A4 PASPARAKIS

A20 prevents inflammasome-dependent arthritis by inhibiting macrophage necroptosis through its ZnF7 ubiquitin-binding domain

Polykratis A, Martens A, Eren RO, Shirasaki Y, Yamagishi M, Yamaguchi Y, Uemura S, Miura M, Holzmann B, Kollias G, Armaka M, van Loo...   Read More

Corticosteroids inhibit Mycobacterium tuberculosis-induced necrotic host cell death by abrogating mitochondrial membrane permeability transition

Gräb J, Suárez I, van Gumpel E, Winter S, Schreiber F, Esser A, Hölscher C, Fritsch M, Herb M, Schramm M, Wachsmuth L, Pallasch...   Read More

Innate Sensing through Mesenchymal TLR4/MyD88 Signals Promotes Spontaneous Intestinal Tumorigenesis

Koliaraki V, Chalkidi N, Henriques A, Tzaferis C, Polykratis A, Waisman A, Muller W, Hackam DJ, Pasparakis M, Kollias G Cell Rep 2019 Jan;26(3):536-545.e4...   Read More

RIPK1 and Caspase-8 Ensure Chromosome Stability Independently of Their Role in Cell Death and Inflammation

Liccardi G, Ramos Garcia L, Tenev T, Annibaldi A, Legrand AJ, Robertson D, Feltham R, Anderton H, Darding M, Peltzer N, Dannappel M, Schünke...   Read More

RIP Kinases in Liver Cell Death, Inflammation and Cancer

Kondylis V, Pasparakis M Trends Mol Med 2019 Jan;25(1):47-63 PMID: 30455045 Abstract Cell death is intrinsically linked to inflammatory liver disease and cancer development....   Read More

ATG16L1 orchestrates interleukin-22 signaling in the intestinal epithelium via cGAS-STING

Aden K, Tran F, Ito G, Sheibani-Tezerji R, Lipinski S, Kuiper JW, Tschurtschenthaler M, Saveljeva S, Bhattacharyya J, Häsler R, Bartsch K, Luzius A,...   Read More

Connecting immune deficiency and inflammation

Pasparakis M, Kelliher M Science 2018 08;361(6404):756-757 PMID: 30139862 Abstract

Differential role of MyD88 and TRIF signaling in myeloid cells in the pathogenesis of autoimmune diabetes

Androulidaki A, Wachsmuth L, Polykratis A, Pasparakis M PLoS ONE 2018;13(3):e0194048 PMID: 29522531 Abstract Type 1 diabetes (T1D) is caused by the autoimmune destruction...   Read More

Kinase-independent functions of RIPK1 regulate hepatocyte survival and liver carcinogenesis

Van TM, Polykratis A, Straub BK, Kondylis V, Papadopoulou N, Pasparakis M J. Clin. Invest. 2017 Jun;127(7):2662-2677 PMID: 28628031 Abstract The mechanisms that regulate...   Read More

The interplay of IKK, NF-κB and RIPK1 signaling in the regulation of cell death, tissue homeostasis and inflammation

Kondylis V, Kumari S, Vlantis K, Pasparakis M Immunol. Rev. 2017 05;277(1):113-127 PMID: 28462531 Abstract Regulated cell death pathways have important functions in host...   Read More

  • Upcoming Events

    1. 4th Connector Meeting

      September 6 @ 3:00 pm - 6:30 pm
    2. 5th Connector Meeting

      November 8 @ 3:00 pm - 6:00 pm

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