A10 IDEN

Polarity signaling ensures epidermal homeostasis by coupling cellular mechanics and genomic integrity

Dias Gomes M, Letzian S, Saynisch M, Iden S Nat Commun 2019 Jul;10(1):3362 PMID: 31358743 Abstract Epithelial homeostasis requires balanced progenitor cell proliferation and...   Read More

Shared and independent functions of aPKCλ and Par3 in skin tumorigenesis

Vorhagen S, Kleefisch D, Persa OD, Graband A, Schwickert A, Saynisch M, Leitges M, Niessen CM, Iden S Oncogene 2018 09;37(37):5136-5146 PMID: 29789715 Abstract...   Read More

The epidermal polarity protein Par3 is a non-cell autonomous suppressor of malignant melanoma

Mescher M, Jeong P, Knapp SK, Rübsam M, Saynisch M, Kranen M, Landsberg J, Schlaak M, Mauch C, Tüting T, Niessen CM, Iden S...   Read More

Epithelial barriers in murine skin during herpes simplex virus 1 infection: The role of tight junction formation

Rahn E, Thier K, Petermann P, Rübsam M, Staeheli P, Iden S, Niessen CM, Knebel-Mörsdorf D J. Invest. Dermatol. 2016 Dec; PMID: 27939379 Abstract...   Read More

mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation

Ding X, Bloch W, Iden S, Rüegg MA, Hall MN, Leptin M, Partridge L, Eming SA Nat Commun 2016 Oct;7:13226 PMID: 27807348 Abstract Mammalian...   Read More

Essential role of polarity protein Par3 for epidermal homeostasis through regulation of barrier function, keratinocyte differentiation and stem cell maintenance

Ali NJ, Dias Gomes M, Bauer R, Brodesser S, Niemann C, Iden S J. Invest. Dermatol. 2016 Jul; PMID: 27452221 Abstract Partitioning-defective (Par) proteins...   Read More

A Novel Model of Metastatic Conjunctival Melanoma in Immune-Competent Mice

A10 IDENSchlereth SL, Iden S, Mescher M, Ksander BR, Bosch JJ, Cursiefen C, Heindl LM; Invest Ophthalmol Vis Sci. 2015 Sep;56(10):5965-73. doi: 10.1167/iovs.15-17290.

Abstract PURPOSE: Conjunctival melanoma (CM) is an ocular surface tumor that can lead to fatal metastases. Patients developing, tumor-associated lymphangiogenesis have a significantly increased...   Read More

JAM-A regulates cortical dynein localization through Cdc42 to control planar spindle orientation during mitosis

A10 IDENTuncay H, Brinkmann BF, Steinbacher T, Schürmann A, Gerke V, Iden S, Ebnet K; Nat Commun. 2015 Aug 26;6:8128. doi: 10.1038/ncomms9128.

Abstract Planar spindle orientation in polarized epithelial cells depends on the precise localization of the dynein-dynactin motor protein complex at the lateral cortex. The...   Read More

Comparing the Hem- and Lymphangiogenic Profile of Conjunctival and Uveal Melanoma Cell Lines

A10 IDENRefaian N, Schlereth SL, Koch KR, Notara M, Hos D, Mescher M, Iden S, Bosch JJ, Jager MJ, Cursiefen C, Heindl LM; Invest Ophthalmol Vis Sci. 2015 Aug;56(9):5691-7. doi: 10.1167/iovs.15-16829.

Abstract PURPOSE: Malignant melanomas of the ocular surface (conjunctival melanoma [CM]) and within the eye (uveal melanoma [UM]) show different types of metastatic behavior....   Read More

Par Proteins in Tumor Formation and Progression

Mescher, M., and Iden, S. (2015). Cell Polarity 2. Role in Dev. and Dis. Springer 2, 344. Book chapter.

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