CCR2 recruits an inflammatory macrophage subpopulation critical for angiogenesis in tissue repair

A4 PASPARAKISA7 SCHUMACHERpublicationsLucas, T., Willenborg, S., van Loo, G., Knipper, J., Krieg, T., Haase, I., Brachvogel, B., Nagy, A., Ferrara, N., Pasparakis, M., and Eming, S., Blood. 2012 Jul 19;120(3):613-25. doi: 10.1182/blood-2012-01-403386. Epub 2012 May 10.

Abstract Monocytes/macrophages are critical in orchestrating the tissue-repair response. However, the mechanisms that govern macrophage regenerative activities during the sequential phases of repair are...   Read More

Role of NF-κB in epithelial biology

A4 PASPARAKISpublicationsPasparakis, M., Immunol Rev. 2012 Mar;246(1):346-58. doi: 10.1111/j.1600-065X.2012.01109.x.

Abstract Since its discovery, nuclear factor-κB (NF-κB) has been recognized as a critical regulator of immune responses. While early studies focused on studying the...   Read More

The adapter protein FADD protects epidermal keratinocytes from necroptosis in vivo and prevents skin inflammation

A4 PASPARAKISpublicationsBonnet MC, Preukschat D, Welz PS, van Loo G, Ermolaeva M, Bloch W, Haase I, Pasparakis M (2011) Immunity ,2011 Oct 28;35(4):572-82. Epub 2011 Oct 13.

Abstract Epidermal keratinocytes provide an essential structural and immunological barrier forming the first line of defense against potentially pathogenic microorganisms. Mechanisms regulating barrier integrity...   Read More

Constitutive IKK2 activation in intestinal epithelial cells induces intestinal tumors in mice

A4 PASPARAKISpublications Vlantis K, Wullaert A, Sasaki Y, Schmidt-Supprian M, Rajewsky K, Roskams T, Pasparakis M., J Clin Invest. 2011, 121(7):2781-93

Abstract Many cancers display increased NF-κB activity, and NF-κB inhibition is known to diminish tumor development in multiple mouse models, supporting an important role...   Read More

FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation

A4 PASPARAKISpublications Welz PS, Wullaert A, Vlantis K, Kondylis V, Fernández-Majada V, Ermolaeva M, Kirsch P, Sterner-Kock A, van Loo G, Pasparakis M., Nature. 2011 Jul 31. doi: 10.1038/nature10273

Abstract Intestinal immune homeostasis depends on a tightly regulated cross talk between commensal bacteria, mucosal immune cells and intestinal epithelial cells (IECs). Epithelial barrier...   Read More

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