Williams AB, Schumacher B Cold Spring Harb Perspect Med 2016;6(5) PMID: 27048304 Abstract The cells in the human body are continuously challenged by a... Read More
Babu V, Schumacher B DNA Repair (Amst.) 2016 May;41:8-15 PMID: 27043179 Abstract The transcription-coupled repair pathway (TC-NER) plays a vital role in removing transcription-blocking... Read More
Ribezzo F, Shiloh Y, Schumacher B Semin. Cancer Biol. 2016 Jan; PMID: 26773346 Abstract The genome is constantly attacked by a variety of genotoxic... Read More
Abstract DNA damage causally contributes to aging and cancer. Congenital defects in nucleotide excision repair (NER) lead to distinct cancer-prone and premature aging syndromes.... Read More
Abstract: DNA damage has been long recognized as causal factor for cancer development. When erroneous DNA repair leads to mutations or chromosomal aberrations affecting... Read More
Abstract Background: High-throughput transcriptional profiling using Next-Generation Sequencing (RNA-Seq) or microarray technology have become standard tools in molecular biology. Successful investigations of gene regulatory... Read More
Abstract The maintenance of the genome is of pivotal importance for the functional integrity of cells and tissues. The gradual accumulation of DNA damage... Read More
Abstract Genome maintenance defects cause complex disease phenotypes characterized by developmental failure, cancer susceptibility and premature ageing. It remains poorly understood how DNA damage... Read More
Abstract Cockayne syndrome (CS) is a debilitating and complex disorder that results from inherited mutations in the CS complementation genes A and B, CSA... Read More
