Inhibition of integrin α2β1 ameliorates glomerular injury

B3 ECKES KRIEGpublicationsBorza, C.M., Su, Y., Chen, X., Yu, L., Mont, S., Chetyrkin, S., Voziyan, P., Hudson, B.G., Billings, P.C., Jo, H., Bennett, J.S., DeGrado, W.F., Eckes, B., Zent, R., and Pozzi, A., J Am Soc Nephrol. 2012 Jun;23(6):1027-38. doi: 10.1681/ASN.2011040367. Epub 2012 Mar 22.

Abstract Mesangial cells and podocytes express integrins α1β1 and α2β1, which are the two major collagen receptors that regulate multiple cellular functions, including extracellular...   Read More

Gray platelet syndrome and defective thrombo-inflammation in Nbeal2-deficient mice

B3 ECKES KRIEGpublicationsDeppermann C, Cherpokova D, Nurden P, Schulz JN, Thielmann I, Kraft P, Vögtle T, Kleinschnitz C, Dütting S, Krohne G, Eming SA, Nurden AT, Eckes B, Stoll G, Stegner D, Nieswandt B; J Clin Invest. 2013 Jul 1. pii: 69210. doi: 10.1172/JCI69210. [Epub ahead of print]

Abstract Platelets are anuclear organelle-rich cell fragments derived from bone marrow megakaryocytes (MKs) that safeguard vascular integrity. The major platelet organelles, ?-granules, release proteins...   Read More

Stabilization of integrin-linked kinase by the Hsp90-CHIP axis impacts cellular force generation, migration and the fibrotic response

A11 WICKSTRÖMB3 ECKES KRIEGpublications Radovanac K, Morgner J, Schulz JN, Blumbach K, Patterson C, Geiger T, Mann M, Krieg T, Eckes B, Fässler R, Wickström SA; EMBO J. 2013 May 15;32(10):1409-24. doi: 10.1038/emboj.2013.90. Epub 2013 Apr 23.

Abstract   Integrin-linked kinase (ILK) is an adaptor protein required to establish and maintain the connection between integrins and the actin cytoskeleton. This linkage...   Read More

Dwarfism in mice lacking collagen-binding integrins α2β1 and α11β1 is caused by severely diminished IGF-1 levels

A5 BRÜNING/NIESSENB3 ECKES KRIEGpublicationsBlumbach, K., Niehoff, A., Belgardt, B.F., Ehlen, H.W., Schmitz, M., Hallinger, R., Schulz, J.N., Brüning, J.C., Krieg, T., Schubert, M., Gullberg, D., and Eckes, B., J Biol Chem. 2012 Feb 24;287(9):6431-40. doi: 10.1074/jbc.M111.283119. Epub 2011 Dec 30.

Abstract Mice with a combined deficiency in the α2β1 and α11β1 integrins lack the major receptors for collagen I. These mutants are born with...   Read More

The loss of α2β1 integrin suppresses joint inflammation and cartilage destruction in mouse models of rheumatoid arthritis

B3 ECKES KRIEGpublications Peters MA, Wendholt D, Strietholt S, Frank S, Pundt N, Korb A, Joosten LAB, van den Berg WB, Kollias G, Eckes B, Pap T. , Arthritis Rheum 2011; accepted 16 September

Abstract OBJECTIVE: Integrin α2β1 functions as a major receptor for type I collagen on different cell types, including fibroblasts and inflammatory cells. Although in...   Read More

The mitochondrial electron transport chain is dispensable for proliferation and differentiation of epidermal progenitor cells

Baris OR, Klose A, Kloepper JE, Weiland D, Neuhaus JF, Schauen M, Wille A, Müller A, Merkwirth C, Langer T, Larsson NG, Krieg T,...   Read More

Collagen XXIII, novel ligand for integrin alpha2beta1 in the epidermis

B3 ECKES KRIEGpublications Veit G, Eckes B, Käpylä J, Zweers MC, Niland S, Ishada-Yamamoto A, Krieg T, Heino J, Eble JA, Koch M. J Biol Chem, August 5, 2011 The Journal of Biological Chemistry, 286, 27804-27813.

Abstract Cellular receptors for collagens belong to the family of β(1) integrins. In the epidermis, integrin α(2)β(1) is the only collagen-binding integrin present. Its...   Read More

Integrin α2-deficient mice provide insights into specific functions of collagen receptors in the kidney

B3 ECKES KRIEGpublications Girgert R, Martin M, Kruegel J, Miosge N, Temme J, Eckes B, Muller GA, Gross O., Fibrogenesis & Tissue Repair 2010, 3:19.

Background Integrins are important cellular receptors for collagens. Within the glomerulus, podocytes regulate the integrity of the glomerular basement membrane (GBM) by sensing the...   Read More

The fibroblast integrin alpha11beta1 is induced in a mechanosensitive manner involving activin A and regulates myofibroblast differentiation

B3 ECKES KRIEGpublications Carracedo S, Lu N, Popova SN, Jonsson R, Eckes B, Gullberg D. J Biol Chem 285, 10434-10445, 2010  

Abstract Fibrotic tissue is characterized by an overabundance of myofibroblasts. Thus, understanding the factors that induce myofibroblast differentiation is paramount to preventing fibrotic healing....   Read More

Expression of integrin ß1 by fibroblasts is required for tissue repair in vivo

B3 ECKES KRIEGpublications Liu S, Shi-wen X, Blumbach K, Eastwood M, Denton CP, Eckes B, Krieg T, Abraham DJ, Leask A. J Cell Sci 123, 3674-3682, 2010

Abstract In tissue repair, fibroblasts migrate into the wound to produce and remodel extracellular matrix (ECM). Integrins are believed to be crucial for tissue...   Read More

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