A10 IDEN

The in vivo function of mammalian cell and tissue polarity regulators: how to shape and maintain the epidermal barrier

A10 IDENpublications Niessen, M.T., Iden, S., Niessen, C.M., J Cell Sci. 2012 Aug 1;125(Pt 15):3501-10. Epub 2012 Aug 30

Abstract   The establishment and maintenance of cell and tissue polarity is crucial for a range of biological processes, such as oriented division, migration,...   Read More

A Mutation in the 5?-UTR of IFITM5 Creates an In-Frame Start Codon and Causes Autosomal-Dominant Osteogenesis Imperfecta Type V with Hyperplastic Callus

A10 IDENpublicationsSemler O, Garbes L, Keupp K, Swan D, Zimmermann K, Becker J, Iden S, Wirth B, Eysel P, Koerber F, Schoenau E, Bohlander SK, Wollnik B, Netzer C; The American Journal of Human Genetics 2012 Aug; 10;91(2):349-57. doi: 10.1016/j.ajhg.2012.06.011. Epub 2012 Aug 2.

Abstract Osteogenesis imperfecta (OI) is a clinically and genetically heterogeneous disorder associated with bone fragility and susceptibility to fractures after minimal trauma. OI type...   Read More

Tumor type-dependent function of the par3 polarity protein in skin tumorigenesis

A10 IDENpublications Iden S., van Riel WE, Schäfer R, Song JY, Hirose T, Ohno S, Collard JG; Cancer Cell. 2012 Sep 11;22(3):389-403. doi: 10.1016/j.ccr.2012.08.004.

Abstract   Cell polarization is crucial during development and tissue homeostasis and is regulated by conserved proteins of the Scribble, Crumbs, and Par complexes....   Read More

Cell polarity proteins and cancer

A10 IDENpublicationsEllenbroek, S.I.J., Iden, S., Collard, J.G., Semin Cancer Biol. 2012 Jun;22(3):208-15. doi: 10.1016/j.semcancer.2012.02.012. Epub 2012 Mar 23.

Abstract   Cell polarity is essential in many biological processes and required for development as well as maintenance of tissue integrity. Loss of polarity...   Read More

aPKC phosphorylates JAM-A at Ser285 to promote cell contact maturation and tight junction formation

A10 IDENpublicationsIden, S., Misselwitz, S., Peddibhotla, S., Tuncay, H., Rehder, D., Gerke, V., Robenek, H., Suzuki, A., Ebnet, K., J Cell Biol. 2012 Mar 5;196(5):623-39. doi: 10.1083/jcb.201104143. Epub 2012 Feb 27

Abstract   The PAR-3-atypical protein kinase C (aPKC)-PAR-6 complex has been implicated in the development of apicobasal polarity and the formation of tight junctions...   Read More

The Rac activator Tiam1 is required for polarized protrusional outgrowth of primary astrocytes by affecting the organization of the microtubule network

A10 IDENpublicationsEllenbroek, S.I.J., Iden, S., Collard, J.G., Small GTPases. 2012 Jan-Mar;3(1):4-14. doi: 10.4161/sgtp.19379. Epub 2012 Jan 1

Abstract   Polarized cell migration is a crucial process in the development and repair of tissues, as well as in pathological conditions, including cancer....   Read More

Crosstalk between small GTPases and polarity proteins in cell polarization

A10 IDENpublicationsIden, S., Collard, J.G. (2008), Nat. Rev. Mol. Cell Biol.11, 846-59.

Abstract Cell polarization is crucial for the development of multicellular organisms, and aberrant cell polarization contributes to various diseases, including cancer. How cell polarity...   Read More

JAM-C regulates tight junctions and integrin-mediated cell adhesion and migration

A10 IDENpublicationsMandicourt, G., Iden, S., Ebnet, K., Aurrand-Lions, M., Imhof, B.A., J Biol Chem. 2007 Jan 19;282(3):1830-7. Epub 2006 Nov 12.

Abstract   Junctional Adhesion Molecules (JAMs) have been described as major components of tight junctions in endothelial and epithelial cells. Tight junctions are crucial...   Read More

A distinct PAR complex associates physically with VE-cadherin in vertebrate endothelial cells (2006)

A10 IDENpublicationsIden, S., Rehder, D., August, B., Suzuki, A., Noda, K., Nagafuchi, A., Wolburg-Buchholz, K., Wolburg, H., Ohno, S., Behrens, J., Vestweber, D., Ebnet, K., EMBO Rep. 2006 Dec;7(12):1239-46. Epub 2006 Oct 20.

Abstract A cell polarity complex consisting of partitioning defective 3 (PAR-3), atypical protein kinase C (aPKC) and PAR-6 has a central role in the...   Read More

Junctional adhesion molecule-a participates in the formation of apico-basal polarity through different domains

A10 IDENpublicationsRehder, D., Iden, S., Nasdala, I., Wegener, J., Brickwedde, M.K., Vestweber, D., Ebnet, K., Exp Cell Res. 2006 Oct 15;312(17):3389-403. Epub 2006 Jul 21

Abstract   Junctional adhesion molecule (JAM)-A is an integral membrane protein at tight junctions of epithelial cells which associates with the cell polarity protein...   Read More

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