Interleukin-4 Receptor α Signaling in Myeloid Cells Controls Collagen Fibril Assembly in Skin Repair

B2 WAGENER/ PAULSSONB3 ECKES KRIEGB7 EMINGpublicationsKnipper JA, Willenborg S, Brinckmann J, Bloch W, Maaß T, Wagener R, Krieg T, Sutherland T, Munitz A, Rothenberg ME, Niehoff A, Richardson R, Hammerschmidt M, Allen JE, Eming SA; Immunity. 2015 Oct 20;43(4):803-16. doi: 10.1016/j.immuni.2015.09.005.

Abstract Activation of the immune response during injury is a critical early event that determines whether the outcome of tissue restoration is regeneration or...   Read More

Reduced granulation tissue and wound strength in the absence of α11β1 integrin

B3 ECKES KRIEGpublicationsSchulz JN, Zeltz C, Sørensen IW, Barczyk M, Carracedo S, Hallinger R, Niehoff A, Eckes B, Gullberg D; J Invest Dermatol. 2015 May;135(5):1435-44. doi: 10.1038/jid.2015.24. Epub 2015 Jan 29.

Abstract Previous wound healing studies have failed to define a role for either α1β1 or α2β1 integrin in fibroblast-mediated wound contraction, suggesting the involvement...   Read More

Cyclic mechanical strain induces TGFβ1-signalling in dermal fibroblasts embedded in a 3D collagen lattice

B3 ECKES KRIEGpublicationsPeters AS, Brunner G, Krieg T, Eckes B; Arch Dermatol Res. 2015 Mar;307(2):191-7. doi: 10.1007/s00403-014-1514-2. Epub 2014 Oct 28.

Abstract Many tissues are constantly exposed to mechanical stress, e.g. shear stress in vascular endothelium, compression forces in cartilage or tensile strain in the...   Read More

Molecular and cellular basis of scleroderma

Eckes B, Moinzadeh P, Sengle G, Hunzelmann N, Krieg T J. Mol. Med. 2014 Sep;92(9):913-24 PMID: 25030650 Abstract Systemic sclerosis (scleroderma) is a chronic...   Read More

Role of integrin signalling through integrin-linked kinase in skin physiology and pathology

Eckes B, Krieg T, Wickström SA Exp. Dermatol. 2014 Jul;23(7):453-6 PMID: 24773528 Abstract Cell-matrix adhesions provide structural stability to the tissue and regulate intracellular...   Read More

Collagen receptors integrin alpha2beta1 and discoidin domain receptor 1 regulate maturation of the glomerular basement membrane and loss of integrin alpha2beta1 delays kidney fibrosis in COL4A3 knockout mice

Rubel D, Frese J, Martin M, Leibnitz A, Girgert R, Miosge N, Eckes B, Müller GA, Gross O Matrix Biol. 2014 Feb;34:13-21 PMID: 24480069...   Read More

Collagen receptors integrin alpha2beta1 and discoidin domain receptor 1 regulate maturation of the glomerular basement membrane…

B3 ECKES KRIEGpublicationsRubel D, Frese J, Martin M, Leibnitz A, Girgert R, Miosge N, Eckes B, Müller GA, Gross O; Matrix Biol. 2014 Feb;34:13-21. doi: 10.1016/j.matbio.2014.01.006. Epub 2014 Jan 27.

Abstract Maturation of the glomerular basement membrane (GBM) is essential for maintaining the integrity of the renal filtration barrier. Impaired maturation causes proteinuria and...   Read More

Age-related bone deterioration is diminished by disrupted collagen sensing in integrin α2β1 deficient mice

B3 ECKES KRIEGpublicationsStange R, Kronenberg D, Timmen M, Everding J, Hidding H, Eckes B, Hansen U, Holtkamp M, Karst U, Pap T, Raschke MJ; Bone. 2013 Sep;56(1):48-54. doi: 10.1016/j.bone.2013.05.003. Epub 2013 May 13.

Abstract Collagen binding integrins are of essential importance in the crosstalk between cells and the extracellular matrix. Integrin α2β1 is a major receptor for...   Read More

CD49b-dependent establishment of T helper cell memory

B3 ECKES KRIEGpublicationsHanazawa A, Hayashizaki K, Shinoda K, Yagita H, Okumura K, Löhning M, Hara T, Tani-ichi S, Ikuta K, Eckes B, Radbruch A, Tokoyoda K, Nakayama T; Immunol Cell Biol. 2013 Sep;91(8):524-31. doi: 10.1038/icb.2013.36. Epub 2013 Jul 30.

Abstract CD4 T cells play a key role in immunological memory. We have demonstrated that professional memory CD4 T cells reside and rest in...   Read More

Systemic sclerosis with multiple nodules: characterization of the extracellular matrix

B3 ECKES KRIEGpublicationsMoinzadeh P, Agarwal P, Bloch W, Orteu C, Hunzelmann N, Eckes B, Krieg T; Arch Dermatol Res. 2013 Sep;305(7):645-52. doi: 10.1007/s00403-013-1383-0. Epub 2013 Jul 9.

Abstract Systemic sclerosis (SSc) is still an enigmatic disease of unknown etiology, although the pathophysiology is thought to be based on vascular alterations as...   Read More

  • Upcoming Events

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