B12 SENGLE

Fibrillin microfibrils and proteases, key integrators of fibrotic pathways

Zigrino P, Sengle G Adv. Drug Deliv. Rev. 2018 Apr; PMID: 29709492 Abstract Supramolecular networks composed of multi-domain ECM proteins represent intricate cellular microenvironments...   Read More

Odd skipped-related 1 identifies a population of embryonic fibro-adipogenic progenitors regulating myogenesis during limb development

Vallecillo-García P, Orgeur M, Vom Hofe-Schneider S, Stumm J, Kappert V, Ibrahim DM, Börno ST, Hayashi S, Relaix F, Hildebrandt K, Sengle G, Koch...   Read More

TGFB1 is secreted through an unconventional pathway dependent on the autophagic machinery and cytoskeletal regulators

Nüchel J, Ghatak S, Zuk AV, Illerhaus A, Mörgelin M, Schönborn K, Blumbach K, Wickström SA, Krieg T, Sengle G, Plomann M, Eckes B...   Read More

Fibulin-4 deposition requires EMILIN-1 in the extracellular matrix of osteoblasts

Schiavinato A, Keene DR, Imhof T, Doliana R, Sasaki T, Sengle G Sci Rep 2017 Jul;7(1):5526 PMID: 28717224 Abstract Tissue microenvironments formed by extracellular...   Read More

Raman microspectroscopy as a diagnostic tool for the non-invasive analysis of fibrillin-1 deficiency in the skin and in the in vitro skin models

Brauchle E, Bauer H, Fernes P, Zuk A, Schenke-Layland K, Sengle G Acta Biomater 2017 Apr;52:41-48 PMID: 27956365 Abstract Fibrillin microfibrils and elastic fibers...   Read More

Cutis laxa acquisita: novel insights into impaired elastic fibre regeneration

Gkogkolou P, Hildebrandt K, Broekaert S, Metze D, Sengle G, Böhm M Br. J. Dermatol. 2017 03;176(3):832-835 PMID: 27873303 Abstract

Function of Ltbp-4L and fibulin-4 in survival and elastogenesis in mice

Bultmann-Mellin I, Essers J, van Heijingen PM, von Melchner H, Sengle G, Sterner-Kock A Dis Model Mech 2016 11;9(11):1367-1374 PMID: 27585882 Abstract LTBP-4L and...   Read More

Targeting of EMILIN-1 and EMILIN-2 to Fibrillin Microfibrils Facilitates their Incorporation into the Extracellular Matrix

Schiavinato A, Keene DR, Wohl AP, Corallo D, Colombatti A, Wagener R, Paulsson M, Bonaldo P, Sengle G J. Invest. Dermatol. 2016 Mar; PMID:...   Read More

Extracellular Regulation of Bone Morphogenetic Protein Activity by the Microfibril Component Fibrillin-1

Wohl AP, Troilo H, Collins RF, Baldock C, Sengle G J. Biol. Chem. 2016 Apr; PMID: 27059954 Abstract Since the discovery of bone morphogenetic...   Read More

Structural characterization of twisted gastrulation provides insights into opposing functions on the BMP signalling pathway

Troilo H, Barrett AL, Zuk AV, Lockhart-Cairns MP, Wohl AP, Bayley CP, Dajani R, Tunnicliffe RB, Green L, Jowitt TA, Sengle G, Baldock C...   Read More

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