B11 BAUMANN/ZAUCKE

Combined role of type IX collagen and cartilage oligomeric matrix protein in cartilage matrix assembly: cartilage oligomeric matrix protein counteracts type IX collagen-induced limitation of cartilage collagen fibril growth in mouse chondrocyte cultures

Blumbach K, Bastiaansen-Jenniskens YM, DeGroot J, Paulsson M, van Osch GJ, Zaucke F Arthritis Rheum. 2009 Dec;60(12):3676-85 PMID: 19950300 Abstract OBJECTIVE: Defects in the...   Read More

A missense mutation in the SERPINH1 gene in Dachshunds with osteogenesis imperfecta

B11 BAUMANN/ZAUCKEpublicationsDrögemüller, C., Becker, D., Brunner, A., Haase, B., Kircher, P., Seeliger, F., Fehr, M., Baumann, U., Lindblad-Toh, K., and Leeb, T., PLoS Genet. 2009 Jul;5(7):e1000579. doi: 10.1371/journal.pgen.1000579. Epub 2009 Jul 24.

Abstract Osteogenesis imperfecta (OI) is a hereditary disease occurring in humans and dogs. It is characterized by extremely fragile bones and teeth. Most human...   Read More

A calcium-gated lid and a large beta-roll sandwich are revealed by the crystal structure of extracellular lipase from Serratia marcescens (2007)

B11 BAUMANN/ZAUCKEpublicationsMeier, R., Drepper, T., Svensson, V.E., Jaeger, K-E. and Baumann, U., J Biol Chem. 2007 Oct 26;282(43):31477-83. Epub 2007 Aug 28.

Abstract Lipase LipA from Serratia marcescens is a 613-amino acid enzyme belonging to family I.3 of lipolytic enzymes that has an important biotechnological application...   Read More

The molecular architecture of the metalloprotease FtsH

B11 BAUMANN/ZAUCKEpublicationsBieniossek, C., Schalch, T., Bumann, M., Meister, M., Meier, R., and Baumann, U., Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3066-71. Epub 2006 Feb 16.

Abstract   The ATP-dependent integral membrane protease FtsH is universally conserved in bacteria. Orthologs exist in chloroplasts and mitochondria, where in humans the loss...   Read More

Characterization of recombinant amino-terminal NC4 domain of human collagen IX: interaction with glycosaminoglycans and cartilage oligomeric matrix protein

B11 BAUMANN/ZAUCKEpublicationsPihlajamaa, T., Lankinen, H., Ylöstalo, J., Valmu, L., Jäälinoja, J., Zaucke, F., Spitznagel, L., Gösling, S., Puustinen, A., Mörgelin, M., Peränen, J., Maurer, P., Ala-Kokko, L., and Kilpeläinen, I., J Biol Chem. 2004 Jun 4;279(23):24265-73. Epub 2004 Mar 26.

Abstract The N-terminal NC4 domain of collagen IX is a globular structure projecting away from the surface of the cartilage collagen fibril. Several interactions...   Read More

Characterization of a pseudoachondroplasia-associated mutation (His587–>Arg) in the C-terminal, collagen-binding domain of cartilage oligomeric matrix protein (COMP)

B11 BAUMANN/ZAUCKEpublications Spitznagel, L., Nitsche, D.P., Paulsson, M., Maurer, P., and Zaucke, F., Biochem J. 2004 Jan 15;377(Pt 2):479-87.

Abstract We have introduced a pseudoachondroplasia-associated mutation (His(587)–>Arg) into the C-terminal collagen-binding domain of COMP (cartilage oligomeric matrix protein) and recombinantly expressed the full-length...   Read More

Pseudoachondroplasia is caused through both intra- and extracellular pathogenic pathways

B11 BAUMANN/ZAUCKEpublicationsDinser, R., Zaucke, F., Kreppel, F., Hultenby, K., Kochanek, S., Paulsson, M., Maurer, P,. J Clin Invest. 2002 Aug;110(4):505-13.

Abstract Pseudoachondroplasia is a dominantly inherited chondrodysplasia associated with mutations in cartilage oligomeric matrix protein (COMP). Investigations into the pathogenesis of pseudoachondroplasia are hampered...   Read More

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