A7 SCHUMACHER

p53 in the DNA-Damage-Repair Process

Williams AB, Schumacher B Cold Spring Harb Perspect Med 2016;6(5) PMID: 27048304 Abstract The cells in the human body are continuously challenged by a...   Read More

A C. elegans homolog for the UV-hypersensitivity syndrome disease gene UVSSA

Babu V, Schumacher B DNA Repair (Amst.) 2016 May;41:8-15 PMID: 27043179 Abstract The transcription-coupled repair pathway (TC-NER) plays a vital role in removing transcription-blocking...   Read More

Systemic DNA damage responses in aging and diseases

Ribezzo F, Shiloh Y, Schumacher B Semin. Cancer Biol. 2016 Jan; PMID: 26773346 Abstract The genome is constantly attacked by a variety of genotoxic...   Read More

Longevity through DNA damage tolerance

A7 SCHUMACHERpublicationsCastells-Roca L, Mueller MM, Schumacher B; Cell Cycle. 2015;14(4):467-8. doi: 10.1080/15384101.2015.1006543.

Pubmed

Genome Instability in Development and Aging: Insights from Nucleotide Excision Repair in Humans, Mice, and Worms

A7 SCHUMACHERpublicationsEdifizi D, Schumacher B; Biomolecules. 2015 Aug 13;5(3):1855-69. doi: 10.3390/biom5031855.

Abstract DNA damage causally contributes to aging and cancer. Congenital defects in nucleotide excision repair (NER) lead to distinct cancer-prone and premature aging syndromes....   Read More

DNA repair mechanisms in cancer development and therapy

A7 SCHUMACHERpublicationsTorgovnick A, Schumacher B; Front Genet. 2015 Apr 23;6:157. doi: 10.3389/fgene.2015.00157. eCollection 2015.

Abstract: DNA damage has been long recognized as causal factor for cancer development. When erroneous DNA repair leads to mutations or chromosomal aberrations affecting...   Read More

Wormpath: searching for molecular interaction networks in Caenorhabditis elegans

A7 SCHUMACHERpublicationsFrommolt P, Schumacher B; Source Code Biol Med. 2015 Apr 2;10:5. doi: 10.1186/s13029-015-0034-6. eCollection 2015.

Abstract Background: High-throughput transcriptional profiling using Next-Generation Sequencing (RNA-Seq) or microarray technology have become standard tools in molecular biology. Successful investigations of gene regulatory...   Read More

Quality control mechanisms in cellular and systemic DNA damage responses

A7 SCHUMACHERpublications Ermolaeva MA, Dakhovnik A, Schumacher B; Ageing Res Rev. 2015 Sep;23(Pt A):3-11. doi: 10.1016/j.arr.2014.12.009. Epub 2015 Jan 3.

Abstract The maintenance of the genome is of pivotal importance for the functional integrity of cells and tissues. The gradual accumulation of DNA damage...   Read More

DAF-16/FOXO and EGL-27/GATA promote developmental growth in response to persistent somatic DNA damage

A7 SCHUMACHERpublicationsMueller MM, Castells-Roca L, Babu V, Ermolaeva MA, Müller RU, Frommolt P, Williams AB, Greiss S, Schneider JI, Benzing T, Schermer B, Schumacher B; Nat Cell Biol. 2014 Dec;16(12):1168-79. doi: 10.1038/ncb3071. Epub 2014 Nov 24.

Abstract Genome maintenance defects cause complex disease phenotypes characterized by developmental failure, cancer susceptibility and premature ageing. It remains poorly understood how DNA damage...   Read More

A C. elegans homolog of the Cockayne syndrome complementation group A gene

A7 SCHUMACHERpublicationsBabu V, Hofmann K, Schumacher B; DNA Repair (Amst). 2014 Dec;24:57-62. doi: 10.1016/j.dnarep.2014.09.011. Epub 2014 Nov 8.

Abstract Cockayne syndrome (CS) is a debilitating and complex disorder that results from inherited mutations in the CS complementation genes A and B, CSA...   Read More

  • Upcoming Events

    1. SFB Minisymposium – New Technologies for Dermatology

      August 29 @ 1:00 pm - 6:00 pm
    2. 4th German-French DNA Repair Meeting Cologne 2017

      September 21 - September 23
    3. Klenk Symposium 2017 – Tissue regeneration, wound healing and fibrosis: Translating basic concepts into regenerative therapy

      Oktober 15 - Oktober 17

© 2017 SFB 829