Vitamin D is required for IFN-gamma-mediated antimicrobial activity of human macrophages

B13 FABRIpublicationsFabri, M., Stenger, S., Shin, D.M., Yuk, J.M., Liu, P.T., Realegeno, S., Lee, H.M., Krutzik, S.R., Schenk, M., Sieling, P.A., et al., Sci Transl Med. 2011 Oct 12;3(104):104ra102. doi: 10.1126/scitranslmed.3003045.

Abstract Control of tuberculosis worldwide depends on our understanding of human immune mechanisms, which combat the infection. Acquired T cell responses are critical for...   Read More

Role of autophagy in the host response to microbial infection and potential for therapy

B13 FABRIpublicationsFabri, M., Realegeno, S.E., Jo, E.K., and Modlin, R.L., Curr Opin Immunol. 2011 Feb;23(1):65-70. doi: 10.1016/j.coi.2010.10.010. Epub 2010 Nov 9

Abstract   There is compelling evidence demonstrating a key role for autophagy in host defense against microbial infections. Induction and regulation of autophagy involves...   Read More

T-cell cytokines differentially control human monocyte antimicrobial responses by regulating vitamin D metabolism

B13 FABRIpublications Edfeldt, K., Liu, P.T., Chun, R., Fabri, M., Schenk, M., Wheelwright, M., Keegan, C., Krutzik, S.R., Adams, J.S., Hewison, M., et al., Proc Natl Acad Sci U S A. 2010 Dec 28;107(52):22593-8. doi: 10.1073/pnas.1011624108. Epub 2010 Dec 13.

Abstract We investigated the mechanisms by which T-cell cytokines are able to influence the Toll-like receptor (TLR)-induced, vitamin D-dependent antimicrobial pathway in human monocytes....   Read More

A vitamin for autophagy

B13 FABRIpublicationsFabri, M., and Modlin, R.L., Cell Host Microbe. 2009 Sep 17;6(3):201-3. doi: 10.1016/j.chom.2009.08.008.

Abstract Recent discoveries have revealed the importance of the vitamin D-dependent generation of antimicrobial peptides in human host defense against Mycobacterium tuberculosis. Now, Yuk...   Read More

Conserved mycobacterial lipoglycoproteins activate TLR2 but also require glycosylation for MHC class II-restricted T cell activation

B13 FABRIpublicationsSieling, P.A., Hill, P.J., Dobos, K.M., Brookman, K., Kuhlman, A.M., Fabri, M., Krutzik, S.R., Rea, T.H., Heaslip, D.G., Belisle, J.T., et al., J Immunol. 2008 May 1;180(9):5833-42.

Abstract CD4(+) T cell clones derived from a leprosy lesion and patient blood were used to monitor the isolation and identification of an Ag...   Read More

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