Genome Instability in Development and Aging: Insights from Nucleotide Excision Repair in Humans, Mice, and Worms

A7 SCHUMACHERpublicationsEdifizi D, Schumacher B; Biomolecules. 2015 Aug 13;5(3):1855-69. doi: 10.3390/biom5031855.

Abstract DNA damage causally contributes to aging and cancer. Congenital defects in nucleotide excision repair (NER) lead to distinct cancer-prone and premature aging syndromes....   Read More

DNA repair mechanisms in cancer development and therapy

A7 SCHUMACHERpublicationsTorgovnick A, Schumacher B; Front Genet. 2015 Apr 23;6:157. doi: 10.3389/fgene.2015.00157. eCollection 2015.

Abstract: DNA damage has been long recognized as causal factor for cancer development. When erroneous DNA repair leads to mutations or chromosomal aberrations affecting...   Read More

Wormpath: searching for molecular interaction networks in Caenorhabditis elegans

A7 SCHUMACHERpublicationsFrommolt P, Schumacher B; Source Code Biol Med. 2015 Apr 2;10:5. doi: 10.1186/s13029-015-0034-6. eCollection 2015.

Abstract Background: High-throughput transcriptional profiling using Next-Generation Sequencing (RNA-Seq) or microarray technology have become standard tools in molecular biology. Successful investigations of gene regulatory...   Read More

Quality control mechanisms in cellular and systemic DNA damage responses

A7 SCHUMACHERpublications Ermolaeva MA, Dakhovnik A, Schumacher B; Ageing Res Rev. 2015 Sep;23(Pt A):3-11. doi: 10.1016/j.arr.2014.12.009. Epub 2015 Jan 3.

Abstract The maintenance of the genome is of pivotal importance for the functional integrity of cells and tissues. The gradual accumulation of DNA damage...   Read More

DAF-16/FOXO and EGL-27/GATA promote developmental growth in response to persistent somatic DNA damage

A7 SCHUMACHERpublicationsMueller MM, Castells-Roca L, Babu V, Ermolaeva MA, Müller RU, Frommolt P, Williams AB, Greiss S, Schneider JI, Benzing T, Schermer B, Schumacher B; Nat Cell Biol. 2014 Dec;16(12):1168-79. doi: 10.1038/ncb3071. Epub 2014 Nov 24.

Abstract Genome maintenance defects cause complex disease phenotypes characterized by developmental failure, cancer susceptibility and premature ageing. It remains poorly understood how DNA damage...   Read More

A C. elegans homolog of the Cockayne syndrome complementation group A gene

A7 SCHUMACHERpublicationsBabu V, Hofmann K, Schumacher B; DNA Repair (Amst). 2014 Dec;24:57-62. doi: 10.1016/j.dnarep.2014.09.011. Epub 2014 Nov 8.

Abstract Cockayne syndrome (CS) is a debilitating and complex disorder that results from inherited mutations in the CS complementation genes A and B, CSA...   Read More

Proteome analysis in the assessment of ageing

A7 SCHUMACHERpublicationsNkuipou-Kenfack E, Koeck T, Mischak H, Pich A, Schanstra JP, Zürbig P, Schumacher B; Ageing Res Rev. 2014 Nov;18:74-85. doi: 10.1016/j.arr.2014.09.002. Epub 2014 Sep 22.

Abstract Based on demographic trends, the societies in many developed countries are facing an increasing number and proportion of people over the age of...   Read More

Insights from the worm: the C. elegans model for innate immunity

A7 SCHUMACHERpublicationsErmolaeva MA, Schumacher B; Semin Immunol. 2014 Aug;26(4):303-9. doi: 10.1016/j.smim.2014.04.005. Epub 2014 May 21.

Abstract The nematode worm Caenorhabditis elegans comprises an ancestral immune system. C. elegans recognizes and responds to viral, bacterial, and fungal infections. Components of...   Read More

Impact of genomic damage and ageing on stem cell function

A7 SCHUMACHERpublicationsBehrens A, van Deursen JM, Rudolph KL, Schumacher B; Nat Cell Biol. 2014 Mar;16(3):201-7. doi: 10.1038/ncb2928.

Abstract Impairment of stem cell function contributes to the progressive deterioration of tissue maintenance and repair with ageing. Evidence is mounting that age-dependent accumulation...   Read More

Systemic DNA damage responses: organismal adaptations to genome instability

A7 SCHUMACHERpublicationsErmolaeva MA, Schumacher B; Trends Genet. 2014 Mar;30(3):95-102. doi: 10.1016/j.tig.2013.12.001. Epub 2014 Jan 15.

Abstract DNA damage checkpoints are important tumor-suppressor mechanisms that halt cell cycle progression to allow time for DNA repair, or induce senescence and apoptosis...   Read More

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