A4 PASPARAKIS

RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation

Lin J, Kumari S, Kim C, Van TM, Wachsmuth L, Polykratis A, Pasparakis M Nature 2016 Dec;540(7631):124-128 PMID: 27819681 Abstract Receptor-interacting protein kinase 1...   Read More

NEMO Prevents RIP Kinase 1-Mediated Epithelial Cell Death and Chronic Intestinal Inflammation by NF-κB-Dependent and -Independent Functions

Vlantis K, Wullaert A, Polykratis A, Kondylis V, Dannappel M, Schwarzer R, Welz P, Corona T, Walczak H, Weih F, Klein U, Kelliher M,...   Read More

NEMO Prevents Steatohepatitis and Hepatocellular Carcinoma by Inhibiting RIPK1 Kinase Activity-Mediated Hepatocyte Apoptosis

Kondylis V, Polykratis A, Ehlken H, Ochoa-Callejero L, Straub BK, Krishna-Subramanian S, Van TM, Curth HM, Heise N, Weih F, Klein U, Schirmacher P,...   Read More

Epithelial Cell Death and Inflammation in Skin

Kumari S, Pasparakis M Curr. Top. Microbiol. Immunol. 2015 Aug; PMID: 26275873 Abstract The presence of dying cells in inflamed tissues has been recognized...   Read More

Necroptosis and its role in inflammation

Pasparakis M, Vandenabeele P Nature 2015 Jan;517(7534):311-20 PMID: 25592536 Abstract Regulated cell death has essential functions in development and in adult tissue homeostasis. Necroptosis...   Read More

Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis

A4 PASPARAKISpublicationsKumari S, Redouane Y, Lopez-Mosqueda J, Shiraishi R, Romanowska M, Lutzmayer S, Kuiper J, Martinez C, Dikic I, Pasparakis M, Ikeda F; Elife. 2014 Dec 2;3. doi: 10.7554/eLife.03422.

Abstract Linear Ubiquitin chain Assembly Complex (LUBAC) is an E3 ligase complex that generates linear ubiquitin chains and is important for tumour necrosis factor...   Read More

RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis

Dannappel M, Vlantis K, Kumari S, Polykratis A, Kim C, Wachsmuth L, Eftychi C, Lin J, Corona T, Hermance N, Zelic M, Kirsch P,...   Read More

Epidermal p65/NF-κB signalling is essential for skin carcinogenesis

Kim C, Pasparakis M EMBO Mol Med 2014 Jul;6(7):970-83 PMID: 24952939 Abstract The nuclear factor kappa B (NF-κB) signalling pathway exhibits both tumour-promoting and...   Read More

Mechanisms regulating skin immunity and inflammation

Pasparakis M, Haase I, Nestle FO Nat. Rev. Immunol. 2014 May;14(5):289-301 PMID: 24722477 Abstract Immune responses in the skin are important for host defence...   Read More

Tumor necrosis factor receptor signaling in keratinocytes triggers interleukin-24-dependent psoriasis-like skin inflammation in mice

A4 PASPARAKISpublications Kumari S, Bonnet MC, Ulvmar MH, Wolk K, Karagianni N, Witte E, Uthoff-Hachenberg C, Renauld JC, Kollias G, Toftgard R, Sabat R, Pasparakis M, Haase I; Immunity. 2013 Nov 14;39(5):899-911. doi: 10.1016/j.immuni.2013.10.009. Epub 2013 Nov 7.

Abstract Psoriasis is a common chronic inflammatory skin disease with a prevalence of about 2% in the Caucasian population. Tumor necrosis factor (TNF) plays...   Read More

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