Adherens junctions in Mammalian development, homeostasis and disease: lessons from mice

A1 NIESSENpublications Boggetti B, Niessen CM, Subcell Biochem. 2012;60:321-55. doi: 10.1007/978-94-007-4186-7_14.

Abstract Mice have proven to be a particularly powerful model to study molecular mechanisms of development and disease. The reason for this is the...   Read More

Cadherin-dependent differential cell adhesion in Xenopus causes cell sorting in vitro but not in the embryo

A1 NIESSENpublicationsNinomiya, H., David, R., Dam, E.W., Fagotto, F., Niessen, C.M. and Winklbauer, R., J Cell Sci. 2012 Apr 15;125(Pt 8):1877-83. doi: 10.1242/jcs.095315. Epub 2012 Feb 10.

Abstract Adhesion differences between cell populations are in principle a source of strong morphogenetic forces promoting cell sorting, boundary formation and tissue positioning, and...   Read More

Vascular endothelial insulin/IGF-1 signaling controls skin wound vascularization

A1 NIESSENA5 BRÜNING/NIESSENpublications Aghdam SY, Eming SA, Willenborg S, Neuhaus B, Niessen CM, Partridge L, Krieg T, Bruning JC, Biochem Biophys Res Commun. 2012 May 4;421(2):197-202. doi: 10.1016/j.bbrc.2012.03.134. Epub 2012 Apr 4.

Abstract Type 2 diabetes mellitus affects 6% of western populations and represents a major risk factor for the development of skin complications, of which...   Read More

TCF/Lef1-mediated control of lipid metabolism regulates skin barrier function

A1 NIESSENpublicationsFehrenschild, D., Galli, U., Breiden, B., Bloch, W., Schettina, P., Brodesser, S., Michels, C., Günschmann, C., Sandhoff, K., Niessen, C.M., and Niemann, C., J Invest Dermatol. 2012 Feb;132(2):337-45. doi: 10.1038/jid.2011.301. Epub 2011 Sep 22.

Abstract Defects in the function of the skin barrier are associated with a wide variety of skin diseases, many of which are not well...   Read More

CD44 regulates tight junction assembly and barier function (2011)

A1 NIESSENpublications Kirschner,, N, Haftek, M, Niessen, C.M., Behne, M.J., Furuse, M., Moll, I. and Brandner J.M. J. Invest. Derm 2011 Apr;131(4):932-43

Abstract Upon barrier disturbance, adult CD44 knockout (KO) mice show delayed recovery of epidermal barrier function. This correlates with the loss of apical polarization...   Read More

The disintegrin/metalloproteinase ADAM10 is essential for the Notch -mediated development and integrity of the epidermis (2011 )

A1 NIESSENpublications Weber, S., Niessen, M, Prox, J. , Luellmann-Rauch, ,Schmitz, A., Schwanbeck, R., Blobel, C.P., de Strooper, B., Niessen, C.M.+ and Saftig, P.+ Development 138(3):495-505.

Abstract The disintegrin and metalloproteinase Adam10 has been implicated in the regulation of key signaling pathways that determine skin morphogenesis and homeostasis. To address...   Read More

An adhesion independent, aPKC dependent function for cadherins in morphogenetic movements (2009)

A1 NIESSENpublications Seifert, K., Ibrahim H., Winklbauer R. and Niessen C.M. J. Cell Sci.122: 2514-23.

Abstract Cadherin shedding affects migration and occurs in development and cancer progression. By examining the in vivo biological function of the extracellular cadherin domain...   Read More

Cadherin mediated regulation of tight junctions in stratifying epithelia (2009)

A1 NIESSENpublications Michels, C., Yadranji, S. and Niessen C.M., N Y Acad Sci. 1165:163-8.

Abstract In recent years several seminal breakthroughs have revealed that tight junctions not only regulate barrier properties of simple epithelial cells but also play...   Read More

Classical cadherins regulate desmosome formation (2009)

A1 NIESSENpublications Michels, C., Buchta T., Bloch W., Krieg, T, and Niessen C.M. J. Invest. Derm. 129:2072-5


  • Upcoming Events

    1. SFB 829 Connector Meeting

      April 6 @ 3:00 pm - 5:30 pm
    2. International Investigative Dermatology 2018

      Mai 16 - Mai 18
    3. Women in Science and Society with Sarah Millar

      Juni 19 @ 1:30 pm - 6:00 pm
    4. SFB 829 Connector Meeting

      August 31 @ 3:00 pm - 5:30 pm
    5. International Symposium „Molecular Mechanisms regulating Skin Homeostasis“

      November 12 - November 14

© 2017 SFB 829