Dwarfism in mice lacking collagen-binding integrins α2β1 and α11β1 is caused by severely diminished IGF-1 levels

A5 BRÜNING/NIESSENB3 ECKES KRIEGpublicationsBlumbach, K., Niehoff, A., Belgardt, B.F., Ehlen, H.W., Schmitz, M., Hallinger, R., Schulz, J.N., Brüning, J.C., Krieg, T., Schubert, M., Gullberg, D., and Eckes, B., J Biol Chem. 2012 Feb 24;287(9):6431-40. doi: 10.1074/jbc.M111.283119. Epub 2011 Dec 30.

Abstract Mice with a combined deficiency in the α2β1 and α11β1 integrins lack the major receptors for collagen I. These mutants are born with...   Read More

The loss of α2β1 integrin suppresses joint inflammation and cartilage destruction in mouse models of rheumatoid arthritis

B3 ECKES KRIEGpublications Peters MA, Wendholt D, Strietholt S, Frank S, Pundt N, Korb A, Joosten LAB, van den Berg WB, Kollias G, Eckes B, Pap T. , Arthritis Rheum 2011; accepted 16 September

Abstract OBJECTIVE: Integrin α2β1 functions as a major receptor for type I collagen on different cell types, including fibroblasts and inflammatory cells. Although in...   Read More

The mitochondrial electron transport chain is dispensable for proliferation and differentiation of epidermal progenitor cells

Baris OR, Klose A, Kloepper JE, Weiland D, Neuhaus JF, Schauen M, Wille A, Müller A, Merkwirth C, Langer T, Larsson NG, Krieg T,...   Read More

Collagen XXIII, novel ligand for integrin alpha2beta1 in the epidermis

B3 ECKES KRIEGpublications Veit G, Eckes B, Käpylä J, Zweers MC, Niland S, Ishada-Yamamoto A, Krieg T, Heino J, Eble JA, Koch M. J Biol Chem, August 5, 2011 The Journal of Biological Chemistry, 286, 27804-27813.

Abstract Cellular receptors for collagens belong to the family of β(1) integrins. In the epidermis, integrin α(2)β(1) is the only collagen-binding integrin present. Its...   Read More

Integrin α2-deficient mice provide insights into specific functions of collagen receptors in the kidney

B3 ECKES KRIEGpublications Girgert R, Martin M, Kruegel J, Miosge N, Temme J, Eckes B, Muller GA, Gross O., Fibrogenesis & Tissue Repair 2010, 3:19.

Background Integrins are important cellular receptors for collagens. Within the glomerulus, podocytes regulate the integrity of the glomerular basement membrane (GBM) by sensing the...   Read More

The fibroblast integrin alpha11beta1 is induced in a mechanosensitive manner involving activin A and regulates myofibroblast differentiation

B3 ECKES KRIEGpublications Carracedo S, Lu N, Popova SN, Jonsson R, Eckes B, Gullberg D. J Biol Chem 285, 10434-10445, 2010  

Abstract Fibrotic tissue is characterized by an overabundance of myofibroblasts. Thus, understanding the factors that induce myofibroblast differentiation is paramount to preventing fibrotic healing....   Read More

Expression of integrin ß1 by fibroblasts is required for tissue repair in vivo

B3 ECKES KRIEGpublications Liu S, Shi-wen X, Blumbach K, Eastwood M, Denton CP, Eckes B, Krieg T, Abraham DJ, Leask A. J Cell Sci 123, 3674-3682, 2010

Abstract In tissue repair, fibroblasts migrate into the wound to produce and remodel extracellular matrix (ECM). Integrins are believed to be crucial for tissue...   Read More

Defective granulation tissue formation in mice with specific ablation of integrin-linked kinase in fibroblasts – role of TGFß1 levels and RhoA activity

B3 ECKES KRIEGpublications Blumbach K, Zweers MC, Brunner G, Peters AS, Schmitz M, Schulz JN, Schild A, Denton CP, Sakai T, Faessler R, Krieg T, Eckes B. J Cell Sci 123, 872-3883, 2010  

Abstract Wound healing crucially relies on the mechanical activity of fibroblasts responding to TGFβ1 and to forces transmitted across focal adhesions. Integrin-linked kinase (ILK)...   Read More

Role of tyrosine phosphatase SHP-1 in the mechanism of endorepellin angiostatic activity

B3 ECKES KRIEGpublications Nyström A, Shaik ZP, Gullberg D, Krieg T, Eckes B, Zent R, Pozzi A, Iozzo RV. Blood 114, 4897-906, 2009

Abstract Endorepellin, the C-terminal domain of perlecan, is a powerful angiogenesis inhibitor. To dissect the mechanism of endorepellin-mediated endothelial silencing, we used an antibody...   Read More

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