Restricted diet delays accelerated ageing and genomic stress in DNA-repair-deficient mice

September 15, 2016B15 HOEIJMAKERS publications

Vermeij WP, Dollé ME, Reiling E, Jaarsma D, Payan-Gomez C, Bombardieri CR, Wu H, Roks AJ, Botter SM, van der Eerden BC, Youssef SA,... Read More

Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis

February 25, 2016B15 HOEIJMAKERS publications

Matsumura H, Mohri Y, Binh NT, Morinaga H, Fukuda M, Ito M, Kurata S, Hoeijmakers J, Nishimura EK Science 2016 Feb;351(6273):aad4395 PMID: 26912707 Abstract... Read More

Understanding nucleotide excision repair and its roles in cancer and ageing

June 23, 2014B15 HOEIJMAKERS publications

Marteijn JA, Lans H, Vermeulen W, Hoeijmakers JH Nat. Rev. Mol. Cell Biol. 2014 Jul;15(7):465-81 PMID: 24954209 Abstract Nucleotide excision repair (NER) eliminates various... Read More

UV-sensitive syndrome protein UVSSA recruits USP7 to regulate transcription-coupled repair

June 7, 2012B15 HOEIJMAKERS publications

Schwertman P, Lagarou A, Dekkers DH, Raams A, van der Hoek AC, Laffeber C, Hoeijmakers JH, Demmers JA, Fousteri M, Vermeulen W, Marteijn JA... Read More

Sealing the gap between nuclear DNA damage and longevity (2009)

August 24, 2011A7 SCHUMACHER B15 HOEIJMAKERS publications Schumacher B, Hoeijmakers JH, Garinis GA, Mol Cell Endocrinol. 2009 Feb 5;299(1):112-7. Epub 2008 Nov 5.

Abstract: A number of progeroid syndromes with defects in the cellular response to DNA damage suggest that progressive genome instability represents an important aspect... Read More

Persistent transcription-blocking DNA lesions trigger somatic growth attenuation associated with longevity (2009)

August 24, 2011A5 BRÜNING/NIESSEN A7 SCHUMACHER B15 HOEIJMAKERS publications Garinis GA, Uittenboogaard LM, Stachelscheid H, Fousteri M, van Ijcken W, Breit TM, van Steeg H, Mullenders LHF, van der Horst GTJ, Brüning JC, Niessen CM, Hoeijmakers JHJ and Schumacher B, Nature Cell Biol. 2009 May;11(5):604-15.

Abstract: The accumulation of stochastic DNA damage throughout an organism’s lifespan is thought to contribute to ageing. Conversely, ageing seems to be phenotypically reproducible... Read More

Involvement of global genome repair, transcription coupled repair, and chromatin remodeling in UV DNA damage response changes during development (2010)

August 24, 2011A7 SCHUMACHER B15 HOEIJMAKERS publications Lans H, Marteijn JA, Schumacher B, Hoeijmakers JH, Jansen G, Vermeulen W., PLoS Genet. 2010 May 6;6:e1000941.

Abstract: Nucleotide Excision Repair (NER), which removes a variety of helix-distorting lesions from DNA, is initiated by two distinct DNA damage-sensing mechanisms. Transcription Coupled... Read More

Persistent transcription-blocking DNA lesions trigger somatic growth attenuation associated with longevity

May 3, 2009A5 BRÜNING/NIESSEN A7 SCHUMACHER B15 HOEIJMAKERS publications Garinis, G.A., Uittenboogaard L.M., Stachelscheid H., van Ijcken, W. , Breit T.M., van Steeg H., Mullenders L.H.F., van der Horst G.T.J., Brüning J.C., Niessen C.M., Hoeijmakers J.H.J, and Schumacher B. Nat. Cell Biol.. 11:604-15.

Abstract The accumulation of stochastic DNA damage throughout an organism’s lifespan is thought to contribute to ageing. Conversely, ageing seems to be phenotypically reproducible... Read More

B15 HOEIJMAKERS