mammalian cell and tissue polarity regulators–how to shape and maintain the epidermal barrier

A1 NIESSENpublications Niessen MT, Iden S, Niessen CM, J Cell Sci. 2012 Aug 1;125(Pt 15):3501-10. Epub 2012 Aug 30.

Abstract The establishment and maintenance of cell and tissue polarity is crucial for a range of biological processes, such as oriented division, migration, adhesion...   Read More

Classical and desmosomal cadherins at a glance

A1 NIESSENpublications Saito M, Tucker DK, Kohlhorst D, Niessen CM, Kowalczyk AP, J Cell Sci. 2012 Jun 1;125(Pt 11):2547-52. doi: 10.1242/jcs.066654.


  • Upcoming Events

    1. SFB 829 Connector Meeting

      April 6 @ 3:00 pm - 5:30 pm
    2. International Investigative Dermatology 2018

      Mai 16 - Mai 18
    3. Women in Science and Society with Sarah Millar

      Juni 19 @ 1:30 pm - 6:00 pm
    4. SFB 829 Connector Meeting

      August 31 @ 3:00 pm - 5:30 pm
    5. International Symposium „Molecular Mechanisms regulating Skin Homeostasis“

      November 12 - November 14

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