A3 NIEMANN

Hair follicle stem cell cultures reveal self-organizing plasticity of stem cells and their progeny

Chacón-Martínez CA, Klose M, Niemann C, Glauche I, Wickström SA EMBO J. 2017 Jan;36(2):151-164 PMID: 27940653 Abstract Understanding how complex tissues are formed, maintained,...   Read More

Essential role of polarity protein Par3 for epidermal homeostasis through regulation of barrier function, keratinocyte differentiation and stem cell maintenance

Ali NJ, Dias Gomes M, Bauer R, Brodesser S, Niemann C, Iden S J. Invest. Dermatol. 2016 Jul; PMID: 27452221 Abstract Partitioning-defective (Par) proteins...   Read More

Mitochondrial function in murine skin epithelium is crucial for hair follicle morphogenesis and epithelial-mesenchymal interactions

A14 WIESNERA3 NIEMANNpublicationsKloepper JE, Baris OR, Reuter K, Kobayashi K, Weiland D, Vidali S, Tobin DJ, Niemann C, Wiesner RJ, Paus R; J Invest Dermatol. 2015 Mar;135(3):679-89. doi: 10.1038/jid.2014.475. Epub 2014 Nov 5.

Abstract Here, we studied how epithelial energy metabolism impacts overall skin development by selectively deleting intraepithelial mtDNA in mice by ablating a key maintenance...   Read More

A role for Rac1 activity in malignant progression of sebaceous skin tumours

A3 NIEMANNpublicationsFrances D, Sharma N, Pofahl R, Maneck M, Behrendt K, Reuter K, Krieg T, Klein CA, Haase I, Niemann C; Oncogene. 2015 Oct;34(43):5505-12. doi: 10.1038/onc.2014.471. Epub 2015 Feb 9.

Abstract The small GTPase Rac1 is crucial for maintaining stem cells (SCs) in mammalian epidermis, and Rac1 activation leads to SC expansion. Loss or...   Read More

Interfering with stem cell-specific gatekeeper functions controls tumour initiation and malignant progression of skin tumours

A3 NIEMANNpublicationsPetersson M, Reuter K, Brylka H, Kraus A, Schettina P, Niemann C; Nat Commun. 2015 Jan 22;6:5874. doi: 10.1038/ncomms6874.

Abstract Epithelial cancer constitutes a major clinical challenge and molecular mechanisms underlying the process of tumour initiation are not well understood. Here we demonstrate...   Read More

Overexpression of epigen during embryonic development induces reversible, EGFR-dependent sebaceous gland hyperplasia

A3 NIEMANNpublicationsDahlhoff M, Frances D, Kloepper JE, Paus R, Schäfer M, Niemann C, Schneider MR; Mol Cell Biol. 2014 Aug;34(16):3086-95. doi: 10.1128/MCB.00302-14. Epub 2014 Jun 2.

Abstract The epidermal growth factor receptor (EGFR) system is a key regulator of epithelial development and homeostasis. Its functions in the sebaceous gland (SG),...   Read More

Indian hedgehog controls proliferation and differentiation in skin tumorigenesis and protects against malignant progression.

A3 NIEMANNpublicationsKakanj P, Reuter K, Séquaris G, Wodtke C, Schettina P, Frances D, Zouboulis CC, Lanske B, Niemann C; Cell Rep. 2013 Jul 25;4(2):340-51. doi: 10.1016/j.celrep.2013.06.037. Epub 2013 Jul 18.

Abstract   Mutations in the hedgehog pathway drive the formation of tumors in many different organs, including the development of basal cell carcinoma in...   Read More

Development and homeostasis of the sebaceous gland

Niemann C, Horsley V Semin. Cell Dev. Biol. 2012 Oct;23(8):928-36 PMID: 22960253 Abstract The important role of epidermal appendages especially the sebaceous gland has...   Read More

Stem cell dynamics in sebaceous gland morphogenesis in mouse skin

A3 NIEMANNpublicationsFrances, D., and Niemann. C., Dev Biol. 2012 Mar 1;363(1):138-46. doi: 10.1016/j.ydbio.2011.12.028. Epub 2011 Dec 27.

Abstract The hair follicle (HF) and the sebaceous gland (SG) constitute the two integral parts of the pilosebaceous unit and significantly contribute to the...   Read More

A function for Rac1 in the terminal differentiation and pigmentation of hair

A3 NIEMANNA5 BRÜNING/NIESSENpublications Behrendt K, Klatte J, Pofahl R, Bloch W, Smyth N, Tscharntke M, Krieg T, Paus R, Niessen CM, Niemann C, Brakebusch C, Haase I; J Cell Sci. 2012 Feb 15;125(Pt 4):896-905. doi: 10.1242/jcs.091868. Epub 2012 Jan 24.

Abstract The small GTPase Rac1 is ubiquitously expressed in proliferating and differentiating layers of the epidermis and hair follicles. Previously, Rac1 was shown to...   Read More

  • Upcoming Events

    1. 4th PhD student and Postdoc Minisymposium

      Juli 7 @ 3:00 pm - 5:00 pm
    2. 4th German-French DNA Repair Meeting Cologne 2017

      September 21 - September 23
    3. 33. Klenk Symposium 2017 in Molecular Medicine

      Oktober 15 - Oktober 17

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