A7 SCHUMACHER

DAF-16/FOXO and EGL-27/GATA promote developmental growth in response to persistent somatic DNA damage

A7 SCHUMACHERpublicationsMueller MM, Castells-Roca L, Babu V, Ermolaeva MA, Müller RU, Frommolt P, Williams AB, Greiss S, Schneider JI, Benzing T, Schermer B, Schumacher B; Nat Cell Biol. 2014 Dec;16(12):1168-79. doi: 10.1038/ncb3071. Epub 2014 Nov 24.

Abstract Genome maintenance defects cause complex disease phenotypes characterized by developmental failure, cancer susceptibility and premature ageing. It remains poorly understood how DNA damage...   Read More

A C. elegans homolog of the Cockayne syndrome complementation group A gene

A7 SCHUMACHERpublicationsBabu V, Hofmann K, Schumacher B; DNA Repair (Amst). 2014 Dec;24:57-62. doi: 10.1016/j.dnarep.2014.09.011. Epub 2014 Nov 8.

Abstract Cockayne syndrome (CS) is a debilitating and complex disorder that results from inherited mutations in the CS complementation genes A and B, CSA...   Read More

Proteome analysis in the assessment of ageing

A7 SCHUMACHERpublicationsNkuipou-Kenfack E, Koeck T, Mischak H, Pich A, Schanstra JP, Zürbig P, Schumacher B; Ageing Res Rev. 2014 Nov;18:74-85. doi: 10.1016/j.arr.2014.09.002. Epub 2014 Sep 22.

Abstract Based on demographic trends, the societies in many developed countries are facing an increasing number and proportion of people over the age of...   Read More

Insights from the worm: the C. elegans model for innate immunity

A7 SCHUMACHERpublicationsErmolaeva MA, Schumacher B; Semin Immunol. 2014 Aug;26(4):303-9. doi: 10.1016/j.smim.2014.04.005. Epub 2014 May 21.

Abstract The nematode worm Caenorhabditis elegans comprises an ancestral immune system. C. elegans recognizes and responds to viral, bacterial, and fungal infections. Components of...   Read More

Impact of genomic damage and ageing on stem cell function

A7 SCHUMACHERpublicationsBehrens A, van Deursen JM, Rudolph KL, Schumacher B; Nat Cell Biol. 2014 Mar;16(3):201-7. doi: 10.1038/ncb2928.

Abstract Impairment of stem cell function contributes to the progressive deterioration of tissue maintenance and repair with ageing. Evidence is mounting that age-dependent accumulation...   Read More

Systemic DNA damage responses: organismal adaptations to genome instability

A7 SCHUMACHERpublicationsErmolaeva MA, Schumacher B; Trends Genet. 2014 Mar;30(3):95-102. doi: 10.1016/j.tig.2013.12.001. Epub 2014 Jan 15.

Abstract DNA damage checkpoints are important tumor-suppressor mechanisms that halt cell cycle progression to allow time for DNA repair, or induce senescence and apoptosis...   Read More

Loss of Caenorhabditis elegans BRCA1 promotes genome stability during replication in smc-5 mutants

A7 SCHUMACHERpublicationsWolters S, Ermolaeva MA, Bickel JS, Fingerhut JM, Khanikar J, Chan RC, Schumacher B; Genetics. 2014 Apr;196(4):985-99. doi: 10.1534/genetics.113.158295. Epub 2014 Jan 14.

Abstract DNA damage by ultraviolet (UV) light poses a risk for mutagenesis and a potential hindrance for cell cycle progression. Cells cope with UV-induced...   Read More

The innate immune system as mediator of systemic DNA damage responses

A7 SCHUMACHERpublicationsErmolaeva M, Schumacher B; Commun Integr Biol. 2013 Nov 13;6(6):e26926. doi: 10.4161/cib.26926. eCollection 2013.

Abstract DNA damage causally contributes to cancer development and tissue degeneration with aging.(1) Cellular DNA damage responses (DDR) mediate cell cycle arrest to allow...   Read More

DNA damage in germ cells induces an innate immune response that triggers systemic stress resistance

A7 SCHUMACHERpublicationsErmolaeva MA, Segref A, Dakhovnik A, Ou HL, Schneider JI, Utermöhlen O, Hoppe T, Schumacher B.

Abstract DNA damage responses have been well characterized with regard to their cell-autonomous checkpoint functions leading to cell cycle arrest, senescence and apoptosis. In...   Read More

Genome maintenance and transcription integrity in aging and disease

A7 SCHUMACHERpublications Wolters, S., Schumacher, B., Front Genet. 2013;4:19. doi: 10.3389/fgene.2013.00019. Epub 2013 Feb 25

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