Tropism-modified AAV vectors overcome barriers to successful cutaneous therapy

January 28, 2014A1 NIESSENSallach J, Di Pasquale G, Larcher F, Niehoff N, Rübsam M, Huber A, Chiorini J, Almarza D, Eming SA, Ulus H, Nishimura S, Hacker UT, Hallek M, Niessen CM, Büning H; Mol Ther. 2014 May;22(5):929-39. doi: 10.1038/mt.2014.14. Epub 2014 Jan 28.

Abstract Autologous human keratinocytes (HK) forming sheet grafts are approved as skin substitutes. Genetic engineering of HK represents a promising technique to improve engraftment... Read More

aPKCλ controls epidermal homeostasis and stem cell fate through regulation of division orientation

September 9, 2013A1 NIESSENNiessen MT, Scott J, Zielinski JG, Vorhagen S, Sotiropoulou PA, Blanpain C, Leitges M, Niessen CM; J Cell Biol. 2013 Sep 16;202(6):887-900. doi: 10.1083/jcb.201307001. Epub 2013 Sep 9.

PMID: 24019538 Abstract The atypical protein kinase C (aPKC) is a key regulator of polarity and cell fate in lower organisms. However, whether mammalian... Read More

Montagna Symposium 2012: Keeping it all together–adhesion, the cytoskeleton, and signaling in morphogenesis and tissue function

May 1, 2013A1 NIESSEN A5 BRÜNING/NIESSENGreen KJ, Niessen CM, Godsel LM, Kulesz-Martin MF; J Invest Dermatol. 2013 May;133(5):1124-8. doi: 10.1038/jid.2013.59.

Pubmed

Analysis of bulge stem cells from the epidermis using flow cytometry

March 13, 2013A1 NIESSEN

Villani RM, Akyuz MD, Niessen MT, Niessen CM Methods Mol. Biol. 2013;989:33-43 PMID: 23483385 Abstract The epidermis is a multilayered epithelium consisting of multiple... Read More

Cadherin-based intercellular adhesions organize epithelial cell-matrix traction forces

January 15, 2013A1 NIESSENMertz AF, Che Y, Banerjee S, Goldstein JM, Rosowski KA, Revilla SF, Niessen CM, Marchetti MC, Dufresne ER, Horsley V; Proc Natl Acad Sci U S A. 2013 Jan 15;110(3):842-7. doi: 10.1073/pnas.1217279110. Epub 2012 Dec 31.

Abstract Cell-cell and cell-matrix adhesions play essential roles in the function of tissues. There is growing evidence for the importance of cross talk between... Read More

Experimental analysis of risk factors for ulcerative dermatitis in mice

September 15, 2012A1 NIESSEN A5 BRÜNING/NIESSENNeuhaus, B., Niessen C.M., Mesaros A., Withers D.J., Krieg T. and Partridge L., Exp Dermatol. 2012 Sep;21(9):712-3. doi: 10.1111/j.1600-0625.2012.01558.x.

Abstract Ulcerative dermatitis (UD) is a severe inflammatory skin disorder with an unknown aetiology. Recently, insulin receptor substrate 1 KO mice were shown to... Read More

The in vivo function of mammalian cell and tissue polarity regulators–how to shape and maintain the epidermal barrier

August 1, 2012A1 NIESSEN Niessen MT, Iden S, Niessen CM, J Cell Sci. 2012 Aug 1;125(Pt 15):3501-10. Epub 2012 Aug 30.

Abstract The establishment and maintenance of cell and tissue polarity is crucial for a range of biological processes, such as oriented division, migration, adhesion... Read More

Classical and desmosomal cadherins at a glance

June 1, 2012A1 NIESSEN Saito M, Tucker DK, Kohlhorst D, Niessen CM, Kowalczyk AP, J Cell Sci. 2012 Jun 1;125(Pt 11):2547-52. doi: 10.1242/jcs.066654.

Pubmed

Adherens junctions in Mammalian development, homeostasis and disease: lessons from mice

June 1, 2012A1 NIESSEN Boggetti B, Niessen CM, Subcell Biochem. 2012;60:321-55. doi: 10.1007/978-94-007-4186-7_14.

Abstract Mice have proven to be a particularly powerful model to study molecular mechanisms of development and disease. The reason for this is the... Read More

Cadherin-dependent differential cell adhesion in Xenopus causes cell sorting in vitro but not in the embryo

April 10, 2012A1 NIESSENNinomiya, H., David, R., Dam, E.W., Fagotto, F., Niessen, C.M. and Winklbauer, R., J Cell Sci. 2012 Apr 15;125(Pt 8):1877-83. doi: 10.1242/jcs.095315. Epub 2012 Feb 10.

Abstract Adhesion differences between cell populations are in principle a source of strong morphogenetic forces promoting cell sorting, boundary formation and tissue positioning, and... Read More

A1 NIESSEN