B13 FABRI

T-cell cytokines differentially control human monocyte antimicrobial responses by regulating vitamin D metabolism

B13 FABRIpublications Edfeldt, K., Liu, P.T., Chun, R., Fabri, M., Schenk, M., Wheelwright, M., Keegan, C., Krutzik, S.R., Adams, J.S., Hewison, M., et al., Proc Natl Acad Sci U S A. 2010 Dec 28;107(52):22593-8. doi: 10.1073/pnas.1011624108. Epub 2010 Dec 13.

Abstract We investigated the mechanisms by which T-cell cytokines are able to influence the Toll-like receptor (TLR)-induced, vitamin D-dependent antimicrobial pathway in human monocytes....   Read More

A vitamin for autophagy

B13 FABRIpublicationsFabri, M., and Modlin, R.L., Cell Host Microbe. 2009 Sep 17;6(3):201-3. doi: 10.1016/j.chom.2009.08.008.

Abstract Recent discoveries have revealed the importance of the vitamin D-dependent generation of antimicrobial peptides in human host defense against Mycobacterium tuberculosis. Now, Yuk...   Read More

Conserved mycobacterial lipoglycoproteins activate TLR2 but also require glycosylation for MHC class II-restricted T cell activation

B13 FABRIpublicationsSieling, P.A., Hill, P.J., Dobos, K.M., Brookman, K., Kuhlman, A.M., Fabri, M., Krutzik, S.R., Rea, T.H., Heaslip, D.G., Belisle, J.T., et al., J Immunol. 2008 May 1;180(9):5833-42.

Abstract CD4(+) T cell clones derived from a leprosy lesion and patient blood were used to monitor the isolation and identification of an Ag...   Read More

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