The crystal structure of apo-FtsH reveals domain movements necessary for substrate unfolding and translocation

B11 BAUMANN/ZAUCKEpublicationsBieniossek, C., Niederhauser, B., and Baumann, U., Proc Natl Acad Sci U S A. 2009 Dec 22;106(51):21579-84. doi: 10.1073/pnas.0910708106. Epub 2009 Dec 2.

Abstract The hexameric membrane-spanning ATP-dependent metalloprotease FtsH is universally conserved in eubacteria, mitochondria, and chloroplasts, where it fulfills key functions in quality control and...   Read More

Combined role of type IX collagen and cartilage oligomeric matrix protein in cartilage matrix assembly: cartilage oligomeric matrix protein counteracts type IX collagen-induced limitation of cartilage collagen fibril growth in mouse chondrocyte cultures

Blumbach K, Bastiaansen-Jenniskens YM, DeGroot J, Paulsson M, van Osch GJ, Zaucke F Arthritis Rheum. 2009 Dec;60(12):3676-85 PMID: 19950300 Abstract OBJECTIVE: Defects in the...   Read More

A missense mutation in the SERPINH1 gene in Dachshunds with osteogenesis imperfecta

B11 BAUMANN/ZAUCKEpublicationsDrögemüller, C., Becker, D., Brunner, A., Haase, B., Kircher, P., Seeliger, F., Fehr, M., Baumann, U., Lindblad-Toh, K., and Leeb, T., PLoS Genet. 2009 Jul;5(7):e1000579. doi: 10.1371/journal.pgen.1000579. Epub 2009 Jul 24.

Abstract Osteogenesis imperfecta (OI) is a hereditary disease occurring in humans and dogs. It is characterized by extremely fragile bones and teeth. Most human...   Read More

A calcium-gated lid and a large beta-roll sandwich are revealed by the crystal structure of extracellular lipase from Serratia marcescens (2007)

B11 BAUMANN/ZAUCKEpublicationsMeier, R., Drepper, T., Svensson, V.E., Jaeger, K-E. and Baumann, U., J Biol Chem. 2007 Oct 26;282(43):31477-83. Epub 2007 Aug 28.

Abstract Lipase LipA from Serratia marcescens is a 613-amino acid enzyme belonging to family I.3 of lipolytic enzymes that has an important biotechnological application...   Read More

The molecular architecture of the metalloprotease FtsH

B11 BAUMANN/ZAUCKEpublicationsBieniossek, C., Schalch, T., Bumann, M., Meister, M., Meier, R., and Baumann, U., Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3066-71. Epub 2006 Feb 16.

Abstract   The ATP-dependent integral membrane protease FtsH is universally conserved in bacteria. Orthologs exist in chloroplasts and mitochondria, where in humans the loss...   Read More

Characterization of recombinant amino-terminal NC4 domain of human collagen IX: interaction with glycosaminoglycans and cartilage oligomeric matrix protein

B11 BAUMANN/ZAUCKEpublicationsPihlajamaa, T., Lankinen, H., Ylöstalo, J., Valmu, L., Jäälinoja, J., Zaucke, F., Spitznagel, L., Gösling, S., Puustinen, A., Mörgelin, M., Peränen, J., Maurer, P., Ala-Kokko, L., and Kilpeläinen, I., J Biol Chem. 2004 Jun 4;279(23):24265-73. Epub 2004 Mar 26.

Abstract The N-terminal NC4 domain of collagen IX is a globular structure projecting away from the surface of the cartilage collagen fibril. Several interactions...   Read More

Characterization of a pseudoachondroplasia-associated mutation (His587–>Arg) in the C-terminal, collagen-binding domain of cartilage oligomeric matrix protein (COMP)

B11 BAUMANN/ZAUCKEpublications Spitznagel, L., Nitsche, D.P., Paulsson, M., Maurer, P., and Zaucke, F., Biochem J. 2004 Jan 15;377(Pt 2):479-87.

Abstract We have introduced a pseudoachondroplasia-associated mutation (His(587)–>Arg) into the C-terminal collagen-binding domain of COMP (cartilage oligomeric matrix protein) and recombinantly expressed the full-length...   Read More

Pseudoachondroplasia is caused through both intra- and extracellular pathogenic pathways

B11 BAUMANN/ZAUCKEpublicationsDinser, R., Zaucke, F., Kreppel, F., Hultenby, K., Kochanek, S., Paulsson, M., Maurer, P,. J Clin Invest. 2002 Aug;110(4):505-13.

Abstract Pseudoachondroplasia is a dominantly inherited chondrodysplasia associated with mutations in cartilage oligomeric matrix protein (COMP). Investigations into the pathogenesis of pseudoachondroplasia are hampered...   Read More

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