Loss of Caenorhabditis elegans BRCA1 promotes genome stability during replication in smc-5 mutants

A7 SCHUMACHERpublicationsWolters S, Ermolaeva MA, Bickel JS, Fingerhut JM, Khanikar J, Chan RC, Schumacher B; Genetics. 2014 Apr;196(4):985-99. doi: 10.1534/genetics.113.158295. Epub 2014 Jan 14.

Abstract DNA damage by ultraviolet (UV) light poses a risk for mutagenesis and a potential hindrance for cell cycle progression. Cells cope with UV-induced...   Read More

The innate immune system as mediator of systemic DNA damage responses

A7 SCHUMACHERpublicationsErmolaeva M, Schumacher B; Commun Integr Biol. 2013 Nov 13;6(6):e26926. doi: 10.4161/cib.26926. eCollection 2013.

Abstract DNA damage causally contributes to cancer development and tissue degeneration with aging.(1) Cellular DNA damage responses (DDR) mediate cell cycle arrest to allow...   Read More

DNA damage in germ cells induces an innate immune response that triggers systemic stress resistance

A7 SCHUMACHERpublicationsErmolaeva MA, Segref A, Dakhovnik A, Ou HL, Schneider JI, Utermöhlen O, Hoppe T, Schumacher B.

Abstract DNA damage responses have been well characterized with regard to their cell-autonomous checkpoint functions leading to cell cycle arrest, senescence and apoptosis. In...   Read More

Genome maintenance and transcription integrity in aging and disease

A7 SCHUMACHERpublications Wolters, S., Schumacher, B., Front Genet. 2013;4:19. doi: 10.3389/fgene.2013.00019. Epub 2013 Feb 25

CCR2 recruits an inflammatory macrophage subpopulation critical for angiogenesis in tissue repair

A4 PASPARAKISA7 SCHUMACHERpublicationsLucas, T., Willenborg, S., van Loo, G., Knipper, J., Krieg, T., Haase, I., Brachvogel, B., Nagy, A., Ferrara, N., Pasparakis, M., and Eming, S., Blood. 2012 Jul 19;120(3):613-25. doi: 10.1182/blood-2012-01-403386. Epub 2012 May 10.

Abstract Monocytes/macrophages are critical in orchestrating the tissue-repair response. However, the mechanisms that govern macrophage regenerative activities during the sequential phases of repair are...   Read More

The p53 network: cellular and systemic DNA damage responses in aging and cancer

A7 SCHUMACHERpublications Reinhardt HC, Schumacher B. Trends Genet. 2012 Mar;28(3):128-36.

Abstract Genome instability contributes to cancer development and accelerates age-related pathologies as evidenced by a variety of congenital cancer susceptibility and progeroid syndromes that...   Read More

Sealing the gap between nuclear DNA damage and longevity (2009)

A7 SCHUMACHERB15 HOEIJMAKERSpublications Schumacher B, Hoeijmakers JH, Garinis GA, Mol Cell Endocrinol. 2009 Feb 5;299(1):112-7. Epub 2008 Nov 5.

Abstract: A number of progeroid syndromes with defects in the cellular response to DNA damage suggest that progressive genome instability represents an important aspect...   Read More

Persistent transcription-blocking DNA lesions trigger somatic growth attenuation associated with longevity (2009)

A5 BRÜNING/NIESSENA7 SCHUMACHERB15 HOEIJMAKERSpublications Garinis GA, Uittenboogaard LM, Stachelscheid H, Fousteri M, van Ijcken W, Breit TM, van Steeg H, Mullenders LHF, van der Horst GTJ, Brüning JC, Niessen CM, Hoeijmakers JHJ and Schumacher B, Nature Cell Biol. 2009 May;11(5):604-15.

Abstract: The accumulation of stochastic DNA damage throughout an organism’s lifespan is thought to contribute to ageing. Conversely, ageing seems to be phenotypically reproducible...   Read More

Involvement of global genome repair, transcription coupled repair, and chromatin remodeling in UV DNA damage response changes during development (2010)

A7 SCHUMACHERB15 HOEIJMAKERSpublications Lans H, Marteijn JA, Schumacher B, Hoeijmakers JH, Jansen G, Vermeulen W., PLoS Genet. 2010 May 6;6:e1000941.

Abstract: Nucleotide Excision Repair (NER), which removes a variety of helix-distorting lesions from DNA, is initiated by two distinct DNA damage-sensing mechanisms. Transcription Coupled...   Read More

Next Generation Sequencing of miRNAs – Strategies, Resources and Methods (2010)

A7 SCHUMACHERpublications Motameny S, Wolters S, Nürnberg P, Schumacher B., Genes. 2010; 1(1):70-84.

Abstract: miRNAs constitute a family of small RNA species that have been demonstrated to play a central role in regulating gene expression in many...   Read More

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