A10 IDEN

The epidermal polarity protein Par3 is a non-cell autonomous suppressor of malignant melanoma

Mescher M, Jeong P, Knapp SK, Rübsam M, Saynisch M, Kranen M, Landsberg J, Schlaak M, Mauch C, Tüting T, Niessen CM, Iden S...   Read More

Epithelial barriers in murine skin during herpes simplex virus 1 infection: The role of tight junction formation

Rahn E, Thier K, Petermann P, Rübsam M, Staeheli P, Iden S, Niessen CM, Knebel-Mörsdorf D J. Invest. Dermatol. 2016 Dec; PMID: 27939379 Abstract...   Read More

mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation

Ding X, Bloch W, Iden S, Rüegg MA, Hall MN, Leptin M, Partridge L, Eming SA Nat Commun 2016 Oct;7:13226 PMID: 27807348 Abstract Mammalian...   Read More

Essential role of polarity protein Par3 for epidermal homeostasis through regulation of barrier function, keratinocyte differentiation and stem cell maintenance

Ali NJ, Dias Gomes M, Bauer R, Brodesser S, Niemann C, Iden S J. Invest. Dermatol. 2016 Jul; PMID: 27452221 Abstract Partitioning-defective (Par) proteins...   Read More

A Novel Model of Metastatic Conjunctival Melanoma in Immune-Competent Mice

A10 IDENpublicationsSchlereth SL, Iden S, Mescher M, Ksander BR, Bosch JJ, Cursiefen C, Heindl LM; Invest Ophthalmol Vis Sci. 2015 Sep;56(10):5965-73. doi: 10.1167/iovs.15-17290.

Abstract PURPOSE: Conjunctival melanoma (CM) is an ocular surface tumor that can lead to fatal metastases. Patients developing, tumor-associated lymphangiogenesis have a significantly increased...   Read More

JAM-A regulates cortical dynein localization through Cdc42 to control planar spindle orientation during mitosis

A10 IDENpublicationsTuncay H, Brinkmann BF, Steinbacher T, Schürmann A, Gerke V, Iden S, Ebnet K; Nat Commun. 2015 Aug 26;6:8128. doi: 10.1038/ncomms9128.

Abstract Planar spindle orientation in polarized epithelial cells depends on the precise localization of the dynein-dynactin motor protein complex at the lateral cortex. The...   Read More

Comparing the Hem- and Lymphangiogenic Profile of Conjunctival and Uveal Melanoma Cell Lines

A10 IDENpublicationsRefaian N, Schlereth SL, Koch KR, Notara M, Hos D, Mescher M, Iden S, Bosch JJ, Jager MJ, Cursiefen C, Heindl LM; Invest Ophthalmol Vis Sci. 2015 Aug;56(9):5691-7. doi: 10.1167/iovs.15-16829.

Abstract PURPOSE: Malignant melanomas of the ocular surface (conjunctival melanoma [CM]) and within the eye (uveal melanoma [UM]) show different types of metastatic behavior....   Read More

Par Proteins in Tumor Formation and Progression

Mescher, M., and Iden, S. (2015). Cell Polarity 2. Role in Dev. and Dis. Springer 2, 344. Book chapter.

Impact of the Prolymphangiogenic Crosstalk in the Tumor Microenvironment on Lymphatic Cancer Metastasis

A10 IDENpublicationsSchlereth S, Refaian N, Iden S, Cursiefen C, Heindl; BioMed Research International. 2014:639058. Epub 2014 Sep 1

Abstract Lymphangiogenesis is a very early step in lymphatic metastasis. It is regulated and promoted not only by the tumor cells themselves, but also...   Read More

Function of mammalian cell polarity regulators in skin cancer

A10 IDENpublicationsMescher M, Iden S; Cell News 4/14.

Abstract Establishment of cell polarity and orchestrated tissue architecture are critical to development, organ homeostasis and regeneration. Almost every cell type in our body...   Read More

  • Upcoming Events

    1. 4th PhD student and Postdoc Minisymposium

      Juli 7 @ 3:00 pm - 5:00 pm
    2. 4th German-French DNA Repair Meeting Cologne 2017

      September 21 - September 23
    3. 33. Klenk Symposium 2017 in Molecular Medicine

      Oktober 15 - Oktober 17

© 2017 SFB 829