Abstract Autologous human keratinocytes (HK) forming sheet grafts are approved as skin substitutes. Genetic engineering of HK represents a promising technique to improve engraftment... Read More
PMID: 24019538 Abstract The atypical protein kinase C (aPKC) is a key regulator of polarity and cell fate in lower organisms. However, whether mammalian... Read More
Villani RM, Akyuz MD, Niessen MT, Niessen CM Methods Mol. Biol. 2013;989:33-43 PMID: 23483385 Abstract The epidermis is a multilayered epithelium consisting of multiple... Read More
Abstract Cell-cell and cell-matrix adhesions play essential roles in the function of tissues. There is growing evidence for the importance of cross talk between... Read More
Abstract Ulcerative dermatitis (UD) is a severe inflammatory skin disorder with an unknown aetiology. Recently, insulin receptor substrate 1 KO mice were shown to... Read More
Abstract The establishment and maintenance of cell and tissue polarity is crucial for a range of biological processes, such as oriented division, migration, adhesion... Read More
Abstract Mice have proven to be a particularly powerful model to study molecular mechanisms of development and disease. The reason for this is the... Read More
Abstract Adhesion differences between cell populations are in principle a source of strong morphogenetic forces promoting cell sorting, boundary formation and tissue positioning, and... Read More
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