The promotion of endothelial cell attachment and spreading using FNIII10 fused to VEGF-A165

A11 WICKSTRÖMpublicationsTraub S, Morgner J, Martino MM, Höning S, Swartz MA, Wickström SA, Hubbell JA, Eming SA; Biomaterials. 2013 Aug;34(24):5958-68. doi: 10.1016/j.biomaterials.2013.04.050. Epub 2013 May 14.

Abstract   Synergy in the downstream signaling pathways of the vascular endothelial growth factor receptor-2 (VEGFR-2) and the integrin αvβ3 is critical for blood...   Read More

ILK: a pseudokinase with a unique function in the integrin-actin linkage

Ghatak S, Morgner J, Wickström SA Biochem. Soc. Trans. 2013 Aug;41(4):995-1001 PMID: 23863169 Abstract ILK (integrin-linked kinase) is a central component of cell-matrix adhesions...   Read More

Stabilization of integrin-linked kinase by the Hsp90-CHIP axis impacts cellular force generation, migration and the fibrotic response

A11 WICKSTRÖMB3 ECKES KRIEGpublications Radovanac K, Morgner J, Schulz JN, Blumbach K, Patterson C, Geiger T, Mann M, Krieg T, Eckes B, Fässler R, Wickström SA; EMBO J. 2013 May 15;32(10):1409-24. doi: 10.1038/emboj.2013.90. Epub 2013 Apr 23.

Abstract   Integrin-linked kinase (ILK) is an adaptor protein required to establish and maintain the connection between integrins and the actin cytoskeleton. This linkage...   Read More

Genetic analyses of integrin signaling

A11 WICKSTRÖMpublicationsWickström, S., Radovanac, K., Fässler, R., Cold Spring Harb Perspect Biol. 2011 Feb 1;3(2). pii: a005116. doi: 10.1101/cshperspect.a005116

Abstract   The development of multicellular organisms, as well as maintenance of organ architecture and function, requires robust regulation of cell fates. This is...   Read More

Integrin-linked kinase controls microtubule dynamics required for plasma membrane targeting of caveolae

A11 WICKSTRÖMpublicationsWickström, S.A.*, Lange, A., Hess, M.J. Polleux, J., Spatz, J.P., Krüger, M., Pfaller, K., Lambacher, A., Bloch, W., Mann, M., Huber, L.A., and Fässler, R., Dev Cell. 2010 Oct 19;19(4):574-88. doi: 10.1016/j.devcel.2010.09.007.

Abstract Caveolae are specialized compartments of the plasma membrane that are involved in signaling, endocytosis, and cholesterol transport. Their formation requires the transport of...   Read More

The ILK/PINCH/parvin complex: the kinase is dead, long live the pseudokinase!

A11 WICKSTRÖMpublicationsWickström, S.A., Lange, A., Montanez, E., and Fässler, R., EMBO J. 2010 Jan 20;29(2):281-91. doi: 10.1038/emboj.2009.376. Epub 2009 Dec 24.

Abstract   Dynamic interactions of cells with their environment regulate multiple aspects of tissue morphogenesis and function. Integrins are the major class of cell...   Read More

CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin

A11 WICKSTRÖMpublicationsWickström, S.A., Masoumi, K.C., Khochbin, S., Fässler, R., and Massoumi, R., EMBO J. 2010 Jan 6;29(1):131-44. doi: 10.1038/emboj.2009.317. Epub 2009 Nov 5.

Abstract CYLD is a tumour-suppressor gene that is mutated in a benign skin tumour syndrome called cylindromatosis. The CYLD gene product is a deubiquitinating...   Read More

Alpha-parvin controls vascular mural cell recruitment to vessel wall by regulating RhoA/ROCK signalling

A11 WICKSTRÖMpublicationsMontanez, E., Wickström, S.A., Altstätter, J., Chu, H., and Fässler, R., EMBO J. 2009 Oct 21;28(20):3132-44. doi: 10.1038/emboj.2009.295. Epub 2009 Oct 1

Abstract During blood vessel development, vascular smooth muscle cells (vSMCs) and pericytes (PCs) are recruited to nascent vessels to stabilize them and to guide...   Read More

Integrin-linked kinase is an adaptor with essential functions during mouse development

A11 WICKSTRÖMpublicationsLange, A., Wickström S.A., Jakobson, M., Zent, R., Sainio, K., and Fässler, R., Nature. 2009 Oct 15;461(7266):1002-6. doi: 10.1038/nature08468.

Abstract The development of multicellular organisms requires integrin-mediated interactions between cells and their extracellular environment. Integrin binding to extracellular matrix catalyses assembly of multiprotein...   Read More

Genetic and cell biological analysis of integrin outside-in signaling

A11 WICKSTRÖMpublicationsLegate, K.R., Wickström, S.A., Fässler, R., Genes Dev. 2009 Feb 15;23(4):397-418. doi: 10.1101/gad.1758709.

Abstract Integrins are cell surface transmembrane receptors that recognize and bind to extracellular matrix proteins and counter receptors. Binding of activated integrins to their...   Read More

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