Foxd3 Promotes Exit from Naive Pluripotency through Enhancer Decommissioning and Inhibits Germline Specification

Respuela P, Nikolić M, Tan M, Frommolt P, Zhao Y, Wysocka J, Rada-Iglesias A Cell Stem Cell 2016 Jan;18(1):118-33 PMID: 26748758 Abstract Following implantation,...   Read More

Genetic variation within transcriptional regulatory elements and its implications for human disease

Rada-Iglesias A Biol. Chem. 2014 Dec;395(12):1453-60 PMID: 25205712 Abstract Common human pathologies have a complicated etiology involving both genetic and environmental risk factors. Moreover,...   Read More

Epigenomic annotation of enhancers predicts transcriptional regulators of human neural crest

Rada-Iglesias A, Bajpai R, Prescott S, Brugmann SA, Swigut T, Wysocka J Cell Stem Cell 2012 Nov;11(5):633-48 PMID: 22981823 Abstract Neural crest cells (NCC)...   Read More

Epigenomics of human embryonic stem cells and induced pluripotent stem cells: insights into pluripotency and implications for disease

Rada-Iglesias A, Wysocka J Genome Med 2011 Jun;3(6):36 PMID: 21658297 Abstract Human pluripotent cells such as human embryonic stem cells (hESCs) and induced pluripotent...   Read More

A unique chromatin signature uncovers early developmental enhancers in humans

Rada-Iglesias A, Bajpai R, Swigut T, Brugmann SA, Flynn RA, Wysocka J Nature 2011 Feb;470(7333):279-83 PMID: 21160473 Abstract Cell-fate transitions involve the integration of...   Read More

  • Upcoming Events

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