RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation

November 7, 2016A4 PASPARAKIS publications

Lin J, Kumari S, Kim C, Van TM, Wachsmuth L, Polykratis A, Pasparakis M Nature 2016 Dec;540(7631):124-128 PMID: 27819681 Abstract Receptor-interacting protein kinase 1... Read More

NEMO Prevents RIP Kinase 1-Mediated Epithelial Cell Death and Chronic Intestinal Inflammation by NF-κB-Dependent and -Independent Functions

March 17, 2016A4 PASPARAKIS publications

Vlantis K, Wullaert A, Polykratis A, Kondylis V, Dannappel M, Schwarzer R, Welz P, Corona T, Walczak H, Weih F, Klein U, Kelliher M,... Read More

NEMO Prevents Steatohepatitis and Hepatocellular Carcinoma by Inhibiting RIPK1 Kinase Activity-Mediated Hepatocyte Apoptosis

November 11, 2015A4 PASPARAKIS publications

Kondylis V, Polykratis A, Ehlken H, Ochoa-Callejero L, Straub BK, Krishna-Subramanian S, Van TM, Curth HM, Heise N, Weih F, Klein U, Schirmacher P,... Read More

Epithelial Cell Death and Inflammation in Skin

August 15, 2015A4 PASPARAKIS

Kumari S, Pasparakis M Curr. Top. Microbiol. Immunol. 2015 Aug; PMID: 26275873 Abstract The presence of dying cells in inflamed tissues has been recognized... Read More

Necroptosis and its role in inflammation

January 16, 2015A4 PASPARAKIS

Pasparakis M, Vandenabeele P Nature 2015 Jan;517(7534):311-20 PMID: 25592536 Abstract Regulated cell death has essential functions in development and in adult tissue homeostasis. Necroptosis... Read More

Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis

December 2, 2014A4 PASPARAKIS publicationsKumari S, Redouane Y, Lopez-Mosqueda J, Shiraishi R, Romanowska M, Lutzmayer S, Kuiper J, Martinez C, Dikic I, Pasparakis M, Ikeda F; Elife. 2014 Dec 2;3. doi: 10.7554/eLife.03422.

Abstract Linear Ubiquitin chain Assembly Complex (LUBAC) is an E3 ligase complex that generates linear ubiquitin chains and is important for tumour necrosis factor... Read More

RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis

September 4, 2014A4 PASPARAKIS

Dannappel M, Vlantis K, Kumari S, Polykratis A, Kim C, Wachsmuth L, Eftychi C, Lin J, Corona T, Hermance N, Zelic M, Kirsch P,... Read More

Epidermal p65/NF-κB signalling is essential for skin carcinogenesis

July 4, 2014A4 PASPARAKIS

Kim C, Pasparakis M EMBO Mol Med 2014 Jul;6(7):970-83 PMID: 24952939 Abstract The nuclear factor kappa B (NF-κB) signalling pathway exhibits both tumour-promoting and... Read More

Mechanisms regulating skin immunity and inflammation

April 25, 2014A4 PASPARAKIS

Pasparakis M, Haase I, Nestle FO Nat. Rev. Immunol. 2014 May;14(5):289-301 PMID: 24722477 Abstract Immune responses in the skin are important for host defence... Read More

Tumor necrosis factor receptor signaling in keratinocytes triggers interleukin-24-dependent psoriasis-like skin inflammation in mice

November 7, 2013A4 PASPARAKIS publications Kumari S, Bonnet MC, Ulvmar MH, Wolk K, Karagianni N, Witte E, Uthoff-Hachenberg C, Renauld JC, Kollias G, Toftgard R, Sabat R, Pasparakis M, Haase I; Immunity. 2013 Nov 14;39(5):899-911. doi: 10.1016/j.immuni.2013.10.009. Epub 2013 Nov 7.

Abstract Psoriasis is a common chronic inflammatory skin disease with a prevalence of about 2% in the Caucasian population. Tumor necrosis factor (TNF) plays... Read More

A4 PASPARAKIS

RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation

NEMO Prevents RIP Kinase 1-Mediated Epithelial Cell Death and Chronic Intestinal Inflammation by NF-κB-Dependent and -Independent Functions

NEMO Prevents Steatohepatitis and Hepatocellular Carcinoma by Inhibiting RIPK1 Kinase Activity-Mediated Hepatocyte Apoptosis

Epithelial Cell Death and Inflammation in Skin

Necroptosis and its role in inflammation

Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis

RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis

Epidermal p65/NF-κB signalling is essential for skin carcinogenesis

Mechanisms regulating skin immunity and inflammation

Tumor necrosis factor receptor signaling in keratinocytes triggers interleukin-24-dependent psoriasis-like skin inflammation in mice

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