A10 IDEN

Impact of the Prolymphangiogenic Crosstalk in the Tumor Microenvironment on Lymphatic Cancer Metastasis

A10 IDENSchlereth S, Refaian N, Iden S, Cursiefen C, Heindl; BioMed Research International. 2014:639058. Epub 2014 Sep 1

Abstract Lymphangiogenesis is a very early step in lymphatic metastasis. It is regulated and promoted not only by the tumor cells themselves, but also...   Read More

Function of mammalian cell polarity regulators in skin cancer

A10 IDENMescher M, Iden S; Cell News 4/14.

Abstract Establishment of cell polarity and orchestrated tissue architecture are critical to development, organ homeostasis and regeneration. Almost every cell type in our body...   Read More

The in vivo function of mammalian cell and tissue polarity regulators: how to shape and maintain the epidermal barrier

A10 IDEN Niessen, M.T., Iden, S., Niessen, C.M., J Cell Sci. 2012 Aug 1;125(Pt 15):3501-10. Epub 2012 Aug 30

Abstract   The establishment and maintenance of cell and tissue polarity is crucial for a range of biological processes, such as oriented division, migration,...   Read More

A Mutation in the 5?-UTR of IFITM5 Creates an In-Frame Start Codon and Causes Autosomal-Dominant Osteogenesis Imperfecta Type V with Hyperplastic Callus

A10 IDENSemler O, Garbes L, Keupp K, Swan D, Zimmermann K, Becker J, Iden S, Wirth B, Eysel P, Koerber F, Schoenau E, Bohlander SK, Wollnik B, Netzer C; The American Journal of Human Genetics 2012 Aug; 10;91(2):349-57. doi: 10.1016/j.ajhg.2012.06.011. Epub 2012 Aug 2.

Abstract Osteogenesis imperfecta (OI) is a clinically and genetically heterogeneous disorder associated with bone fragility and susceptibility to fractures after minimal trauma. OI type...   Read More

Tumor type-dependent function of the par3 polarity protein in skin tumorigenesis

A10 IDEN Iden S., van Riel WE, Schäfer R, Song JY, Hirose T, Ohno S, Collard JG; Cancer Cell. 2012 Sep 11;22(3):389-403. doi: 10.1016/j.ccr.2012.08.004.

Abstract   Cell polarization is crucial during development and tissue homeostasis and is regulated by conserved proteins of the Scribble, Crumbs, and Par complexes....   Read More

Cell polarity proteins and cancer

A10 IDENEllenbroek, S.I.J., Iden, S., Collard, J.G., Semin Cancer Biol. 2012 Jun;22(3):208-15. doi: 10.1016/j.semcancer.2012.02.012. Epub 2012 Mar 23.

Abstract   Cell polarity is essential in many biological processes and required for development as well as maintenance of tissue integrity. Loss of polarity...   Read More

aPKC phosphorylates JAM-A at Ser285 to promote cell contact maturation and tight junction formation

A10 IDENIden, S., Misselwitz, S., Peddibhotla, S., Tuncay, H., Rehder, D., Gerke, V., Robenek, H., Suzuki, A., Ebnet, K., J Cell Biol. 2012 Mar 5;196(5):623-39. doi: 10.1083/jcb.201104143. Epub 2012 Feb 27

Abstract   The PAR-3-atypical protein kinase C (aPKC)-PAR-6 complex has been implicated in the development of apicobasal polarity and the formation of tight junctions...   Read More

The Rac activator Tiam1 is required for polarized protrusional outgrowth of primary astrocytes by affecting the organization of the microtubule network

A10 IDENEllenbroek, S.I.J., Iden, S., Collard, J.G., Small GTPases. 2012 Jan-Mar;3(1):4-14. doi: 10.4161/sgtp.19379. Epub 2012 Jan 1

Abstract   Polarized cell migration is a crucial process in the development and repair of tissues, as well as in pathological conditions, including cancer....   Read More

Crosstalk between small GTPases and polarity proteins in cell polarization

A10 IDENIden, S., Collard, J.G. (2008), Nat. Rev. Mol. Cell Biol.11, 846-59.

Abstract Cell polarization is crucial for the development of multicellular organisms, and aberrant cell polarization contributes to various diseases, including cancer. How cell polarity...   Read More

JAM-C regulates tight junctions and integrin-mediated cell adhesion and migration

A10 IDENMandicourt, G., Iden, S., Ebnet, K., Aurrand-Lions, M., Imhof, B.A., J Biol Chem. 2007 Jan 19;282(3):1830-7. Epub 2006 Nov 12.

Abstract   Junctional Adhesion Molecules (JAMs) have been described as major components of tight junctions in endothelial and epithelial cells. Tight junctions are crucial...   Read More

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