A7 SCHUMACHER

A simple answer to complex questions: Caenorhabditis elegans as an experimental model for examining the DNA damage response and disease genes

Rieckher M, Bujarrabal A, Doll MA, Soltanmohammadi N, Schumacher B J. Cell. Physiol. 2017 May; PMID: 28463453 Abstract The genetic information is constantly challenged...   Read More

E4 ligase-specific ubiquitination hubs coordinate DNA double-strand-break repair and apoptosis

Ackermann L, Schell M, Pokrzywa W, Kevei É, Gartner A, Schumacher B, Hoppe T Nat. Struct. Mol. Biol. 2016 Nov;23(11):995-1002 PMID: 27669035 Abstract Multiple...   Read More

p53 in the DNA-Damage-Repair Process

Williams AB, Schumacher B Cold Spring Harb Perspect Med 2016;6(5) PMID: 27048304 Abstract The cells in the human body are continuously challenged by a...   Read More

A C. elegans homolog for the UV-hypersensitivity syndrome disease gene UVSSA

Babu V, Schumacher B DNA Repair (Amst.) 2016 May;41:8-15 PMID: 27043179 Abstract The transcription-coupled repair pathway (TC-NER) plays a vital role in removing transcription-blocking...   Read More

Systemic DNA damage responses in aging and diseases

Ribezzo F, Shiloh Y, Schumacher B Semin. Cancer Biol. 2016 Jan; PMID: 26773346 Abstract The genome is constantly attacked by a variety of genotoxic...   Read More

Longevity through DNA damage tolerance

A7 SCHUMACHERpublicationsCastells-Roca L, Mueller MM, Schumacher B; Cell Cycle. 2015;14(4):467-8. doi: 10.1080/15384101.2015.1006543.

Pubmed

Genome Instability in Development and Aging: Insights from Nucleotide Excision Repair in Humans, Mice, and Worms

A7 SCHUMACHERpublicationsEdifizi D, Schumacher B; Biomolecules. 2015 Aug 13;5(3):1855-69. doi: 10.3390/biom5031855.

Abstract DNA damage causally contributes to aging and cancer. Congenital defects in nucleotide excision repair (NER) lead to distinct cancer-prone and premature aging syndromes....   Read More

DNA repair mechanisms in cancer development and therapy

A7 SCHUMACHERpublicationsTorgovnick A, Schumacher B; Front Genet. 2015 Apr 23;6:157. doi: 10.3389/fgene.2015.00157. eCollection 2015.

Abstract: DNA damage has been long recognized as causal factor for cancer development. When erroneous DNA repair leads to mutations or chromosomal aberrations affecting...   Read More

Wormpath: searching for molecular interaction networks in Caenorhabditis elegans

A7 SCHUMACHERpublicationsFrommolt P, Schumacher B; Source Code Biol Med. 2015 Apr 2;10:5. doi: 10.1186/s13029-015-0034-6. eCollection 2015.

Abstract Background: High-throughput transcriptional profiling using Next-Generation Sequencing (RNA-Seq) or microarray technology have become standard tools in molecular biology. Successful investigations of gene regulatory...   Read More

Quality control mechanisms in cellular and systemic DNA damage responses

A7 SCHUMACHERpublications Ermolaeva MA, Dakhovnik A, Schumacher B; Ageing Res Rev. 2015 Sep;23(Pt A):3-11. doi: 10.1016/j.arr.2014.12.009. Epub 2015 Jan 3.

Abstract The maintenance of the genome is of pivotal importance for the functional integrity of cells and tissues. The gradual accumulation of DNA damage...   Read More

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