A13 RADA-IGLESIAS

Mechanism suppressing H3K9 trimethylation in pluripotent stem cells and its demise by polyQ-expanded huntingtin mutations

Irmak D, Fatima A, Gutiérrez-Garcia R, Rinschen MM, Wagle P, Altmüller J, Arrigoni L, Hummel B, Klein C, Frese CK, Sawarkar R, Rada-Iglesias A,...   Read More

Pioneering of Enhancer Landscapes during Pluripotent State Transitions

Rada-Iglesias A Cell Stem Cell 2018 Aug;23(2):149-151 PMID: 30075122 Abstract The transitions between different pluripotency states are regulated by large changes in enhancer landscapes....   Read More

Lineage specific transcription factors and epigenetic regulators mediate TGFβ-dependent enhancer activation

Fueyo R, Iacobucci S, Pappa S, Estarás C, Lois S, Vicioso-Mantis M, Navarro C, Cruz-Molina S, Reyes JC, Rada-Iglesias Á, de la Cruz X,...   Read More

Is H3K4me1 at enhancers correlative or causative?

Rada-Iglesias A Nat. Genet. 2018 Jan;50(1):4-5 PMID: 29273804 Abstract

Ready, Set…Poised!: Polycomb target genes are bound by poised RNA polymerase II throughout differentiation

Rada-Iglesias A Mol. Syst. Biol. 2017 10;13(10):950 PMID: 29061670 Abstract

Chromatin Immunoprecipitation (ChIP) Protocol for Low-abundance Embryonic Samples

Rehimi R, Bartusel M, Solinas F, Altmüller J, Rada-Iglesias A J Vis Exp 2017 08;(126) PMID: 28872116 Abstract Chromatin immunoprecipitation (ChIP) is a widely-used...   Read More

PRC2 Facilitates the Regulatory Topology Required for Poised Enhancer Function during Pluripotent Stem Cell Differentiation

Cruz-Molina S, Respuela P, Tebartz C, Kolovos P, Nikolic M, Fueyo R, van Ijcken WFJ, Grosveld F, Frommolt P, Bazzi H, Rada-Iglesias A Cell...   Read More

GARLIC: a bioinformatic toolkit for aetiologically connecting diseases and cell type-specific regulatory maps

Nikolic M, Papantonis A, Rada-Iglesias A Hum. Mol. Genet. 2017 02;26(4):742-752 PMID: 28007912 Abstract Genome-wide association studies (GWAS) have emerged as a powerful tool...   Read More

Epigenomics-Based Identification of Major Cell Identity Regulators within Heterogeneous Cell Populations

Rehimi R, Nikolic M, Cruz-Molina S, Tebartz C, Frommolt P, Mahabir E, Clément-Ziza M, Rada-Iglesias A Cell Rep 2016 12;17(11):3062-3076 PMID: 27974217 Abstract Cellular...   Read More

Foxd3 Promotes Exit from Naive Pluripotency through Enhancer Decommissioning and Inhibits Germline Specification

Respuela P, Nikolić M, Tan M, Frommolt P, Zhao Y, Wysocka J, Rada-Iglesias A Cell Stem Cell 2016 Jan;18(1):118-33 PMID: 26748758 Abstract Following implantation,...   Read More

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