A5 BRÜNING/NIESSEN

Montagna Symposium 2012: Keeping it all together–adhesion, the cytoskeleton, and signaling in morphogenesis and tissue function

A1 NIESSENA5 BRÜNING/NIESSENpublicationsGreen KJ, Niessen CM, Godsel LM, Kulesz-Martin MF; J Invest Dermatol. 2013 May;133(5):1124-8. doi: 10.1038/jid.2013.59.

Pubmed

Experimental analysis of risk factors for ulcerative dermatitis in mice

A1 NIESSENA5 BRÜNING/NIESSENpublicationsNeuhaus, B., Niessen C.M., Mesaros A., Withers D.J., Krieg T. and Partridge L., Exp Dermatol. 2012 Sep;21(9):712-3. doi: 10.1111/j.1600-0625.2012.01558.x.

Abstract Ulcerative dermatitis (UD) is a severe inflammatory skin disorder with an unknown aetiology. Recently, insulin receptor substrate 1 KO mice were shown to...   Read More

Vascular endothelial insulin/IGF-1 signaling controls skin wound vascularization

A1 NIESSENA5 BRÜNING/NIESSENpublications Aghdam SY, Eming SA, Willenborg S, Neuhaus B, Niessen CM, Partridge L, Krieg T, Bruning JC, Biochem Biophys Res Commun. 2012 May 4;421(2):197-202. doi: 10.1016/j.bbrc.2012.03.134. Epub 2012 Apr 4.

Abstract Type 2 diabetes mellitus affects 6% of western populations and represents a major risk factor for the development of skin complications, of which...   Read More

Dwarfism in mice lacking collagen-binding integrins α2β1 and α11β1 is caused by severely diminished IGF-1 levels

A5 BRÜNING/NIESSENB3 ECKES KRIEGpublicationsBlumbach, K., Niehoff, A., Belgardt, B.F., Ehlen, H.W., Schmitz, M., Hallinger, R., Schulz, J.N., Brüning, J.C., Krieg, T., Schubert, M., Gullberg, D., and Eckes, B., J Biol Chem. 2012 Feb 24;287(9):6431-40. doi: 10.1074/jbc.M111.283119. Epub 2011 Dec 30.

Abstract Mice with a combined deficiency in the α2β1 and α11β1 integrins lack the major receptors for collagen I. These mutants are born with...   Read More

A function for Rac1 in the terminal differentiation and pigmentation of hair

A3 NIEMANNA5 BRÜNING/NIESSENpublications Behrendt K, Klatte J, Pofahl R, Bloch W, Smyth N, Tscharntke M, Krieg T, Paus R, Niessen CM, Niemann C, Brakebusch C, Haase I; J Cell Sci. 2012 Feb 15;125(Pt 4):896-905. doi: 10.1242/jcs.091868. Epub 2012 Jan 24.

Abstract The small GTPase Rac1 is ubiquitously expressed in proliferating and differentiating layers of the epidermis and hair follicles. Previously, Rac1 was shown to...   Read More

Persistent transcription-blocking DNA lesions trigger somatic growth attenuation associated with longevity (2009)

A5 BRÜNING/NIESSENA7 SCHUMACHERB15 HOEIJMAKERSpublications Garinis GA, Uittenboogaard LM, Stachelscheid H, Fousteri M, van Ijcken W, Breit TM, van Steeg H, Mullenders LHF, van der Horst GTJ, Brüning JC, Niessen CM, Hoeijmakers JHJ and Schumacher B, Nature Cell Biol. 2009 May;11(5):604-15.

Abstract: The accumulation of stochastic DNA damage throughout an organism’s lifespan is thought to contribute to ageing. Conversely, ageing seems to be phenotypically reproducible...   Read More

Epidermal Insulin/IGF-1 signaling control interfollicular morphogenesis and proliferative potential via Rac activation (2008)

A5 BRÜNING/NIESSENpublications Stachelscheid. H.*, Ibrahim, H.*, Koch, L., Schmitz, A., Tscharntke, M., Wunderlich F.T., Scott, J. Michels, C., Haase I., Wickenhauser, C., Brüning, J and Niessen C.M. EMBO J. 27:2091-101.

Abstract The lifelong self-renewal of the epidermis is driven by a progenitor cell population with high proliferative potential. To date, the upstream signals that...   Read More

Persistent transcription-blocking DNA lesions trigger somatic growth attenuation associated with longevity

A5 BRÜNING/NIESSENA7 SCHUMACHERB15 HOEIJMAKERSpublications Garinis, G.A., Uittenboogaard L.M., Stachelscheid H., van Ijcken, W. , Breit T.M., van Steeg H., Mullenders L.H.F., van der Horst G.T.J., Brüning J.C., Niessen C.M., Hoeijmakers J.H.J, and Schumacher B. Nat. Cell Biol.. 11:604-15.

Abstract The accumulation of stochastic DNA damage throughout an organism’s lifespan is thought to contribute to ageing. Conversely, ageing seems to be phenotypically reproducible...   Read More

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    1. Klenk Symposium 2017 – Tissue regeneration, wound healing and fibrosis: Translating basic concepts into regenerative therapy

      Oktober 15 - Oktober 17

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