Abstract Type 2 diabetes mellitus affects 6% of western populations and represents a major risk factor for the development of skin complications, of which... Read More
Abstract Defects in the function of the skin barrier are associated with a wide variety of skin diseases, many of which are not well... Read More
Abstract Upon barrier disturbance, adult CD44 knockout (KO) mice show delayed recovery of epidermal barrier function. This correlates with the loss of apical polarization... Read More
Abstract The disintegrin and metalloproteinase Adam10 has been implicated in the regulation of key signaling pathways that determine skin morphogenesis and homeostasis. To address... Read More
Abstract Cadherin shedding affects migration and occurs in development and cancer progression. By examining the in vivo biological function of the extracellular cadherin domain... Read More
Abstract In recent years several seminal breakthroughs have revealed that tight junctions not only regulate barrier properties of simple epithelial cells but also play... Read More
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