MPK-1/ERK pathway regulates DNA damage response during development through DAF-16/FOXO

Bianco JN, Schumacher B Nucleic Acids Res. 2018 Jul;46(12):6129-6139 PMID: 29788264 Abstract Ultraviolet (UV) induces distorting lesions to the DNA that can lead to...   Read More

Maintenance of Proteostasis by P Body-Mediated Regulation of eIF4E Availability during Aging in Caenorhabditis elegans

Rieckher M, Markaki M, Princz A, Schumacher B, Tavernarakis N Cell Rep 2018 Oct;25(1):199-211.e6 PMID: 30282029 Abstract Aging is accompanied by a pervasive collapse...   Read More

The Cdkn1a Mouse as a Tool to Study p53-Mediated Tumor Suppression

Torgovnick A, Heger JM, Liaki V, Isensee J, Schmitt A, Knittel G, Riabinska A, Beleggia F, Laurien L, Leeser U, Jüngst C, Siedek F,...   Read More

Omics Approaches for Identifying Physiological Adaptations to Genome Instability in Aging

Edifizi D, Schumacher B Int J Mol Sci 2017 Nov;18(11) PMID: 29113067 Abstract DNA damage causally contributes to aging and age-related diseases. The declining...   Read More

DNA damage responses and p53 in the aging process

Ou HL, Schumacher B Blood 2017 Nov; PMID: 29141944 Abstract The genome is constantly attacked by genotoxic insults. DNA damage has long been established...   Read More

Systematic analysis of DNA crosslink repair pathways during development and aging in Caenorhabditis elegans

Wilson DM, Rieckher M, Williams AB, Schumacher B Nucleic Acids Res. 2017 Sep;45(16):9467-9480 PMID: 28934497 Abstract DNA interstrand crosslinks (ICLs) are generated by endogenous...   Read More

Multilayered Reprogramming in Response to Persistent DNA Damage in C. elegans

Edifizi D, Nolte H, Babu V, Castells-Roca L, Mueller MM, Brodesser S, Krüger M, Schumacher B Cell Rep 2017 Aug;20(9):2026-2043 PMID: 28854356 Abstract DNA...   Read More

A simple answer to complex questions: Caenorhabditis elegans as an experimental model for examining the DNA damage response and disease genes

Rieckher M, Bujarrabal A, Doll MA, Soltanmohammadi N, Schumacher B J. Cell. Physiol. 2017 May; PMID: 28463453 Abstract The genetic information is constantly challenged...   Read More

E4 ligase-specific ubiquitination hubs coordinate DNA double-strand-break repair and apoptosis

Ackermann L, Schell M, Pokrzywa W, Kevei É, Gartner A, Schumacher B, Hoppe T Nat. Struct. Mol. Biol. 2016 Nov;23(11):995-1002 PMID: 27669035 Abstract Multiple...   Read More

p53 in the DNA-Damage-Repair Process

Williams AB, Schumacher B Cold Spring Harb Perspect Med 2016;6(5) PMID: 27048304 Abstract The cells in the human body are continuously challenged by a...   Read More

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