B12 SENGLE

Targeting of EMILIN-1 and EMILIN-2 to Fibrillin Microfibrils Facilitates their Incorporation into the Extracellular Matrix

Schiavinato A, Keene DR, Wohl AP, Corallo D, Colombatti A, Wagener R, Paulsson M, Bonaldo P, Sengle G J. Invest. Dermatol. 2016 Mar; PMID:...   Read More

Extracellular Regulation of Bone Morphogenetic Protein Activity by the Microfibril Component Fibrillin-1

Wohl AP, Troilo H, Collins RF, Baldock C, Sengle G J. Biol. Chem. 2016 Apr; PMID: 27059954 Abstract Since the discovery of bone morphogenetic...   Read More

Structural characterization of twisted gastrulation provides insights into opposing functions on the BMP signalling pathway

Troilo H, Barrett AL, Zuk AV, Lockhart-Cairns MP, Wohl AP, Bayley CP, Dajani R, Tunnicliffe RB, Green L, Jowitt TA, Sengle G, Baldock C...   Read More

Characterization of Microfibrillar-associated Protein 4 (MFAP4) as a Tropoelastin- and Fibrillin-binding Protein Involved in Elastic Fiber Formation

Pilecki B, Holm AT, Schlosser A, Moeller JB, Wohl AP, Zuk AV, Heumüller SE, Wallis R, Moestrup SK, Sengle G, Holmskov U, Sorensen GL...   Read More

The role of chordin fragments generated by partial tolloid cleavage in regulating BMP activity

Troilo H, Barrett AL, Wohl AP, Jowitt TA, Collins RF, Bayley CP, Zuk AV, Sengle G, Baldock C Biochem. Soc. Trans. 2015 Oct;43(5):795-800 PMID:...   Read More

The fibrillin microfibril scaffold: A niche for growth factors and mechanosensation?

Sengle G, Sakai LY Matrix Biol. 2015 Sep;47:3-12 PMID: 25957947 Abstract The fibrillins, large extracellular matrix molecules, are polymerized to form „microfibrils.“ The fibrillin...   Read More

Abnormal Activation of BMP Signaling Causes Myopathy in Fbn2 Null Mice

Sengle G, Carlberg V, Tufa SF, Charbonneau NL, Smaldone S, Carlson EJ, Ramirez F, Keene DR, Sakai LY PLoS Genet. 2015 Jun;11(6):e1005340 PMID: 26114882...   Read More

Modeling autosomal recessive cutis laxa type 1C in mice reveals distinct functions for Ltbp-4 isoforms

B12 SENGLEpublicationsBultmann-Mellin I, Conradi A, Maul AC, Dinger K, Wempe F, Wohl AP, Imhof T, Wunderlich FT, Bunck AC, Nakamura T, Koli K, Bloch W, Ghanem A, Heinz A, von Melchner H, Sengle G, Sterner-Kock A; Dis Model Mech. 2015 Apr;8(4):403-15. doi: 10.1242/dmm.018960. Epub 2015 Feb 20.

Abstract Recent studies have revealed an important role for LTBP-4 in elastogenesis. Its mutational inactivation in humans causes autosomal recessive cutis laxa type 1C...   Read More

Nanoscale structure of the BMP antagonist chordin supports cooperative BMP binding

B12 SENGLEpublicationsTroilo H, Zuk AV, Tunnicliffe RB, Wohl AP, Berry R, Collins RF, Jowitt TA, Sengle G, Baldock C; Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):13063-8. doi: 10.1073/pnas.1404166111. Epub 2014 Aug 25.

Abstract Bone morphogenetic proteins (BMPs) orchestrate key cellular events, such as proliferation and differentiation, in development and homeostasis. Extracellular antagonists, such as chordin, are...   Read More

Molecular and cellular basis of scleroderma

Eckes B, Moinzadeh P, Sengle G, Hunzelmann N, Krieg T J. Mol. Med. 2014 Sep;92(9):913-24 PMID: 25030650 Abstract Systemic sclerosis (scleroderma) is a chronic...   Read More

  • Upcoming Events

    1. 4th PhD student and Postdoc Minisymposium

      Juli 7 @ 3:00 pm - 5:00 pm
    2. 4th German-French DNA Repair Meeting Cologne 2017

      September 21 - September 23
    3. 33. Klenk Symposium 2017 in Molecular Medicine

      Oktober 15 - Oktober 17

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