A7 SCHUMACHER

UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors

Jachimowicz RD, Beleggia F, Isensee J, Velpula BB, Goergens J, Bustos MA, Doll MA, Shenoy A, Checa-Rodriguez C, Wiederstein JL, Baranes-Bachar K, Bartenhagen C,...   Read More

Extension of longevity and reduction of inflammation is ovarian-dependent, but germ cell-independent in post-reproductive female mice

Habermehl TL, Parkinson KC, Hubbard GB, Ikeno Y, Engelmeyer JI, Schumacher B, Mason JB Geroscience 2019 02;41(1):25-38 PMID: 30547325 Abstract Cardiovascular disease, rare in...   Read More

BRCA1 and BARD1 mediate apoptotic resistance but not longevity upon mitochondrial stress in

Torgovnick A, Schiavi A, Shaik A, Kassahun H, Maglioni S, Rea SL, Johnson TE, Reinhardt HC, Honnen S, Schumacher B, Nilsen H, Ventura N...   Read More

The Cdkn1a Mouse as a Tool to Study p53-Mediated Tumor Suppression

Torgovnick A, Heger JM, Liaki V, Isensee J, Schmitt A, Knittel G, Riabinska A, Beleggia F, Laurien L, Leeser U, Jüngst C, Siedek F,...   Read More

Maintenance of Proteostasis by P Body-Mediated Regulation of eIF4E Availability during Aging in Caenorhabditis elegans

Rieckher M, Markaki M, Princz A, Schumacher B, Tavernarakis N Cell Rep 2018 Oct;25(1):199-211.e6 PMID: 30282029 Abstract Aging is accompanied by a pervasive collapse...   Read More

MPK-1/ERK pathway regulates DNA damage response during development through DAF-16/FOXO

Bianco JN, Schumacher B Nucleic Acids Res. 2018 Jul;46(12):6129-6139 PMID: 29788264 Abstract Ultraviolet (UV) induces distorting lesions to the DNA that can lead to...   Read More

Omics Approaches for Identifying Physiological Adaptations to Genome Instability in Aging

Edifizi D, Schumacher B Int J Mol Sci 2017 Nov;18(11) PMID: 29113067 Abstract DNA damage causally contributes to aging and age-related diseases. The declining...   Read More

DNA damage responses and p53 in the aging process

Ou HL, Schumacher B Blood 2017 Nov; PMID: 29141944 Abstract The genome is constantly attacked by genotoxic insults. DNA damage has long been established...   Read More

Systematic analysis of DNA crosslink repair pathways during development and aging in Caenorhabditis elegans

Wilson DM, Rieckher M, Williams AB, Schumacher B Nucleic Acids Res. 2017 Sep;45(16):9467-9480 PMID: 28934497 Abstract DNA interstrand crosslinks (ICLs) are generated by endogenous...   Read More

Multilayered Reprogramming in Response to Persistent DNA Damage in C. elegans

Edifizi D, Nolte H, Babu V, Castells-Roca L, Mueller MM, Brodesser S, Krüger M, Schumacher B Cell Rep 2017 Aug;20(9):2026-2043 PMID: 28854356 Abstract DNA...   Read More

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