Vascular endothelial insulin/IGF-1 signaling controls skin wound vascularization

April 4, 2012A1 NIESSEN A5 BRÜNING/NIESSEN Aghdam SY, Eming SA, Willenborg S, Neuhaus B, Niessen CM, Partridge L, Krieg T, Bruning JC, Biochem Biophys Res Commun. 2012 May 4;421(2):197-202. doi: 10.1016/j.bbrc.2012.03.134. Epub 2012 Apr 4.

Abstract Type 2 diabetes mellitus affects 6% of western populations and represents a major risk factor for the development of skin complications, of which... Read More

TCF/Lef1-mediated control of lipid metabolism regulates skin barrier function

February 1, 2012A1 NIESSENFehrenschild, D., Galli, U., Breiden, B., Bloch, W., Schettina, P., Brodesser, S., Michels, C., Günschmann, C., Sandhoff, K., Niessen, C.M., and Niemann, C., J Invest Dermatol. 2012 Feb;132(2):337-45. doi: 10.1038/jid.2011.301. Epub 2011 Sep 22.

Abstract Defects in the function of the skin barrier are associated with a wide variety of skin diseases, many of which are not well... Read More

CD44 regulates tight junction assembly and barier function (2011)

August 3, 2011A1 NIESSEN Kirschner,, N, Haftek, M, Niessen, C.M., Behne, M.J., Furuse, M., Moll, I. and Brandner J.M. J. Invest. Derm 2011 Apr;131(4):932-43

Abstract Upon barrier disturbance, adult CD44 knockout (KO) mice show delayed recovery of epidermal barrier function. This correlates with the loss of apical polarization... Read More

The disintegrin/metalloproteinase ADAM10 is essential for the Notch -mediated development and integrity of the epidermis (2011 )

August 3, 2011A1 NIESSEN Weber, S., Niessen, M, Prox, J. , Luellmann-Rauch, ,Schmitz, A., Schwanbeck, R., Blobel, C.P., de Strooper, B., Niessen, C.M.+ and Saftig, P.+ Development 138(3):495-505.

Abstract The disintegrin and metalloproteinase Adam10 has been implicated in the regulation of key signaling pathways that determine skin morphogenesis and homeostasis. To address... Read More

An adhesion independent, aPKC dependent function for cadherins in morphogenetic movements (2009)

August 3, 2011A1 NIESSEN Seifert, K., Ibrahim H., Winklbauer R. and Niessen C.M. J. Cell Sci.122: 2514-23.

Abstract Cadherin shedding affects migration and occurs in development and cancer progression. By examining the in vivo biological function of the extracellular cadherin domain... Read More

Cadherin mediated regulation of tight junctions in stratifying epithelia (2009)

August 3, 2011A1 NIESSEN Michels, C., Yadranji, S. and Niessen C.M., N Y Acad Sci. 1165:163-8.

Abstract In recent years several seminal breakthroughs have revealed that tight junctions not only regulate barrier properties of simple epithelial cells but also play... Read More

Classical cadherins regulate desmosome formation (2009)

August 3, 2011A1 NIESSEN Michels, C., Buchta T., Bloch W., Krieg, T, and Niessen C.M. J. Invest. Derm. 129:2072-5

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