Integrin-linked kinase controls microtubule dynamics required for plasma membrane targeting of caveolae

A11 WICKSTRÖMpublicationsWickström, S.A.*, Lange, A., Hess, M.J. Polleux, J., Spatz, J.P., Krüger, M., Pfaller, K., Lambacher, A., Bloch, W., Mann, M., Huber, L.A., and Fässler, R., Dev Cell. 2010 Oct 19;19(4):574-88. doi: 10.1016/j.devcel.2010.09.007.

Abstract Caveolae are specialized compartments of the plasma membrane that are involved in signaling, endocytosis, and cholesterol transport. Their formation requires the transport of...   Read More

The ILK/PINCH/parvin complex: the kinase is dead, long live the pseudokinase!

A11 WICKSTRÖMpublicationsWickström, S.A., Lange, A., Montanez, E., and Fässler, R., EMBO J. 2010 Jan 20;29(2):281-91. doi: 10.1038/emboj.2009.376. Epub 2009 Dec 24.

Abstract   Dynamic interactions of cells with their environment regulate multiple aspects of tissue morphogenesis and function. Integrins are the major class of cell...   Read More

CYLD negatively regulates cell-cycle progression by inactivating HDAC6 and increasing the levels of acetylated tubulin

A11 WICKSTRÖMpublicationsWickström, S.A., Masoumi, K.C., Khochbin, S., Fässler, R., and Massoumi, R., EMBO J. 2010 Jan 6;29(1):131-44. doi: 10.1038/emboj.2009.317. Epub 2009 Nov 5.

Abstract CYLD is a tumour-suppressor gene that is mutated in a benign skin tumour syndrome called cylindromatosis. The CYLD gene product is a deubiquitinating...   Read More

Alpha-parvin controls vascular mural cell recruitment to vessel wall by regulating RhoA/ROCK signalling

A11 WICKSTRÖMpublicationsMontanez, E., Wickström, S.A., Altstätter, J., Chu, H., and Fässler, R., EMBO J. 2009 Oct 21;28(20):3132-44. doi: 10.1038/emboj.2009.295. Epub 2009 Oct 1

Abstract During blood vessel development, vascular smooth muscle cells (vSMCs) and pericytes (PCs) are recruited to nascent vessels to stabilize them and to guide...   Read More

Integrin-linked kinase is an adaptor with essential functions during mouse development

A11 WICKSTRÖMpublicationsLange, A., Wickström S.A., Jakobson, M., Zent, R., Sainio, K., and Fässler, R., Nature. 2009 Oct 15;461(7266):1002-6. doi: 10.1038/nature08468.

Abstract The development of multicellular organisms requires integrin-mediated interactions between cells and their extracellular environment. Integrin binding to extracellular matrix catalyses assembly of multiprotein...   Read More

Genetic and cell biological analysis of integrin outside-in signaling

A11 WICKSTRÖMpublicationsLegate, K.R., Wickström, S.A., Fässler, R., Genes Dev. 2009 Feb 15;23(4):397-418. doi: 10.1101/gad.1758709.

Abstract Integrins are cell surface transmembrane receptors that recognize and bind to extracellular matrix proteins and counter receptors. Binding of activated integrins to their...   Read More

Integrin-linked kinase stabilizes myotendinous junctions and protects muscle from stress-induced damage

A11 WICKSTRÖMpublicationsWang, H.V., Chang, L.W., Brixius, K., Wickström, S.A, Montanez, E., Thievessen, I., Schwander, M., Müller, U., Bloch, W., Mayer, U., Fässler, R., J Cell Biol. 2008 Mar 10;180(5):1037-49. doi: 10.1083/jcb.200707175

Abstract Skeletal muscle expresses high levels of integrin-linked kinase (ILK), predominantly at myotendinous junctions (MTJs) and costameres. ILK binds the cytoplasmic domain of beta1...   Read More

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