B3 ECKES KRIEG

Role of Integrins α1β1 and α2β1 in Wound and Tumor Angiogenesis in Mice

Ghatak S, Niland S, Schulz JN, Wang F, Eble JA, Leitges M, Mauch C, Krieg T, Zigrino P, Eckes B Am. J. Pathol. 2016...   Read More

Laminin α5 in the keratinocyte basement membrane is required for epidermal-dermal intercommunication

Wegner J, Loser K, Apsite G, Nischt R, Eckes B, Krieg T, Werner S, Sorokin L Matrix Biol. 2016 May; PMID: 27234307 Abstract Laminin...   Read More

Tissue fibrosis: a pathomechanistically unresolved challenge and scary clinical problem

Eckes B, Eming SA Exp. Dermatol. 2016 Aug; PMID: 27513440 Abstract Fibrosis is defined as the replacement of healthy tissue by an excessive deposition...   Read More

Proplatelet formation is selectively inhibited by collagen type I via Syk-independent GPVI signaling

Semeniak D, Kulawig R, Stegner D, Meyer I, Schwiebert S, Bösing H, Eckes B, Nieswandt B, Schulze H J. Cell. Sci. 2016 Aug; PMID:...   Read More

Deletion of the epidermis derived laminin γ1 chain leads to defects in the regulation of late hair morphogenesis

Fleger-Weckmann A, Üstün Y, Kloepper J, Paus R, Bloch W, Chen ZL, Wegner J, Sorokin L, Langbein L, Eckes B, Zigrino P, Krieg T,...   Read More

Fibroblast-derived MMP-14 regulates collagen homeostasis in adult skin

Zigrino P, Brinckmann J, Niehoff A, Lu Y, Giebeler N, Eckes B, Kadler KE, Mauch C J. Invest. Dermatol. 2016 Apr; PMID: 27066886 Abstract...   Read More

COMP-assisted collagen secretion – a novel intracellular function required for fibrosis

Schulz JN, Nüchel J, Niehoff A, Bloch W, Schönborn K, Hayashi S, Kamper M, Brinckmann J, Plomann M, Paulsson M, Krieg T, Zaucke F,...   Read More

Interleukin-4 Receptor α Signaling in Myeloid Cells Controls Collagen Fibril Assembly in Skin Repair

B2 WAGENER/ PAULSSONB3 ECKES KRIEGB7 EMINGpublicationsKnipper JA, Willenborg S, Brinckmann J, Bloch W, Maaß T, Wagener R, Krieg T, Sutherland T, Munitz A, Rothenberg ME, Niehoff A, Richardson R, Hammerschmidt M, Allen JE, Eming SA; Immunity. 2015 Oct 20;43(4):803-16. doi: 10.1016/j.immuni.2015.09.005.

Abstract Activation of the immune response during injury is a critical early event that determines whether the outcome of tissue restoration is regeneration or...   Read More

Reduced granulation tissue and wound strength in the absence of α11β1 integrin

B3 ECKES KRIEGpublicationsSchulz JN, Zeltz C, Sørensen IW, Barczyk M, Carracedo S, Hallinger R, Niehoff A, Eckes B, Gullberg D; J Invest Dermatol. 2015 May;135(5):1435-44. doi: 10.1038/jid.2015.24. Epub 2015 Jan 29.

Abstract Previous wound healing studies have failed to define a role for either α1β1 or α2β1 integrin in fibroblast-mediated wound contraction, suggesting the involvement...   Read More

Cyclic mechanical strain induces TGFβ1-signalling in dermal fibroblasts embedded in a 3D collagen lattice

B3 ECKES KRIEGpublicationsPeters AS, Brunner G, Krieg T, Eckes B; Arch Dermatol Res. 2015 Mar;307(2):191-7. doi: 10.1007/s00403-014-1514-2. Epub 2014 Oct 28.

Abstract Many tissues are constantly exposed to mechanical stress, e.g. shear stress in vascular endothelium, compression forces in cartilage or tensile strain in the...   Read More

  • Upcoming Events

    1. SFB Minisymposium – New Technologies for Dermatology

      August 29 @ 1:00 pm - 6:00 pm
    2. 4th German-French DNA Repair Meeting Cologne 2017

      September 21 - September 23
    3. Klenk Symposium 2017 – Tissue regeneration, wound healing and fibrosis: Translating basic concepts into regenerative therapy

      Oktober 15 - Oktober 17

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