Fasting-Induced Transcription Factors Repress Vitamin D Bioactivation, a Mechanism for Vitamin D Deficiency in Diabetes

March 4, 2019A14 WIESNER

Aatsinki SM, Elkhwanky MS, Kummu O, Karpale M, Buler M, Viitala P, Rinne V, Mutikainen M, Tavi P, Franko A, Wiesner RJ, Chambers KT,... Read More

Augmented contractility of murine femoral arteries in a streptozotocin diabetes model is related to increased phosphorylation of MYPT1

February 10, 2019A14 WIESNER

Lubomirov LT, Gagov H, Schroeter MM, Wiesner RJ, Franko A Physiol Rep 2019 Feb;7(3):e13975 PMID: 30740930 Abstract Diabetes mellitus (DM) is a metabolic disorder... Read More

Imbalance of Mitochondrial Respiratory Chain Complexes in the Epidermis Induces Severe Skin Inflammation

May 4, 2017A1 NIESSEN A14 WIESNER

Weiland D, Brachvogel B, Hornig-Do HT, Neuhaus JFG, Holzer T, Tobin DJ, Niessen CM, Wiesner RJ, Baris OR J. Invest. Dermatol. 2017 Aug; PMID:... Read More

Correction: A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity

March 29, 2016A14 WIESNER

Kumar V, Bouameur JE, Bär J, Rice RH, Hornig-Do HT, Roop DR, Schwarz N, Brodesser S, Thiering S, Leube RE, Wiesner RJ, Vijayaraj P,... Read More

Catecholamine Metabolism Induces Mitochondrial DNA Deletions and Leads to Severe Adrenal Degeneration during Aging

February 19, 2016A14 WIESNER

Neuhaus JF, Baris OR, Kittelmann A, Becker K, Rothschild MA, Wiesner RJ Neuroendocrinology 2017;104(1):72-84 PMID: 26895241 Abstract BACKGROUND: Aging is a multifactorial process characterized... Read More

Mosaic Deficiency in Mitochondrial Oxidative Metabolism Promotes Cardiac Arrhythmia during Aging

May 9, 2015A14 WIESNER

Baris OR, Ederer S, Neuhaus JF, von Kleist-Retzow JC, Wunderlich CM, Pal M, Wunderlich FT, Peeva V, Zsurka G, Kunz WS, Hickethier T, Bunck... Read More

Mitochondrial function in murine skin epithelium is crucial for hair follicle morphogenesis and epithelial-mesenchymal interactions

November 5, 2014A14 WIESNER A3 NIEMANNKloepper JE, Baris OR, Reuter K, Kobayashi K, Weiland D, Vidali S, Tobin DJ, Niemann C, Wiesner RJ, Paus R; J Invest Dermatol. 2015 Mar;135(3):679-89. doi: 10.1038/jid.2014.475. Epub 2014 Nov 5.

Abstract Here, we studied how epithelial energy metabolism impacts overall skin development by selectively deleting intraepithelial mtDNA in mice by ablating a key maintenance... Read More

Embelin inhibits endothelial mitochondrial respiration and impairs neoangiogenesis during tumor growth and wound healing

May 7, 2014A14 WIESNER B7 EMING

Coutelle O, Hornig-Do HT, Witt A, Andree M, Schiffmann LM, Piekarek M, Brinkmann K, Seeger JM, Liwschitz M, Miwa S, Hallek M, Krönke M,... Read More

Catecholamine metabolism drives generation of mitochondrial DNA deletions in dopaminergic neurons

February 6, 2014A14 WIESNER

Neuhaus JF, Baris OR, Hess S, Moser N, Schröder H, Chinta SJ, Andersen JK, Kloppenburg P, Wiesner RJ Brain 2014 Feb;137(Pt 2):354-65 PMID: 24163249... Read More

Nonsense mutations in the COX1 subunit impair the stability of respiratory chain complexes rather than their assembly

March 7, 2012A14 WIESNER

Hornig-Do HT, Tatsuta T, Buckermann A, Bust M, Kollberg G, Rötig A, Hellmich M, Nijtmans L, Wiesner RJ EMBO J. 2012 Mar;31(5):1293-307 PMID: 22252130... Read More

A14 WIESNER