B13 FABRI

LL37:DNA complexes provide antimicrobial activity against intracellular bacteria in human macrophages

Stephan A, Batinica M, Steiger J, Hartmann P, Zaucke F, Bloch W, Fabri M Immunology 2016 May; PMID: 27177697 Abstract As part of the...   Read More

Vitamin D regulates cytokine patterns secreted by dendritic cells to promote differentiation of IL-22-producing T cells

B13 FABRISommer A, Fabri M; PLoS One. 2015 Jun 24;10(6):e0130395. doi: 10.1371/journal.pone.0130395. eCollection 2015.

Abstract One central mechanism, by which vitamin D regulates human immune responses, is the direct modulation of dendritic cells (DCs). However, the effect of...   Read More

Vitamin D every day to keep the infection away?

Kroner Jde C, Sommer A, Fabri M Nutrients 2015 Jun;7(6):4170-88 PMID: 26035244 Abstract Within the last decade, vitamin D has emerged as a central...   Read More

Vitamin D controls apoptosis and proliferation of cutaneous T-cell lymphoma cells

B13 FABRIMrotzek C, Felcht M, Sommer A, Schrader A, Klemke CD, Herling M, Schlaak M, Fabri M; Exp Dermatol. 2015 May 2. doi: 10.1111/exd.12746. [Epub ahead of print]

Vitamin D-dependent induction of cathelicidin in human macrophages results in cytotoxicity against high-grade B cell lymphoma

B13 FABRIBruns H, Büttner M, Fabri M, Mougiakakos D, Bittenbring JT, Hoffmann MH, Beier F, Pasemann S, Jitschin R, Hofmann AD, Neumann F, Daniel C, Maurberger A, Kempkes B, Amann K, Mackensen A, Gerbitz A; Sci Transl Med. 2015 Apr 8;7(282):282ra47. doi: 10.1126/scitranslmed.aaa3230.

Abstract Infiltration by macrophages represents a characteristic morphological hallmark in high-grade lymphatic malignancies such as Burkitt’s lymphoma (BL). Although macrophages can, in principle, target...   Read More

The NET, the trap and the pathogen: neutrophil extracellular traps in cutaneous immunity

Stephan A, Fabri M Exp. Dermatol. 2015 Mar;24(3):161-6 PMID: 25421224 Abstract Neutrophil extracellular traps (NETs), large chromatin structures casted with various proteins, are externalized...   Read More

CD40 ligand and interferon-γ induce an antimicrobial response against Mycobacterium tuberculosis in human monocytes

B13 FABRIKlug-Micu GM, Stenger S, Sommer A, Liu PT, Krutzik SR, Modlin RL, Fabri M; Immunology. 2013 May;139(1):121-8. doi: 10.1111/imm.12062.

Abstract The ability of T cells to activate antimicrobial pathways in infected macrophages is essential to host defence against many intracellular pathogens. Here, we...   Read More

Vitamin D is required for IFN-gamma-mediated antimicrobial activity of human macrophages

B13 FABRIFabri, M., Stenger, S., Shin, D.M., Yuk, J.M., Liu, P.T., Realegeno, S., Lee, H.M., Krutzik, S.R., Schenk, M., Sieling, P.A., et al., Sci Transl Med. 2011 Oct 12;3(104):104ra102. doi: 10.1126/scitranslmed.3003045.

Abstract Control of tuberculosis worldwide depends on our understanding of human immune mechanisms, which combat the infection. Acquired T cell responses are critical for...   Read More

Role of autophagy in the host response to microbial infection and potential for therapy

B13 FABRIFabri, M., Realegeno, S.E., Jo, E.K., and Modlin, R.L., Curr Opin Immunol. 2011 Feb;23(1):65-70. doi: 10.1016/j.coi.2010.10.010. Epub 2010 Nov 9

Abstract   There is compelling evidence demonstrating a key role for autophagy in host defense against microbial infections. Induction and regulation of autophagy involves...   Read More

T-cell cytokines differentially control human monocyte antimicrobial responses by regulating vitamin D metabolism

B13 FABRI Edfeldt, K., Liu, P.T., Chun, R., Fabri, M., Schenk, M., Wheelwright, M., Keegan, C., Krutzik, S.R., Adams, J.S., Hewison, M., et al., Proc Natl Acad Sci U S A. 2010 Dec 28;107(52):22593-8. doi: 10.1073/pnas.1011624108. Epub 2010 Dec 13.

Abstract We investigated the mechanisms by which T-cell cytokines are able to influence the Toll-like receptor (TLR)-induced, vitamin D-dependent antimicrobial pathway in human monocytes....   Read More

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