TGFB1 is secreted through an unconventional pathway dependent on the autophagic machinery and cytoskeletal regulators

Nüchel J, Ghatak S, Zuk AV, Illerhaus A, Mörgelin M, Schönborn K, Blumbach K, Wickström SA, Krieg T, Sengle G, Plomann M, Eckes B...   Read More

Fibulin-4 deposition requires EMILIN-1 in the extracellular matrix of osteoblasts

Schiavinato A, Keene DR, Imhof T, Doliana R, Sasaki T, Sengle G Sci Rep 2017 Jul;7(1):5526 PMID: 28717224 Abstract Tissue microenvironments formed by extracellular...   Read More

Raman microspectroscopy as a diagnostic tool for the non-invasive analysis of fibrillin-1 deficiency in the skin and in the in vitro skin models

Brauchle E, Bauer H, Fernes P, Zuk A, Schenke-Layland K, Sengle G Acta Biomater 2017 Apr;52:41-48 PMID: 27956365 Abstract Fibrillin microfibrils and elastic fibers...   Read More

Cutis laxa acquisita: novel insights into impaired elastic fibre regeneration

Gkogkolou P, Hildebrandt K, Broekaert S, Metze D, Sengle G, Böhm M Br. J. Dermatol. 2017 03;176(3):832-835 PMID: 27873303 Abstract

Function of Ltbp-4L and fibulin-4 in survival and elastogenesis in mice

Bultmann-Mellin I, Essers J, van Heijingen PM, von Melchner H, Sengle G, Sterner-Kock A Dis Model Mech 2016 11;9(11):1367-1374 PMID: 27585882 Abstract LTBP-4L and...   Read More

Targeting of EMILIN-1 and EMILIN-2 to Fibrillin Microfibrils Facilitates their Incorporation into the Extracellular Matrix

Schiavinato A, Keene DR, Wohl AP, Corallo D, Colombatti A, Wagener R, Paulsson M, Bonaldo P, Sengle G J. Invest. Dermatol. 2016 Mar; PMID:...   Read More

Extracellular Regulation of Bone Morphogenetic Protein Activity by the Microfibril Component Fibrillin-1

Wohl AP, Troilo H, Collins RF, Baldock C, Sengle G J. Biol. Chem. 2016 Apr; PMID: 27059954 Abstract Since the discovery of bone morphogenetic...   Read More

Structural characterization of twisted gastrulation provides insights into opposing functions on the BMP signalling pathway

Troilo H, Barrett AL, Zuk AV, Lockhart-Cairns MP, Wohl AP, Bayley CP, Dajani R, Tunnicliffe RB, Green L, Jowitt TA, Sengle G, Baldock C...   Read More

Characterization of Microfibrillar-associated Protein 4 (MFAP4) as a Tropoelastin- and Fibrillin-binding Protein Involved in Elastic Fiber Formation

Pilecki B, Holm AT, Schlosser A, Moeller JB, Wohl AP, Zuk AV, Heumüller SE, Wallis R, Moestrup SK, Sengle G, Holmskov U, Sorensen GL...   Read More

The role of chordin fragments generated by partial tolloid cleavage in regulating BMP activity

Troilo H, Barrett AL, Wohl AP, Jowitt TA, Collins RF, Bayley CP, Zuk AV, Sengle G, Baldock C Biochem. Soc. Trans. 2015 Oct;43(5):795-800 PMID:...   Read More

  • Upcoming Events

    1. International Investigative Dermatology 2018

      Mai 16 - Mai 18
    2. Women in Science and Society with Sarah Millar

      Juni 19 @ 1:30 pm - 6:00 pm
    3. 9th PhD student and Postdoc Retreat

      August 22 - August 23
    4. 2nd SFB 829 Connector Meeting

      August 31 @ 3:00 pm - 5:30 pm
    5. International Symposium „Molecular Mechanisms regulating Skin Homeostasis“

      November 12 - November 14

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