A5 BRÜNING/NIESSEN

Imbalance of Mitochondrial Respiratory Chain Complexes in the Epidermis Induces Severe Skin Inflammation

Weiland D, Brachvogel B, Hornig-Do HT, Neuhaus JFG, Holzer T, Tobin DJ, Niessen CM, Wiesner RJ, Baris OR J. Invest. Dermatol. 2017 Aug; PMID:...   Read More

The Mitochondrial m-AAA Protease Prevents Demyelination and Hair Greying

Wang S, Jacquemyn J, Murru S, Martinelli P, Barth E, Langer T, Niessen CM, Rugarli EI PLoS Genet. 2016 Dec;12(12):e1006463 PMID: 27911893 Abstract The...   Read More

Myeloid Cell-Restricted Insulin/IGF-1 Receptor Deficiency Protects against Skin Inflammation

A5 BRÜNING/NIESSENB7 EMINGpublicationsKnuever J, Willenborg S, Ding X, Akyüz MD, Partridge L, Niessen CM, Brüning JC, Eming SA; J Immunol. 2015 Dec 1;195(11):5296-308. doi: 10.4049/jimmunol.1501237. Epub 2015 Oct 30.

Abstract Myeloid cells are key regulators of tissue homeostasis and disease. Alterations in cell-autonomous insulin/IGF-1 signaling in myeloid cells have recently been implicated in...   Read More

Ceramide synthase 4 regulates stem cell homeostasis and hair follicle cycling

Peters F, Vorhagen S, Brodesser S, Jakobshagen K, Brüning JC, Niessen CM, Krönke M J. Invest. Dermatol. 2015 Jun;135(6):1501-9 PMID: 25705848 Abstract Ceramides are...   Read More

NK cells link obesity-induced adipose stress to inflammation and insulin resistance

A5 BRÜNING/NIESSENpublicationsWensveen FM, Jelen?i? V, Valenti? S, Šestan M, Wensveen TT, Theurich S, Glasner A, Mendrila D, Štimac D, Wunderlich FT, Brüning JC, Mandelboim O, Poli? B; Nat Immunol. 2015 Apr;16(4):376-85. doi: 10.1038/ni.3120. Epub 2015 Mar 2.

Abstract An important cause of obesity-induced insulin resistance is chronic systemic inflammation originating in visceral adipose tissue (VAT). VAT inflammation is associated with the...   Read More

Epidermal Polarity Genes in Health and Disease

A5 BRÜNING/NIESSENpublicationsTellkamp F, Vorhagen S, Niessen CM; Cold Spring Harb Perspect Med. 2014 Dec 1;4(12):a015255. doi: 10.1101/cshperspect.a015255.

Abstract The epidermis of the skin is a highly polarized, metabolic tissue with important innate immune functions. The polarity of the epidermis is, for...   Read More

Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin

A5 BRÜNING/NIESSENpublicationsMauer J, Chaurasia B, Goldau J, Vogt MC, Ruud J, Nguyen KD, Theurich S, Hausen AC, Schmitz J, Brönneke HS, Estevez E, Allen TL, Mesaros A, Partridge L, Febbraio MA, Chawla A, Wunderlich FT, Brüning JC; Nat Immunol. 2014 May;15(5):423-30. doi: 10.1038/ni.2865. Epub 2014 Mar 30.

Abstract Obesity and resistance to insulin are closely associated with the development of low-grade inflammation. Interleukin 6 (IL-6) is linked to obesity-associated inflammation; however,...   Read More

Insulin/IGF-1 controls epidermal morphogenesis via regulation of FoxO-mediated p63 inhibition

A5 BRÜNING/NIESSENpublications Günschmann C, Stachelscheid H, Akyüz MD, Schmitz A, Missero C, Brüning JC, Niessen CM; Dev Cell. 2013 Jul 29;26(2):176-87. doi: 10.1016/j.devcel.2013.05.017

Abstract   The multilayered epidermis is established through a stratification program, which is accompanied by a shift from symmetric toward asymmetric divisions (ACD), a...   Read More

Analysis of bulge stem cells from the epidermis using flow cytometry

A5 BRÜNING/NIESSENpublicationsVillani RM, Akyuz MD, Niessen MT, Niessen CM; Methods Mol Biol. 2013;989:33-43. doi: 10.1007/978-1-62703-330-5_4.

Abstract The epidermis is a multilayered epithelium consisting of multiple different progenitor cell populations, all of which are important to epidermal function. In order...   Read More

Montagna Symposium 2012: Keeping it all together–adhesion, the cytoskeleton, and signaling in morphogenesis and tissue function

A5 BRÜNING/NIESSENpublicationsGreen KJ, Niessen CM, Godsel LM, Kulesz-Martin MF, J Invest Dermatol. 2013 May;133(5):1124-8. doi: 10.1038/jid.2013.59.

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