The pH-Dependent Client Release from the Collagen-Specific Chaperone HSP47 is Triggered by a Tandem Histidine Pair

Oecal S, Socher E, Uthoff M, Ernst C, Zaucke F, Sticht H, Baumann U, Gebauer JM J. Biol. Chem. 2016 Apr; PMID: 27129216 Abstract...   Read More

COMP-assisted collagen secretion – a novel intracellular function required for fibrosis

Schulz JN, Nüchel J, Niehoff A, Bloch W, Schönborn K, Hayashi S, Kamper M, Brinckmann J, Plomann M, Paulsson M, Krieg T, Zaucke F,...   Read More

Doxycycline-induced expression of transgenic human tumor necrosis factor α in adult mice results in psoriasis-like arthritis

Retser E, Schied T, Skryabin BV, Vogl T, Kanczler JM, Hamann N, Niehoff A, Hermann S, Eisenblätter M, Wachsmuth L, Pap T, van Lent...   Read More

Comparative proteomic analysis of normal and collagen IX null mouse cartilage reveals altered extracellular matrix composition and novel components of the collagen IX interactome

Brachvogel B, Zaucke F, Dave K, Norris EL, Stermann J, Dayakli M, Koch M, Gorman JJ, Bateman JF, Wilson R J. Biol. Chem. 2013...   Read More

Different domains in nidogen-1 and nidogen-2 drive basement membrane formation in skin organotypic cocultures

B11 BAUMANN/ZAUCKEB2 WAGENER/ PAULSSONpublicationsBechtel, M., Keller, M., Bloch, W., Sasaki, T., Boukamp, P., Zaucke, F., Paulsson, M., and Nischt, R., FASEB J. 2012 Sep;26(9):3637-48. doi: 10.1096/fj.11-194597. Epub 2012 May 23.

Abstract Nidogen-1 and nidogen-2 are homologous proteins found in all basement membranes (BMs). They show comparable binding activities in vitro and partially redundant functions...   Read More

Molecular basis for the action of the collagen-specific chaperone Hsp47/SERPINH1 and its structure-specific client recognition

Widmer C, Gebauer JM, Brunstein E, Rosenbaum S, Zaucke F, Drögemüller C, Leeb T, Baumann U Proc. Natl. Acad. Sci. U.S.A. 2012 Aug;109(33):13243-7 PMID:...   Read More

Collagen XII and XIV, new partners of cartilage oligomeric matrix protein in the skin extracellular matrix suprastructure

B11 BAUMANN/ZAUCKEB2 WAGENER/ PAULSSONpublicationsAgarwal, P., Zwolanek, D., Keene, D. R., Schulz, J.N., Blumbach, K., Heinegard, D., Zaucke, F., Paulsson, M., Krieg, T., Koch, M., and Eckes, B., J Biol Chem. 2012 Jun 29;287(27):22549-59. doi: 10.1074/jbc.M111.335935. Epub 2012 May 9.

Abstract The tensile and scaffolding properties of skin rely on the complex extracellular matrix (ECM) that surrounds cells, vasculature, nerves, and adnexus structures and...   Read More

A secreted variant of cartilage oligomeric matrix protein carrying a chondrodysplasia-causing mutation (p.H587R) disrupts collagen fibrillogenesis

B11 BAUMANN/ZAUCKEpublicationsHansen, U., Platz, N., Becker, A., Bruckner, P., Paulsson, M., and Zaucke ,F., Arthritis Rheum. 2011 Jan;63(1):159-67. doi: 10.1002/art.30073

Abstract OBJECTIVE: Mutations in human cartilage oligomeric matrix protein (COMP) cause multiple epiphyseal dysplasia or pseudoachondroplasia. Electron microscopic analyses of patient biopsy tissue have...   Read More

A matrilin-3 mutation associated with osteoarthritis does not affect collagen affinity but promotes the formation of wider cartilage collagen fibrils

B11 BAUMANN/ZAUCKEpublications Otten, C., Hansen, U., Talke, A., Wagener, R., Paulsson, M., and Zaucke, F., Hum Mutat. 2010 Mar;31(3):254-63. doi: 10.1002/humu.21182

Abstract Mutations in matrilin-3 have been associated with common skeletal diseases like osteoarthritis as well as with the rare chondrodysplasias MED and SEMD. We...   Read More

The crystal structure of apo-FtsH reveals domain movements necessary for substrate unfolding and translocation

B11 BAUMANN/ZAUCKEpublicationsBieniossek, C., Niederhauser, B., and Baumann, U., Proc Natl Acad Sci U S A. 2009 Dec 22;106(51):21579-84. doi: 10.1073/pnas.0910708106. Epub 2009 Dec 2.

Abstract The hexameric membrane-spanning ATP-dependent metalloprotease FtsH is universally conserved in eubacteria, mitochondria, and chloroplasts, where it fulfills key functions in quality control and...   Read More

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