Direct activation of chordoblasts by retinoic acid is required for segmented centra mineralization during zebrafish spine development

May 8, 2018A9 HAMMERSCHMIDT

Pogoda HM, Riedl-Quinkertz I, Löhr H, Waxman JS, Dale RM, Topczewski J, Schulte-Merker S, Hammerschmidt M Development 2018 05;145(9) PMID: 29650589 Abstract Zebrafish mutants... Read More

Biallelic CHP1 mutation causes human autosomal recessive ataxia by impairing NHE1 function

January 19, 2018A9 HAMMERSCHMIDT

Mendoza-Ferreira N, Coutelier M, Janzen E, Hosseinibarkooie S, Löhr H, Schneider S, Milbradt J, Karakaya M, Riessland M, Pichlo C, Torres-Benito L, Singleton A,... Read More

A homozygous missense variant in VWA2, encoding an interactor of the Fraser-complex, in a patient with vesicoureteral reflux

January 19, 2018A9 HAMMERSCHMIDT B2 WAGENER/ PAULSSON

van der Ven AT, Kobbe B, Kohl S, Shril S, Pogoda HM, Imhof T, Ityel H, Vivante A, Chen J, Hwang DY, Connaughton DM,... Read More

Dysfunction of the MDM2/p53 axis is linked to premature aging

August 28, 2017A9 HAMMERSCHMIDT

Lessel D, Wu D, Trujillo C, Ramezani T, Lessel I, Alwasiyah MK, Saha B, Hisama FM, Rading K, Goebel I, Schütz P, Speit G,... Read More

The role of Rho kinase (Rock) in re-epithelialization of adult zebrafish skin wounds

November 1, 2016A9 HAMMERSCHMIDT

Richardson R, Hammerschmidt M Small GTPases 2018 05;9(3):230-236 PMID: 27487414 Abstract Complete re-epithelialization of full-thickness skin wounds in adult mammals takes days to complete... Read More

Tumor suppression in basal keratinocytes via dual non-cell-autonomous functions of a Na,K-ATPase beta subunit

June 1, 2016A9 HAMMERSCHMIDT

Hatzold J, Beleggia F, Herzig H, Altmüller J, Nürnberg P, Bloch W, Wollnik B, Hammerschmidt M Elife 2016 May;5 PMID: 27240166 Abstract Molecular pathways... Read More

Re-epithelialization of cutaneous wounds in adult zebrafish uses a combination of mechanisms at play during wound closure in embryonic and adult mammals

April 28, 2016A9 HAMMERSCHMIDT

Richardson R, Metzger M, Knyphausen P, Ramezani T, Slanchev K, Kraus C, Schmelzer E, Hammerschmidt M Development 2016 Apr; PMID: 27122176 Abstract Re-epithelialization of... Read More

Interleukin-4 Receptor α Signaling in Myeloid Cells Controls Collagen Fibril Assembly in Skin Repair

October 22, 2015A9 HAMMERSCHMIDT

Knipper JA, Willenborg S, Brinckmann J, Bloch W, Maaß T, Wagener R, Krieg T, Sutherland T, Munitz A, Rothenberg ME, Niehoff A, Richardson R,... Read More

Protein-Trap Insertional Mutagenesis Uncovers New Genes Involved in Zebrafish Skin Development, Including a Neuregulin 2a-Based ErbB Signaling Pathway Required during Median Fin Fold Morphogenesis

June 25, 2015A9 HAMMERSCHMIDTWestcot SE, Hatzold J, Urban MD, Richetti SK, Skuster KJ, Harm RM, Lopez Cervera R, Umemoto N, McNulty MS, Clark KJ, Hammerschmidt M, Ekker SC; PLoS One. 2015 Jun 25;10(6):e0130688. doi: 10.1371/journal.pone.0130688. eCollection 2015.

Abstract Skin disorders are widespread, but available treatments are limited. A more comprehensive understanding of skin development mechanisms will drive identification of new treatment... Read More

p53 and TAp63 promote keratinocyte proliferation and differentiation in breeding tubercles of the zebrafish

January 9, 2014A9 HAMMERSCHMIDT Fischer B, Metzger M, Richardson R, Knyphausen P, Ramezani T, Franzen R, Schmelzer E, Bloch W, Carney TJ, Hammerschmidt M; PLoS Genet. 2014 Jan;10(1):e1004048. doi: 10.1371/journal.pgen.1004048. Epub 2014 Jan 9.

Abstract p63 is a multi-isoform member of the p53 family of transcription factors. There is compelling genetic evidence that ΔNp63 isoforms are needed for... Read More

A9 HAMMERSCHMIDT