Adult zebrafish as a model system for cutaneous wound-healing research

January 16, 2013A9 HAMMERSCHMIDT B7 EMINGRichardson R, Slanchev K, Kraus C, Knyphausen P, Eming S, Hammerschmidt M; J Invest Dermatol. 2013 Jun;133(6):1655-65. doi: 10.1038/jid.2013.16. Epub 2013 Jan 16.

Abstract Upon injury, the skin must quickly regenerate to regain its barrier function. In mammals, wound healing is rapid and scar free during embryogenesis,... Read More

Hemicentin 2 and Fibulin 1 are required for epidermal-dermal junction formation and fin mesenchymal cell migration during zebrafish development

July 16, 2012A9 HAMMERSCHMIDTFeitosa, N. M., Zhang, J., Carney, T.J., Metzger, M., Korzh, V., Bloch, W. and Hammerschmidt, M., Dev Biol. 2012 Sep 15;369(2):235-48. doi: 10.1016/j.ydbio.2012.06.023. Epub 2012 Jul 6.

Abstract Hemicentin 1 (Hmcn1) and Hemicentin 2 (Hmcn2) belong to the fibulin family of extracellular matrix (ECM) proteins that play pivotal roles during development... Read More

Basement membrane diseases in zebrafish

October 5, 2011A9 HAMMERSCHMIDT Feitosa, N., Richardson, R., Bloch, W. and Hammerschmidt, M; Methods Cell Biol. 105, 191-222

Abstract Basement membranes (BMs) are a complex, sheet-like network of specialized extracellular matrix that underlies epithelial cells and surrounds muscle cells. They provide adherence... Read More

Genetic analysis of fin development in zebrafish identifies Furin and Hemicentin1 as potential novel Fraser Syndrome disease genes

August 3, 2010A9 HAMMERSCHMIDT B2 WAGENER/ PAULSSON Carney, T. J., Feitosa, N., Sonntag, C., Slanchev, K., Kluger, J., Kiyozumi, D., Gebauer, J., Coffin Talbot, J., Kimmel, C.B., Sekiguchi, K., Wagener, R., Schwarz, R., Ingham, P.I. and Hammerschmidt, M. PLoS Genet. 6, e1000907

Abstract Using forward genetics, we have identified the genes mutated in two classes of zebrafish fin mutants. The mutants of the first class are... Read More

Zebrafish grainyhead-like1 is a common marker of different non-keratinocyte epidermal cell lineages, which segregate from each other in a Foxi3-dependent manner

August 3, 2010A9 HAMMERSCHMIDT Jänicke, M., Renisch, B. and Hammerschmidt, M. Int. J. Dev. Biol. 54, 837-850.

Abstract Grainyhead/CP2 transcription factor family members are widely conserved among the animal kingdom and have been implicated in different developmental processes. Thus far, nothing... Read More

The epithelial cell adhesion molecule EpCAM is required for epithelial morphogenesis and integrity during zebrafish epiboly and skin development

August 3, 2009A9 HAMMERSCHMIDT Slanchev K., Carney, T. J., Stemmler, M. P., Koschorz, M., Amsterdam, A., Schwarz, H. and Hammerschmidt, M. PLoS Genet. 5, e1000563

Abstract The aberrant expression of the transmembrane protein EpCAM is associated with tumor progression, affecting different cellular processes such as cell-cell adhesion, migration, proliferation,... Read More

Interrelation of immunity and tissue repair or regeneration

July 8, 2009A9 HAMMERSCHMIDT B7 EMING Eming SA, Hammerschmidt M, Krieg T, Roers A. Semin Cell Dev Biol. 2009 Jul;20(5):517-27.

Abstract Although tremendous progress has been achieved in understanding the molecular basis of tissue repair and regeneration in diverse model organisms, the tendency of... Read More

Inactivation of serine protease Matriptase1a by its inhibitor Hai1 is required for epithelial integrity of the zebrafish epidermis

September 10, 2007A9 HAMMERSCHMIDT

Carney TJ, von der Hardt S, Sonntag C, Amsterdam A, Topczewski J, Hopkins N, Hammerschmidt M Development 2007 Oct;134(19):3461-71 PMID: 17728346 Abstract Epithelial integrity... Read More

Crossveinless 2 is an essential positive feedback regulator of Bmp signaling during zebrafish gastrulation

February 10, 2006A9 HAMMERSCHMIDT

Rentzsch F, Zhang J, Kramer C, Sebald W, Hammerschmidt M Development 2006 Mar;133(5):801-11 PMID: 16439480 Abstract Signaling by bone morphogenetic proteins (Bmps) plays a... Read More

Zebrafish DeltaNp63 is a direct target of Bmp signaling and encodes a transcriptional repressor blocking neural specification in the ventral ectoderm

May 17, 2002A9 HAMMERSCHMIDT

Bakkers J, Hild M, Kramer C, Furutani-Seiki M, Hammerschmidt M Dev. Cell 2002 May;2(5):617-27 PMID: 12015969 Abstract Bone morphogenetic proteins (Bmps) promote ventral specification... Read More

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