A homozygous missense variant in VWA2, encoding an interactor of the Fraser-complex, in a patient with vesicoureteral reflux

April 17, 2018A9 HAMMERSCHMIDT B2 WAGENER/ PAULSSON publications Uncategorized

van der Ven AT, Kobbe B, Kohl S, Shril S, Pogoda HM, Imhof T, Ityel H, Vivante A, Chen J, Hwang DY, Connaughton DM,... Read More

Tumor suppression in basal keratinocytes via dual non-cell-autonomous functions of a Na,K-ATPase beta subunit

June 1, 2016A9 HAMMERSCHMIDT publications

Hatzold J, Beleggia F, Herzig H, Altmüller J, Nürnberg P, Bloch W, Wollnik B, Hammerschmidt M Elife 2016 May;5 PMID: 27240166 Abstract Molecular pathways... Read More

Re-epithelialization of cutaneous wounds in adult zebrafish uses a combination of mechanisms at play during wound closure in embryonic and adult mammals

April 28, 2016A9 HAMMERSCHMIDT

Richardson R, Metzger M, Knyphausen P, Ramezani T, Slanchev K, Kraus C, Schmelzer E, Hammerschmidt M Development 2016 Apr; PMID: 27122176 Abstract Re-epithelialization of... Read More

Interleukin-4 Receptor α Signaling in Myeloid Cells Controls Collagen Fibril Assembly in Skin Repair

October 22, 2015A9 HAMMERSCHMIDT

Knipper JA, Willenborg S, Brinckmann J, Bloch W, Maaß T, Wagener R, Krieg T, Sutherland T, Munitz A, Rothenberg ME, Niehoff A, Richardson R,... Read More

Protein-Trap Insertional Mutagenesis Uncovers New Genes Involved in Zebrafish Skin Development, Including a Neuregulin 2a-Based ErbB Signaling Pathway Required during Median Fin Fold Morphogenesis

June 25, 2015A9 HAMMERSCHMIDT publicationsWestcot SE, Hatzold J, Urban MD, Richetti SK, Skuster KJ, Harm RM, Lopez Cervera R, Umemoto N, McNulty MS, Clark KJ, Hammerschmidt M, Ekker SC; PLoS One. 2015 Jun 25;10(6):e0130688. doi: 10.1371/journal.pone.0130688. eCollection 2015.

Abstract Skin disorders are widespread, but available treatments are limited. A more comprehensive understanding of skin development mechanisms will drive identification of new treatment... Read More

p53 and TAp63 promote keratinocyte proliferation and differentiation in breeding tubercles of the zebrafish

January 9, 2014A9 HAMMERSCHMIDT publications Fischer B, Metzger M, Richardson R, Knyphausen P, Ramezani T, Franzen R, Schmelzer E, Bloch W, Carney TJ, Hammerschmidt M; PLoS Genet. 2014 Jan;10(1):e1004048. doi: 10.1371/journal.pgen.1004048. Epub 2014 Jan 9.

Abstract p63 is a multi-isoform member of the p53 family of transcription factors. There is compelling genetic evidence that ΔNp63 isoforms are needed for... Read More

Adult zebrafish as a model system for cutaneous wound-healing research

January 16, 2013A9 HAMMERSCHMIDT B7 EMING publicationsRichardson R, Slanchev K, Kraus C, Knyphausen P, Eming S, Hammerschmidt M; J Invest Dermatol. 2013 Jun;133(6):1655-65. doi: 10.1038/jid.2013.16. Epub 2013 Jan 16.

Abstract Upon injury, the skin must quickly regenerate to regain its barrier function. In mammals, wound healing is rapid and scar free during embryogenesis,... Read More

Hemicentin 2 and Fibulin 1 are required for epidermal-dermal junction formation and fin mesenchymal cell migration during zebrafish development

July 16, 2012A9 HAMMERSCHMIDT publicationsFeitosa, N. M., Zhang, J., Carney, T.J., Metzger, M., Korzh, V., Bloch, W. and Hammerschmidt, M., Dev Biol. 2012 Sep 15;369(2):235-48. doi: 10.1016/j.ydbio.2012.06.023. Epub 2012 Jul 6.

Abstract Hemicentin 1 (Hmcn1) and Hemicentin 2 (Hmcn2) belong to the fibulin family of extracellular matrix (ECM) proteins that play pivotal roles during development... Read More

Basement membrane diseases in zebrafish

October 5, 2011A9 HAMMERSCHMIDT publications Feitosa, N., Richardson, R., Bloch, W. and Hammerschmidt, M; Methods Cell Biol. 105, 191-222

Abstract Basement membranes (BMs) are a complex, sheet-like network of specialized extracellular matrix that underlies epithelial cells and surrounds muscle cells. They provide adherence... Read More

Genetic analysis of fin development in zebrafish identifies Furin and Hemicentin1 as potential novel Fraser Syndrome disease genes

August 3, 2010A9 HAMMERSCHMIDT B2 WAGENER/ PAULSSON publications Carney, T. J., Feitosa, N., Sonntag, C., Slanchev, K., Kluger, J., Kiyozumi, D., Gebauer, J., Coffin Talbot, J., Kimmel, C.B., Sekiguchi, K., Wagener, R., Schwarz, R., Ingham, P.I. and Hammerschmidt, M. PLoS Genet. 6, e1000907

Abstract Using forward genetics, we have identified the genes mutated in two classes of zebrafish fin mutants. The mutants of the first class are... Read More

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